Tumors of the Musculoskeletal System

Leonardi, Leonardo

doi:10.1007/978-3-030-90210-0_2

Cited by 3 publications

(12 citation statements)

References 212 publications

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Section: Introductionmentioning

confidence: 99%

“…Extraskeletal Osteosarcoma (EOS) is a primitive osseous sarcoma defined by the production of osteoid or immature bone but arising in tissues other than bone without skeletal involvement ( 1 – 3 ). EOSs have been described in a variety of animal species and several tissues and organs such as the mammary gland first for frequency, followed by the spleen, skin and subcutis, intestine, muscle, liver ( 4 ), thyroid gland, urinary system, and salivary glands ( 1 , 3 ). Like osteosarcomas of skeletal origin, extraskeletal osteosarcomas generally present as rapidly growing infiltrative masses, with areas of ossification at different stages of maturation, often also mixed with necrosis and hemorrhagic necrosis ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…EOSs have been described in a variety of animal species and several tissues and organs such as the mammary gland first for frequency, followed by the spleen, skin and subcutis, intestine, muscle, liver ( 4 ), thyroid gland, urinary system, and salivary glands ( 1 , 3 ). Like osteosarcomas of skeletal origin, extraskeletal osteosarcomas generally present as rapidly growing infiltrative masses, with areas of ossification at different stages of maturation, often also mixed with necrosis and hemorrhagic necrosis ( 1 ). Histologically, EOSs resemble skeletal osteosarcomas, with a frequent local recurrence and a high metastatic potential.…”

Section: Introductionmentioning

confidence: 99%

“…EOSs have been diagnosed according to WHO guidelines and based on the primary location of the tumors and the certainty that the tumor is primitive from soft tissue and not from skeletal tissue. In dogs EOSs represent a highly malignant tumor with only <1 month median survival time after the first diagnosis ( 1 , 5 ). A definitive histological diagnosis of osteosarcoma may not be straightforward, due to the high variability in cellular density of these tumors.…”

Section: Introductionmentioning

confidence: 99%

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Canine soft tissue sarcomas: the expression of RUNX2 and karyopherin alpha-2 in extraskeletal (soft tissues) and skeletal osteosarcomas

Leonardi,

Manuali,

Bufalari

et al. 2024

Front. Vet. Sci.

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Extraskeletal osteosarcoma (EOS) is a malignant tumor producing bone matrix and/or chondroid material, without direct attachment to bone or periosteum. In humans and dogs, EOS is highly infiltrating, rapidly growing, often characterized by osteoid deposition and variable ossification, similar to primary skeletal osteosarcoma (SOS). In dogs, EOS arises from visceral and soft tissue locations, occasionally in trauma or foreign body sites, or in granulomas. Few data are currently available on the phenotype of these tumors. The present study aims to assess the expression RUNX2 and Karyopherin alpha-2 in EOS, comparing it with SOS and the data available from the human counterpart. Seventeen cases of canine osteosarcoma (13 EOS and 4 SOS) were retrospectively selected and submitted to immunohistochemistry for RUNX2 and Karyopherin alpha-2. Our results showed that, in EOS, RUNX2 is expressed in a mean of 73.07 ± 5.36 neoplastic cell nuclei, in face of a mean 36.15 ± 6.25 of Karyopherin alpha-2 positive nuclei. Osteoclasts, when present, were negative for both markers. No correlation was observed among the two markers (p > 0.05), nor statistically significant difference in quantitative expression was assessed comparing EOS and SOS groups. RUNX2 is expressed in canine EOS similarly to SOS and could be used as a diagnostic marker in a larger panel. Karyopherin alpha-2 is expressed in canine EOS and SOS similarly to human SOS and could be validated in future studies as an additional diagnostic marker. Further studies should be planned to evaluate the expression of these proteins as prognostic predictive parameters.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Canine soft tissue sarcomas: the expression of RUNX2 and karyopherin alpha-2 in extraskeletal (soft tissues) and skeletal osteosarcomas

Leonardi,

Manuali,

Bufalari

et al. 2024

Front. Vet. Sci.

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“…Osteosarcoma is a highly malignant bone neoplasia, characterized by the proliferation of mesenchymal cells and the production of woven bone tissue and osteoid matrix ( Leonardi, 2022 ). It can originate from bone, which is the most common presentation, and can be divided into axial and appendicular forms.…”

Section: Introductionmentioning

confidence: 99%

Primary omentum extraskeletal osteosarcoma in a dog: case report

Soares,

Medeiros,

Martins

2023

Braz. J. Vet. Med.

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A rescued male mixed-breed dog, approximately nine years old, was evaluated due to progressive weight loss and an enlarged abdomen. An ultrasound revealed a large, indeterminate mass with mineral-like margins visible on the radiographs. The animal underwent an exploratory laparotomy, and the mass was excised. Histopathological analysis revealed characteristics consistent with a primary omentum extraskeletal osteosarcoma. This rare neoplasm, originating from mesenchymal cell proliferation and bone matrix production, is highly malignant. It often results in death due to metastasis and local recurrence or necessitates euthanasia post-diagnosis in certain cases.

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Köpek ve kedilerde primer kemik tümörleri: 98 vaka

TUNÇ,

FİLİKCİ,

SAĞLAM

et al. 2024

Veteriner Hekimler Derneği Dergisi

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The aim of this study is to contribute to the current literature by determining the distribution of bone tumors in dogs and cats by breed, age, gender and location. Bone tumors are more common in dogs than cats, and the most common primary bone tumor in both species is osteosarcoma. The biopsy and necropsy reports of the Ankara University, Faculty of Veterinary Medicine, Department of Pathology , were retrospectively studied examining for cases of primary bone tumors in dogs and cats. This study's period encompassed from 2001 through 2020 (20 years). A total of 98 bone tumors were detected 70 in dogs and 28 in cats. Of the cases in dogs, 13 (18.57%) were necropsy, while 57 (81.43%) were biopsy. Sex distribution of bone tumors is in female dogs (n:28, 40%) and in male dogs (n:38, 54.29%). Also, females (n:17, 60.7%) and males (n:11, 39.3%) were observed in cats. in dogs, although 57.14% (n=40) were purebreds and 31.43% (n=22) were mongrel breeds, in cats, 75% of them were mongrel (n=21) and 7.1% (n=2) were purebred. While locations of tumors in dogs were appendicular (65.71%, n=46), axial (30%, n=21), locations of tumors in cats were appendicular (50%, n=14), axial (39.29%, n=11) and both appendicular and axial (10.71%, n:3). While 13 benign (18.57%) and 57 malignant (81.43%) tumors were observed in dogs, 4 benign (14.29%) and 24 malignant (85.71%) tumors were observed in cats. The data were analyzed in the SPSS program and no significant relationship was detected between the data (P>0.05). This study would contribute and conduce the comparative oncology for dogs and cats.

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Tumors of the Musculoskeletal System

Cited by 3 publications

References 212 publications

Canine soft tissue sarcomas: the expression of RUNX2 and karyopherin alpha-2 in extraskeletal (soft tissues) and skeletal osteosarcomas

Canine soft tissue sarcomas: the expression of RUNX2 and karyopherin alpha-2 in extraskeletal (soft tissues) and skeletal osteosarcomas

Primary omentum extraskeletal osteosarcoma in a dog: case report

Köpek ve kedilerde primer kemik tümörleri: 98 vaka

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