Tumors of ceruminous glands

Cankar, V.; Crowley, Helena M.

doi:10.1002/1097-0142(196401)17:1<67::aid-cncr2820170109>3.0.co;2-a

Cited by 62 publications

(9 citation statements)

References 8 publications

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“…We are obliged to turn to a review of the literature in order to get a better idea of the nature of these tumours. Most papers on 'ceruminoma' appearing in the literature over the past 30 years have been individual case reports (Smith and Duarte, 1962;Grossman et al, 1964;Arora, 1964;Coyas and Adamopoulos, 1966;Ramadass, 1966;Neldner, 1968;Turner et al, 1971;Koopot et al, 1973;Hageman and Becker, 1974;Michel et al, 1978;Habib, 1981;Nissime/a/., 1981), or a small series of up to seven cases (Cankar and Crowley, 1964;Batsakis et al, 1967;Anagnostou et al, 1974;Ramadass and Satuanarayana, 1973;Lynde et al, 1984). Three major reviews of 'ceruminoma' have appeared in the literature in the past 20 years (Wetli etal., 1972;Pahor and O'Hara, 1975;Dehner and Chen, 1980).…”

Section: Treatment and Prognosismentioning

confidence: 99%

‘Ceruminoma’ – a defunct diagnosis

Douglas-Jones

1995

J. Laryngol. Otol.

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The clinical and pathological features of glandular tumours of the external auditory meatus are presented. Their heterogenous clinical and pathological features make the collective term ‘ceruminoma’ ambiguous andmisleading. The spectrum of pathological behaviour and histological features demonstrated by these interesting tumours necessitate a broader classification system. In our hospital 32 patients presented with tumours of the external auditory meatus over a 30-year period, of which seven were glandular in origin. A review of the histology of these glandular tumours enabled us to reclassify them as adenoma, cylindroma, adenoid cystic carcinoma or ceruminous adenocarcinoma. Together with the less common mucoepidermoid carcinoma and pleomorphic adenoma this subdivision forms a basis for a more meaningful classification system with prognostic and therapeutic implications specific to each tumour type. The term ‘ceruminoma’ should no longer be used unqualified.

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Section: Treatment and Prognosismentioning

confidence: 99%

‘Ceruminoma’ – a defunct diagnosis

Douglas-Jones

1995

J. Laryngol. Otol.

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“…Ceruminous adenocarcinoma, microscopically, characterized by variously sized glandular formations arranged in back to back proliferation and lined by apocrine cells ( 7 ). Presence of more than occasional mitotic activity, pleomorphism, the absence of a myoepithelial layer, necrosis and invasiveness are the main diagnostic features ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

Respiratory Epithelial Adenomatoid Hamartoma: A Very Rare Entity Originating from the External Auditory Canal

2020

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Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon lesion of the upper aerodigestive tract. It is characterized by abnormal glandular formations with ciliated epithelium arising from the nasal cavity, paranasal sinuses and nasopharynx, but other locations have also been described. We did not find any other cases of this hamartomas in the external auditory canal in the literature. A 40-year-old man was referred to the otorhinolaryngology department due to otorrhea and decreased hearing from 1 year ago. Otoscopic examination showed a reddish hemorrhagic mass in the left external auditory canal. Intraoperatively, the tumor was completely resected. The pathologic findings were consistent with REAH.

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“…These granules are periodic acid-Schiff (PAS) positive, Sudan black positive, and also stain with the Ziehl-Neelsen acid-fast method. It is quite interesting to note that while this yellow-brown granule confirms the ceruminous nature of the benign neoplasms (ceruminous adenoma), these granules are not identified in the cytoplasm of the malignant neoplasms [30]. The immediately adjacent, uninvolved ceruminous glands will contain the pigment, helping to confirm the point of origin, and this finding can be helpful when trying to separate benign and malignant neoplasms of the ceruminous glands, especially when the biopsies are small and limited.…”

Section: Discussionmentioning

confidence: 99%

“…The secretions were frequently admixed with cellular debris within the gland lumen. The characteristic golden-yellow-brown pigment (cerumen granules) within the cytoplasm of benign ceruminous glands and benign ceruminous neoplasms, is not identified in malignant tumors [30]. This absence (after careful examination) may help in separating benign from malignant ceruminous tumors.…”

Section: Discussionmentioning

confidence: 99%

Ceruminous Gland Carcinomas: A Clinicopathologic and Immunophenotypic Study of 17 Cases

Crain

Nelson

Barnes

et al. 2008

Head and Neck Pathol

103

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Background Ceruminal gland carcinomas are rare neoplasms confined to the skin lining the cartilaginous part of the external auditory canal. Design Retrospective. Results The patients included 11 men and 6 women, aged 33–82 years (mean, 59.5 years). Patients presented clinically with a mass of the outer half of the external auditory canal (n = 14), hearing changes (n = 5), drainage (n = 4), or paralysis of the facial nerve (n = 3). The polypoid masses ranged in size from 0.5 to 3 cm in greatest dimension (mean, 1.8 cm). Histologically, the tumors demonstrated a solid to cystic pattern, composed of an infiltrating glandular to cribriform arrangement of epithelial cells. Histologic features included a dual cell population (although not the dominant histology), increased cellularity, moderate to severe nuclear pleomorphism, irregular nucleoli, increased mitotic figures (mean, 3/10 HPF), including atypical forms, and tumor necrosis (n = 2). Tumors were divided into three types of adenocarcinoma based on pattern of growth and cell type (ceruminous, NOS [n = 12], adenoid cystic [n = 4], mucoepidermoid [n = 1]). CK7 and CD117 highlighted the luminal cells, while S1-00 protein showed a predilection for the basal cells of ceruminous and adenoid cystic carcinomas. Metastatic adenocarcinoma or direct extension from salivary gland neoplasms are the principle differential considerations. Surgical resection was used in all patients with radiation used in four patients. Eleven patients were alive or had died of unrelated causes without evidence of disease (mean, 11.2 years); six patients had died with disease (mean, 4.9 years), all of whom had developed local recurrence. Conclusion Ceruminous-type carcinomas, with the exception of ceruminous mucoepidermoid carcinoma, all demonstrated a dual cell population of basal myoepithelial-type cells and luminal apocrine cells. The specific histologic sub-type does not influence the long-term patient outcome.

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Tumors of ceruminous glands

Cited by 62 publications

References 8 publications

‘Ceruminoma’ – a defunct diagnosis

‘Ceruminoma’ – a defunct diagnosis

Respiratory Epithelial Adenomatoid Hamartoma: A Very Rare Entity Originating from the External Auditory Canal

Ceruminous Gland Carcinomas: A Clinicopathologic and Immunophenotypic Study of 17 Cases

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