Tumors induced in hamsters by a strain of adenovirus type 3: sharing of tumor antigens and "neoantigens" with those produced by adenovirus type 7 tumors.

Huebner, Robert J.; Casey, M. J.; Chanock, R. M.; Schell, Klaus

doi:10.1073/pnas.54.2.381

Cited by 77 publications

(27 citation statements)

References 40 publications

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“…These results are similar to those observed for adenovirus type 7 (Huebner et al 1965). Since only one hamster produced multiple turnouts (two in the dorsal area), it is likely that hamsters may develop antibodies inhibiting the initiation of a second tumour once the first has become established.…”

Section: Discussionsupporting

confidence: 77%

“…Several human adenoviruses are oncogenic; these include types 3, 7, I2, 18 and 3r (Huebner et al 1965;Huebner, Rowe & Lane, I962;Larson et al I965;Pereira, Pereira & Clarke, 1965;Trentin, Yabe & Taylor, 1962). In I965 it was reported by Sarma, Huebner & Lane that the chick embryo lethal orphan (CELO) virus, an avian adenovirus, was also oncogenic for hamsters.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tumour Formation in Hamsters Inoculated with Chick Embryo Lethal Orphan Virus

Mancini

Yates

Anderson

et al. 1971

Journal of General Virology

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Tumour Formation in Hamsters Inoculated with Chick Embryo Lethal Orphan Virus

Mancini

Yates

Anderson

et al. 1971

Journal of General Virology

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“…One of our concerns over the use of Ad11 as a gene transfer vector was the mild oncogenicity of wild-type B group Ads previously seen in rodents (15,16,22,30). Although no link between human cancer and Ad7 or Ad11 DNA was found in a previous study with radiolabeled Ad7 and Ad11 DNA and normal and tumor DNA from multiple organs (71), we wanted to compare the transforming activity of Ad11 with Ad5, which VOL.…”

Section: Discussionmentioning

confidence: 99%

“…SV40 P , SV40 promoter, MCS, multiple cloning site; EM, electron micrograph; RGD, arginine, glycine, and aspartic acid. (15,16,22,30), while Ad serotype 5 is not oncogenic in rodents (7). In order to assess the transforming potential of Ad11 in the context of an Ad vector backbone, cellular transformation assays were carried out in BRK cells with recombinant Ad5 and Ad11 vector genome plasmids with or without E1 sequences.…”

Section: Stability Of Ad11 Vectorsmentioning

confidence: 99%

Development and Assessment of Human Adenovirus Type 11 as a Gene Transfer Vector

Stone

et al. 2005

J Virol

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“…type 7 (16). The adeno 7 neoantigen on the other hand cross-reacts with the corresponding antigens induced by types 3, 4, 11, 14, 16, and 21.…”

mentioning

confidence: 99%

Specific Transplantation Antigens of Mouse Sarcomas Induced by Adenovirus Type 12

Sjögren

Minowada

Ankerst

1967

The Journal of Experimental Medicine

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All viral tumors investigated have been found to contain specific antigens common for all the neoplasms induced by the same virus but usually different for tumors induced by different viruses (1, 2). This pattern was demonstrated first for transplantation antigens, and has subsequently been demonstrated for the so called neoantigens detected by the complement fixation (CF) technique (3-5). These latter antigens are probably identical with those detected by fluorescent antibody (FA) tests on fixed cell preparations (6). The specific surface antigens detected by the FA technique in living leukemia cells are probably identical with the transplantation antigens of these cells (7).The human adenovirus type 12 induces tumors in hamsters, rats, and mice (8, 9). The hamster neoplasms have been extensively studied for their content of virion antigens and neoantigens. Infectious virus has never been recovered from tumors induced by adeno 12 virus (8, 10, 11), although indirect indications have been obtained for the presence of the type-specific C virion antigen in hamster tumors (12, 13), by use of the CF and immunodiffusion techniques. Sera of hamsters carrying primary tumors were found to contain antibodies against the C antigen although this antigen was never detected when tumor cell preparations were tested directly. Indications for the existence of another virion antigen (called antigen D) in hamster tumor cells has been obtained by immunodiffusion tests (13).Extracts of hamster adeno 12 tumors have been found to contain a common specific antigen (the so called neoantigen) detectable by the CF and immunodiffusion techniques (10,13). This antigen appears to be identical with an antigen synthesized early during the in vitro infection cycle of human cells (14). In addition the neoantigen as detected by FA technique has been reported to appear in other mammalian cells (monkey, hamster, mouse, rabbit, rat, and chick) infected in vitro (15). In CF tests the adeno 12 neoantigen cross-reacts with a similar antigen present in neoplasms induced by adenovirus types 18 and 31 and with the antigens produced in human cells infected by these viruses. It

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Tumors induced in hamsters by a strain of adenovirus type 3: sharing of tumor antigens and "neoantigens" with those produced by adenovirus type 7 tumors.

Cited by 77 publications

References 40 publications

Tumour Formation in Hamsters Inoculated with Chick Embryo Lethal Orphan Virus

Tumour Formation in Hamsters Inoculated with Chick Embryo Lethal Orphan Virus

Development and Assessment of Human Adenovirus Type 11 as a Gene Transfer Vector

Specific Transplantation Antigens of Mouse Sarcomas Induced by Adenovirus Type 12

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