Tumors Involving Skin, Soft Tissue and Skeletal Muscle: Benign, Primary Malignant or Metastatic?

Hsieh, Chi-Ying; Tsai, Huang-Wen; Chang, Chih‐Chun; Lin, Tsuo-Wu; Chang, Kai‐Chih; Chen, Yo-Shen

doi:10.7314/apjcp.2015.16.15.6681

Cited by 5 publications

(3 citation statements)

References 19 publications

(18 reference statements)

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“…11 In present study, the malignant lesions predominantly seen in skin and soft tissues was basal cell carcinoma followed by cutaneous squamous cell carcinoma. This was in accord with observation of Hsieh CY et al 16 Oral cavity lesions constituted 20.69% of present study and were found to be more common in males. The most common site of involvement was buccal mucosa followed by lip and tongue.…”

Section: Discussionsupporting

confidence: 82%

Histopathological patterns of head and neck lesions - a two year retrospective hospital based study

Sharma¹,

Sharma²,

Gandhi³

et al. 2017

Int J Res Med Sci

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Background: Head and neck lesions include a spectrum of pathological lesions ranging from simple benign to highly malignant entities. These lesions contribute significantly to morbidity and mortality of patients. The aim of this study was to determine the histological patterns of head and neck lesions, both non- neoplastic and neoplastic and to analyse the data in relation to age, gender, topography.Methods: A two year retrospective study was conducted in the Post Graduate Department of Pathology, ASCOMS and Hospital and histopathological data pertaining to all head and neck lesions was reviewed. Each case was analysed with respect to age, gender, site and histological type.Results: One hundred and forty-five cases from the head and neck region were analysed during this two-year period. Age range was from 3 months to 85 years with maximum cases in the age group of 21-50 years (51.03%). The Male: Female ratio was 1.37:1. In our study, 53.79% benign, 24.13% inflammatory and 22.06% malignant cases were recorded. Maximum number of benign lesions was in the age group of 21-50 years. Malignancies were noted to be higher in ages 51 years and above. Squamous cell carcinoma was the most common malignancy observed.Conclusions: We conclude that site specific data like this is helpful in evaluating patterns of head and neck lesions and augment the base line data of institute and the region.

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Section: Discussionsupporting

confidence: 82%

Histopathological patterns of head and neck lesions - a two year retrospective hospital based study

Sharma¹,

Sharma²,

Gandhi³

et al. 2017

Int J Res Med Sci

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show abstract

“…Hsieh et al also performed an analysis of soft tissue masses, showing significantly lower malignancy rates. In contrast to our study, lesions of all sizes and especially tumors of the skin were included [14]. Overall, the results of our study show that, despite relatively low rates of malignancy, even smaller lesions should be considered as potentially malignant [6,11].…”

Section: Discussionmentioning

confidence: 60%

Soft tissue masses: distribution of entities and rate of malignancy in small lesions

Gassert

Specht

et al. 2021

BMC Cancer

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Background Small soft tissue masses are often falsely assumed to be benign and resected with failure to achieve tumor-free margins. Therefore, this study retrospectively investigated the distribution of histopathologic diagnosis to be encountered in small soft tissue tumors (≤ 5 cm) in a large series of a tertiary referral center. Methods Patients with a soft tissue mass (STM) with a maximum diameter of 5 cm presenting at our institution over a period of 10 years, who had undergone preoperative Magnetic resonance imaging and consequent biopsy or/and surgical resection, were included in this study. A final histopathological diagnosis was available in all cases. The maximum tumor diameter was determined on MR images by one radiologist. Moreover, tumor localization (head/neck, trunk, upper extremity, lower extremity, hand, foot) and depth (superficial / deep to fascia) were assessed. Results In total, histopathologic results and MR images of 1753 patients were reviewed. Eight hundred seventy patients (49.63%) showed a STM ≤ 5 cm and were therefore included in this study (46.79 +/− 18.08 years, 464 women). Mean maximum diameter of the assessed STMs was 2.88 cm. Of 870 analyzed lesions ≤ 5 cm, 170 (19.54%) were classified as superficial and 700 (80.46%) as deep. The malignancy rate of all lesions ≤ 5 cm was at 22.41% (superficial: 23.53% / deep: 22.14%). The malignancy rate dropped to 16.49% (20.79% / 15.32%) when assessing lesions ≤ 3 cm (p = 0.007) and to 15.0% (18.18% / 13.79%) when assessing lesions ≤ 2 cm (p = 0.006). Overall, lipoma was the most common benign lesion of superficial STMs (29.41%) and tenosynovial giant cell tumor was the most common benign lesion of deep STMs (23.29%). Undifferentiated pleomorphic sarcoma was the most common malignant diagnosis among both, superficial (5.29%) and deep (3.57%) STMs. Conclusions The rate of malignancy decreased significantly with tumor size in both, superficial and deep STMs. The distribution of entities was different between superficial and deep STMs, yet there was no significant difference found in the malignancy rate.

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“…Despite the fact that soft tissue comprises about half of our total body mass, distant metastases to these areas are rare and account for about only 0.36% of all soft-tissue tumors [ 8 ]. Most cases found in the literature result from either single reports or small case series.…”

Section: Discussionmentioning

confidence: 99%

Solitary Soft-Tissue Metastasis of a Pancreatic Adenocarcinoma 2 Years After Curative Resection: Report of a Rare Case and a Literature Review

et al. 2022

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Patient: Female, 74-year-old Final Diagnosis: Soft tissue metastasis from pancreatic adenocarcinoma Symptoms: Palpable, hard and painful mass, with rapid growth, located in the posterior aspect of the upper left thigh Medication: — Clinical Procedure: — Specialty: Surgery Objective: Rare disease Background: Soft-tissue metastases from a primary carcinoma are rare lesions. They often are the first clinical manifestation of a previously unknown malignancy of an advanced stage, but may also be solitary in a setting of a recurrent disease. Generally, they are associated with poor prognosis and may be the source of diagnostic confusion both clinically and pathologically. The primary location of the malignancy is usually lung, breast, kidney, or colon. Soft-tissue metastases from a pancreatic adenocarcinoma are extremely rare. A few cases involving the skin have been described in the literature, and solitary metastasis to the deep soft-tissue (eg, subcutis and skeletal muscle) was reported less than 10 times. Case Report: We report the case of a 74-year-old woman who presented with late-onset (recurrent disease), solitary, subcutaneous metastasis in the posterior aspect of the left thigh, deriving from a pancreatic head adenocarcinoma, 2 years after initial treatment with R0 resection (pancreaticoduodenectomy) and adjuvant chemotherapy. We emphasize the rarity of this entity, review the literature, and discuss treatment options. Conclusions: Solitary soft-tissue metastasis from a pancreatic adenocarcinoma after initial curative treatment is very rare. Although hematogenous spread from a pancreatic adenocarcinoma generally has a very poor prognosis, treatment should be individualized according to the patient’s history, general condition, and symptoms and the clinical setting in relation to the primary disease.

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Tumors Involving Skin, Soft Tissue and Skeletal Muscle: Benign, Primary Malignant or Metastatic?

Cited by 5 publications

References 19 publications

Histopathological patterns of head and neck lesions - a two year retrospective hospital based study

Histopathological patterns of head and neck lesions - a two year retrospective hospital based study

Soft tissue masses: distribution of entities and rate of malignancy in small lesions

Solitary Soft-Tissue Metastasis of a Pancreatic Adenocarcinoma 2 Years After Curative Resection: Report of a Rare Case and a Literature Review

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