Tumors of the Gallbladder

Qian, You–Wen

doi:10.1007/978-981-10-3536-4_9

Cited by 1 publication

(1 citation statement)

References 76 publications

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“…[6,7] Approximately 80% of GBCs involved in the liver were invasive when they were diagnosed, since the GB subserosa is weak, and there is no peritoneal covering on the contacting surface with the liver. [8] Because of the insidious onset, rapid progression, and advanced stage at diagnosis, GBC has a poor prognosis with an overall 5-year survival rate of less than 5%. However, a 5-year survival rate of 75% can be reached if stage-adjusted therapy is performed in the early stages.…”

Section: Introductionmentioning

confidence: 99%

Differentiating benign from malignant gallbladder wall thickening in non-contrast MRI imaging: Preliminary study of a combined diagnostic indicator

Zhu

Pylypenko³

et al. 2022

Medicine

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To synthetically evaluate the diagnostic accuracy of image features for differentiating benign from malignant gallbladder wall thickening disease with non-contrast MRI and establish the optimal diagnostic indicator. A total of 23 patients with wall thickening type gallbladder carcinoma and 61 patients with benign wall thickening disease were included. The diagnostic performance of six image features including the layered pattern on T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) images, T2WI signal intensity, papillary growth, the apparent diffusion coefficient (ADC) value, and the lesion to liver parenchyma ratio (LLR) of gallbladder were evaluated and compared. The receiver operating characteristic (ROC) curve and binary logistic regression analysis were used to construct the optimally combined indicator. All six indicators showed high diagnostic accuracy. The layered pattern on DWI and LLR had the highest area under the curve (AUC) value (0.904), followed by the layered pattern on T2WI (0.883), T2WI signal intensity (0.859), ADC value (0.836), and papillary growth (0.796). There was no statistically significant difference in the AUC among indicators for pairwise comparisons. A combination of layered patterns on DWI and papillary growth was shown to be the optimal indicator by binary logistic regression analysis. The AUC value of the combination (0.972) was higher than the layered pattern on DWI (0.904) and papillary growth (0.796) (P < .001). Non-contrast MRI provides several reliable indicators for differentiating benign from malignant gallbladder thickening disease. The combination of layered patterns on DWI and papillary growth is the optimal indicator.

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Section: Introductionmentioning

confidence: 99%