Tumors of muscle, cartilage, and bone

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00037-1

Cited by 5 publications

(7 citation statements)

References 249 publications

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“…The mean age at diagnosis in our solitary piloleiomyoma patients was 56 years, and they were somewhat more frequent in females than in males (30/21). Some authors have stated that piloleiomyomas are more frequently multiple than solitary [7,8,10]. However, in the present study, patients with multiple piloleiomyomas accounted only for 16% of all piloleiomyoma cases.…”

Section: Discussioncontrasting

confidence: 67%

“…Histopathologically, piloleiomyomas are poorly defined, non-encapsulated dermal tumours, composed of smooth muscle fibres intermingled with collagen bundles [7]. An unaffected area of dermis beneath the dermo-epidermal junction (grenz zone) is usually observed, and more than 50% of cases show epidermal hyperplasia [8]. Genital leiomyomas are usually well circumscribed, al- though some cases may be poorly demarcated, and histopathologically indistinguishable from piloleiomyomas [9].…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Leiomyoma: A Clinical Study of 152 Patients

et al. 2021

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Background: Cutaneous leiomyoma (CL) is a benign smooth muscle tumour included in painful skin tumours. Multiple CLs are cutaneous markers of hereditary leiomyomatosis and renal cell cancer (HLRCC). Objectives: To retrospectively review our series of patients with CLs to analyse their clinical features and the association with HLRCC. Methods: Cases coded as CL in the database of the pathology department between 2004 and 2019 were included in the study. Medical records were retrospectively reviewed to obtain the following data: age, sex, location, number of lesions, diameter, evolution time at diagnosis, suspected clinical diagnosis, tenderness, status of resection margins, development of recurrence, follow-up time, and association with HLRCC. Results: 152 patients had CLs, 89 women and 63 men, mean age 56.26, SD 16.030 years. Subtypes were piloleiomyoma in 62 patients, angioleiomyoma in 80, and genital leiomyoma in 10. All of our 11 patients with multiple lesions corresponded to piloleiomyomas, and HLRCC was confirmed in 8 of them (73%). Patients with HLRCC were younger than patients with piloleiomyomas without HLRCC (34.88 vs. 56.17 years, p = 0.009). Vascular and genital leiomyomyomas were solitary and were not associated with HLRCC. Conclusion: In patients with multiple piloleiomyomas HLRCC must be ruled out as it is confirmed in a high proportion of cases. The probability of fumarate hydratase mutation is greater in multiple piloleiomyomas involving both the trunk and upper extremities in the same patient.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Cutaneous Leiomyoma: A Clinical Study of 152 Patients

et al. 2021

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“…The collagen between smooth muscle bundles is not plentiful like it is in smooth muscle hamartoma, as demonstrated in our case. 7,8 Pilar leiomyomas usually appear in the second to the third decades of life. Leiomyomas occurring at birth are extremely rare.…”

Section: Discussionmentioning

confidence: 99%

Congenital pilar leiomyoma

Akay

Boyvat

Heper

et al. 2008

Journal of the American Academy of Dermatology

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“…As PDS is frequently aggressive and related to adverse outcomes [ 2 ], it is critical to recognize its distinguishing features in comparison to similar entities. Differential diagnoses of PDS include atypical fibroxanthoma (AFX) and pleomorphic leiomyosarcoma (PLMS) [ 1 , 2 , 3 , 4 ]. Hereafter, we describe the case of a patient who presented with an extensive tumor on the face that was eventually diagnosed as PDS.…”

Section: Introductionmentioning

confidence: 99%

A Case of Pleomorphic Dermal Sarcoma: Giant Exophytic Tumor of the Medial Canthus

Moody,

Darji,

Missall

et al. 2023

Dermatopathology

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We present the case of a 99-year-old Caucasian female who was referred for treatment of a painless, 8.0 cm × 7.8 cm exophytic, pedunculated, ulcerated tumor of the left medial canthus. Pathology showed spindled, oval, and polygonal cells with pleomorphic nuclei. Many multinuclear giant cells and mitotic figures were also noted. The tumor was highlighted with CD10, showed focal positivity with actin, desmin, and CD68, and had increased Ki67 immunohistochemical staining. The tumor was negative for pancytokeratin, CK5/6, p63, MART-1/MelanA, S100, Sox10, p40, CD34, and CD23. Based on clinicopathologic correlation, the diagnosis of pleomorphic dermal sarcoma (PDS) was made. Pleomorphic dermal sarcoma (PDS) refers to a deep, histologically high-grade tumor that often resembles other tumors clinically and histologically. As PDS is frequently aggressive and related to adverse outcomes, it is important to recognize its distinguishing features in comparison to other similar entities, including atypical fibroxanthoma (AFX) and pleomorphic leiomyosarcoma (PLMS). To our knowledge, there is only one other reported case in the literature of PDS occurring on the eye. By reviewing and understanding characteristic etiologies, locations of presentation, histopathological features, and management techniques, pathologists can make a more accurate diagnosis and dermatologists can provide more effective patient care in a timely manner.

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Tumors of muscle, cartilage, and bone

Cited by 5 publications

References 249 publications

Cutaneous Leiomyoma: A Clinical Study of 152 Patients

Cutaneous Leiomyoma: A Clinical Study of 152 Patients

Congenital pilar leiomyoma

A Case of Pleomorphic Dermal Sarcoma: Giant Exophytic Tumor of the Medial Canthus

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