Tumors of the digestive tract

Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool

“…Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all PC cases [ 21 ], has a highly complex cytogenetic profile that involves all chromosomes and includes both numerical and unbalanced structural aberrations [ 22 , 23 ]. This high complexity and the extensive intratumor cytogenetic heterogeneity are assumed to be a consequence of the advanced disease stage at the point of cytogenetic analysis [ 23 ].…”

“…Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all PC cases [ 21 ], has a highly complex cytogenetic profile that involves all chromosomes and includes both numerical and unbalanced structural aberrations [ 22 , 23 ]. This high complexity and the extensive intratumor cytogenetic heterogeneity are assumed to be a consequence of the advanced disease stage at the point of cytogenetic analysis [ 23 ]. In an analysis of six cytogenetic studies including 127 PDAC cases, several recurrent numerical aberrations were observed, including monosomy 18 (in 60% of cases), monosomies 4, 6, 9, 12, 17, 21, 22, X and Y, and trisomies 7 and 20 (in 25–38% of cases).…”

“…In an analysis of six cytogenetic studies including 127 PDAC cases, several recurrent numerical aberrations were observed, including monosomy 18 (in 60% of cases), monosomies 4, 6, 9, 12, 17, 21, 22, X and Y, and trisomies 7 and 20 (in 25–38% of cases). The most common recurrent breakpoints were 13q10, 19q13, 1q10, 8q10, 14q10, 17p11 and 17q10, with frequencies of up to 13% [ 23 ]. A more recent cytogenetic study that included 48 PDAC cases detected deletions on 17p, 18q, 21q, and the pericentromeric region of chromosome 18 (CEP18), and gains on 7q and 20q [ 24 ].…”