Tumors and tumor-like proliferations of fibrous and related tissues

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00035-8

Cited by 20 publications

(47 citation statements)

References 1,129 publications

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“…1,2,5,6,7 Lesions are symmetrical, round 1,2 , and nonencapsulated. 1,2,4,6 A typical characteristic of this type of lesion is the absence of clear demarcations, 1,2,4,6 both in their lateral margins and depth. 1,5 In most FH cases there is a zone of relatively normal collagen of variable thickness demarcating the boundary between normal epidermis and a dermal lesion (Grenz zone).…”

Section: Introductionmentioning

confidence: 99%

“…Several variants have been described and more than one may be present in the same lesion. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Cytologically, most cells are fusiform and oval, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] with vesiculous nuclei, slightly prominent nucleoli, and scant amphophilic cytoplasm. 1,2 There are small grouped or isolated cells of xanthomatous cytoplasm or cytoplasm filled with hemosiderin in between fusiform cells.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7] The presence of an inflammatory infiltrate typically lymphocitary, of variable intensity, is common. 1,2,4,6 Another typical histopathological finding consists in the encapsulation of collagen bundles, making it hyaline or keloid-like in the periphery of the tumor. 1,2,5,6,7 Lesions are symmetrical, round 1,2 , and nonencapsulated.…”

Section: Introductionmentioning

confidence: 99%

“…1,5 In most FH cases there is a zone of relatively normal collagen of variable thickness demarcating the boundary between normal epidermis and a dermal lesion (Grenz zone). 1,4,6 Tumors are located in the medium dermis and sometimes they extend to the hypodermis. 1,2,[4][5][6][7] This extension is observed throughout the fibrous septa, separating fat lobules 1,2,4,5,7 .…”

Section: Introductionmentioning

confidence: 99%

“…1,4,6 Tumors are located in the medium dermis and sometimes they extend to the hypodermis. 1,2,[4][5][6][7] This extension is observed throughout the fibrous septa, separating fat lobules 1,2,4,5,7 . Peripheral infiltration of fat lobules, in a pattern similar to that of dermatofibrosarcoma protuberans (DFSP), rarely occurs.…”

Section: Introductionmentioning

confidence: 99%

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Histiocitomas fibrosos: revisão histopatológica de 95 casos

Canelas

Cardoso

Andrade

et al. 2010

An. Bras. Dermatol.

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Fibrous histiocytoma (FH) is a heterogeneous tumor composed of fibroblasts, histiocytes, and blood vessels. We conducted a retrospective histopathologic analysis of 95 biopsies, performed over the last 3.5 years, of fibrous histiocytomas to analyze the location, delimitation, epithelial changes, induction of folliculo-sebaceous structures, cellularity, vascularity, collagen pattern, and types of composite cells of the FH. In the majority of the biopsies, we confirmed the classical histopathologic features of fibrous histiocytomas. The presence of lymphoid nodules, mast cells, and sparse infiltrate of inflammatory cells was an interesting finding observed in our study. Keywords: Histiocytes; Histiocytoma benign fibrous; Histology Resumo: O histiocitoma fibroso é tumor heterogéneo composto por fibroblastos, histiócitos e vasos sanguíneos. Efectuamos uma revisão histopatológica retrospectiva de 95 biopsias de histiocitomas fibrosos do nosso arquivo dos últimos 3,5 anos, com o objectivo de avaliar a localização, delimitação, alteração da epiderme, indução folículo-sebácea, celularidade, vascularização, padrão do colagénio e tipo de células constituintes. Na maioria das biopsias, confirmamos as características histopatológicas clássicas dos histiocitomas fibrosos. Achados interessantes observados no nosso estudo foram presença de células nódulos linfoides, mastócitos e infiltrado de células inflamatórias.

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Section: Introductionmentioning

confidence: 99%