2006
DOI: 10.1172/jci28828
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Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

Abstract: Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b+IL-4 receptor alpha+ (CD11b+IL-4Ralpha+), inflammatory-type monocytes that is elicited by growing tumors and … Show more

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Cited by 735 publications
(759 citation statements)
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“…the gut macrophage) and the immunological microenvironment. Two papers published in this issue of the European Journal of Immunology [5,6], as well as other recently published reports [7][8][9][10][11], add new elements and perspectives to the current understanding of mononuclear phagocyte differentiation and activation.Multinucleated giant cells (MGC) are a prominent, characteristic feature of granulomas, which are caused by different agents but are exemplified by mycobacterial infections. MGC derive from the fusion of macrophages and, although different molecules have been implicated in the formation of MGC including TREM2, CD44 and more recently the P 2 X 7 nucleotide receptor [12], the molecular basis of their formation and their actual significance in chronic inflammation remains elusive.…”
mentioning
confidence: 93%
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“…the gut macrophage) and the immunological microenvironment. Two papers published in this issue of the European Journal of Immunology [5,6], as well as other recently published reports [7][8][9][10][11], add new elements and perspectives to the current understanding of mononuclear phagocyte differentiation and activation.Multinucleated giant cells (MGC) are a prominent, characteristic feature of granulomas, which are caused by different agents but are exemplified by mycobacterial infections. MGC derive from the fusion of macrophages and, although different molecules have been implicated in the formation of MGC including TREM2, CD44 and more recently the P 2 X 7 nucleotide receptor [12], the molecular basis of their formation and their actual significance in chronic inflammation remains elusive.…”
mentioning
confidence: 93%
“…the gut macrophage) and the immunological microenvironment. Two papers published in this issue of the European Journal of Immunology [5,6], as well as other recently published reports [7][8][9][10][11], add new elements and perspectives to the current understanding of mononuclear phagocyte differentiation and activation.…”
mentioning
confidence: 93%
See 3 more Smart Citations