Tumors of the Brain in Aged Persons

Moersch, Frederick P.

doi:10.1001/archneurpsyc.1941.02280140045004

Cited by 34 publications

(7 citation statements)

References 5 publications

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“…Eighty per cent of their patients had glioblastoma multiforme at necropsy. Moersch et al (1941), noted that onethird of their patients with necropsy proved glioblastoma were diagnosed clinically as strokes. McLaurin and Helmer (1962) reported 22 cases of brain tumours misdiagnosed during life, including two primary brain-stem gliomas clinically diagnosed as basilar artery occlusions.…”

Section: Discussionmentioning

confidence: 99%

Pure motor hemiplegia secondary to brain-stem tumour.

Levitt¹,

Selkoe²,

Frankenfield³

et al. 1975

Journal of Neurology, Neurosurgery & Psychiatry

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Complete blood count, urinalysis, and electrolytes were normal except for 10,800 leucocytes/mm3.Lumbar puncture showed opening pressure of 300 mm water, closing pressure of 180 mm with 1,952 leucocytes/mm3 (58% polymorphonuclear cells, 42% mononuclear cells), protein 0.74 g/l, and glucose 4.11 mmol/l. Gram stain and India ink preparations were negative; bacterial, fungal, and tuberculosis cultures showed no growth. EEG, skull radiograph, and brain isotope scan were normal.The patient was treated with intravenous ampicillin, and what had been assumed to be a meningitis cleared. Repeat lumbar puncture one week later showed only 9 lymphocytes/mm3; protein and sugar were normal. She was discharged and remained stable for the next two months, when she had a sudden onset of diplopia and was found to have a left sixth nerve palsy. Over the next two months she developed progressive ataxia of gait, dysarthria, and further weakness of her left limbs. Vertical nystagmus appeared and a diminished gag reflex and dysphagia. A four-vessel cerebral angiogram was performed and was normal. She continued to deteriorate and died six months after her initial admission.NECROPSY Findings at necropsy included a large pulmonary embolus which was considered to be the immediate cause of death. The basis pontis, surrounding structures, and meninges were replaced and infiltrated by a diffuse, focally necrotic mass

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Section: Discussionmentioning

confidence: 99%

Pure motor hemiplegia secondary to brain-stem tumour.

Levitt¹,

Selkoe²,

Frankenfield³

et al. 1975

Journal of Neurology, Neurosurgery & Psychiatry

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“…Survival analysis revealed that advanced age was associated with significantly lower survival (Figure 2 COMMENT Despite the increasing incidence of primary malignant brain tumors among the elderly, relatively few studies [17][18][19][20][21] have addressed clinical trends among this age group, particularly in recent years. Our study confirmed that the clinical presentation of elderly patients is markedly different from their younger counterparts.…”

Section: Patients With Glioblastoma Multiformementioning

confidence: 99%

Brain Tumors in the Elderly

Lowry¹,

Snyder²,

Lowry³

1998

Arch Neurol

105

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“…First, elderly patients tend to have higher grade astrocytomas [4,9,10]. Second, astrocytic neoplasms in this age group rarely occur in the cerebellum [4]. Third, the prognosis of patients in the older population with intracranial astrocytic neoplasms is poor [9,11].…”

Section: Discussionmentioning

confidence: 99%

“…Cancer is preeminently a disease whose incidence rises with age. A review of the literature [2][3][4][5][6] specifically dealing with brain tumors occurring in this particular age group surprisingly revealed limited information on those with intracranial astrocytomas.…”

Section: Introductionmentioning

confidence: 99%

Intracranial astrocytoma in elderly patients

1992

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Because little is known about intracranial astrocytomas occurring in those in the increasing geriatric population, twenty-three persons evaluated at the university affiliated hospitals over a 26-year period are reported. Progressive mental dysfunctions and motor deficits were the most common manifestations of disease. Glioblastoma multiforme was the predominant (87%) histopathologic diagnosis. The overall median period of survival in 21 evaluable individuals was four (range 0 to 15) months. Median survival was longer in patients who were more functional, who had tumors located in the temporal lobes of the brain, and who received more than one treatment modality. The absence of intercurrent disease or being in a younger 'elderly' age group was not associated with an improvement in prognosis. The poor survival of this group as well as the survivals quoted in the literature for those with glioblastoma multiforme demands a new therapeutic approach.

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Tumors of the Brain in Aged Persons

Cited by 34 publications

References 5 publications

Pure motor hemiplegia secondary to brain-stem tumour.

Pure motor hemiplegia secondary to brain-stem tumour.

Brain Tumors in the Elderly

Intracranial astrocytoma in elderly patients

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