Tumors of the Esophagus

Das, Ananya

doi:10.1016/b978-1-4160-6189-2.00046-9

Cited by 2 publications

(4 citation statements)

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“…ESCC develops by progression from dysplastic lesions within the squamous epithelium of the oesophagus ( Das, 2010 ). In other words, oesophageal squamous dysplasia (ESD) is the histological precursor lesion for ESCC ( Dawsey et al , 1994b ; Wang et al , 2005 ).…”

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confidence: 99%

“…Endoscopy with Lugol's iodine staining and biopsy is the most accurate method for diagnosing ESD ( Dawsey et al , 1998 ; Das, 2010 ). However, it is an invasive and expensive procedure, which may not be acceptable to the asymptomatic population in high-risk areas, including Golestan Province ( Roshandel et al , 2014 ), suggesting the need for other non-endoscopic screening methods.…”

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Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran

et al. 2014

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Background:Oesophageal squamous cell carcinoma (ESCC) is a fatal disease with 5-year survival rates of <5% in Northern Iran. Oesophageal squamous dysplasia (ESD) is the precursor histologic lesion of ESCC. This pilot study was conducted to assess the feasibility, safety, and acceptability of non-endoscopic cytological examination of the oesophagus and to provide initial data on the accuracy of cytological atypia for identifying patients with ESD in this very-high-risk area.Methods:Randomly selected asymptomatic participants of the Golestan Cohort Study were recruited. A cytological specimen was taken using a capsule sponge device and evaluated for atypical cells. Sections of the cytological specimen were also stained for p53 protein. Patient acceptability was assessed using a visual analogue scale. The cytological diagnosis was compared with a chromoendoscopic examination using Lugol's solution.Results:Three hundred and forty-four subjects (43% male, mean (s.d.) age 55.6 (7.9) years) were referred to the study clinic. Three hundred and twelve met eligibility criteria and consented, of which 301 subjects (96.5%) completed both cytological and endoscopic examinations. There were no complications. Most of the participants (279; 92.7%) were satisfied with the examination. The sensitivity and specificity of the cytological examination for identifying subjects with high-grade ESD were 100 and 97%, respectively. We found an accuracy of 100% (95% CI=99–100%) for a combination of cytological examination and p53 staining to detect high-grade ESD.Conclusions:The capsule sponge methodology seems to be a feasible, safe, and acceptable method for diagnosing precancerous lesions of the oesophagus in this population, with promising initial accuracy data for the detection of high-grade ESD.

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Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran

et al. 2014

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“…Verrucous carcinoma of the esophagus (VCE) is a rare malignant epithelial tumor representing a variant of squamous cell carcinoma [ 1 ]. It was first reported in 1967 by Minielly et al [ 2 ].…”

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confidence: 99%

“…Under the microscope well-differentiated squamous cells with minimal to low atypia are seen. In addition, hyperkeratosis, nonspecific inflammation and obvious acanthosis can be seen [ 1 , 6 ]. Endoscopically, hypoechoic wall thickening is seen from nodular to concentric in appearance, penetrating from the mucosa to the submucosa, with frequent invasion into the muscularis propria layer [ 3 , 4 , 5 , 7 ].…”

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Verrucous Carcinoma of the Esophagus: A Potential Diagnostic Dilemma

Ahmed¹,

Timmerman²,

Meyer

et al. 2013

Case Rep Gastroenterol

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Verrucous carcinoma of the esophagus is a rare variant of squamous cell carcinoma associated with human papillomavirus. We report the case of a 58-year-old female who presented with ongoing symptoms of dysphagia. On previous endoscopies she had been noted to have a large polyp-like mass involving the esophagus, with negative biopsies for malignancy. Repeat endoscopy with concurrent endoscopic ultrasound showed a large semi-pedunculated polyp in the distal esophagus and a hypoechoic, irregular mass involving the gastroesophageal junction with esophageal thickening. Deep layer biopsies showed pseudoepitheliomatous hyperplasia with immunohistochemical staining positive for human papillomavirus. The patient was subsequently treated with chemo-radiation followed by esophagectomy.

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Tumors of the Esophagus

Cited by 2 publications

References 215 publications

Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran

Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran

Verrucous Carcinoma of the Esophagus: A Potential Diagnostic Dilemma

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