Tumors of the Skin and Subcutaneous Tissues

Hauck, Marlene; Oblak, Michelle L.

doi:10.1016/b978-0-323-59496-7.00019-0

Cited by 15 publications

(15 citation statements)

References 130 publications

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“…Another report also observed an overall response rate of 89% (CR + PR) among cats with acceptable adverse effects with a median time to progression of 30.5 months 6 . The treatment for cSCC is primarily surgical when feasible; however, to achieve clean surgical margins to gain good local control, an aggressive surgical excision is usually indicated 7 , 19 – 21 . In a series report of 61 cats treated with surgery, radiotherapy, and cryosurgery, the surgery group had the longest median DFI of 19.8 months in cats with noninvasive disease 22 .…”

Section: Discussionmentioning

confidence: 99%

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Comparison of two different doses of bleomycin in electrochemotherapy protocols for feline cutaneous squamous cell carcinoma nonsegregated from ultraviolet light exposure

Anjos

Sierra

Spugnini³

et al. 2020

Sci Rep

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Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin tumors in cats due to chronic exposure to ultraviolet light. Local treatments such as electrochemotherapy (ECT) promote disease control or even complete remission. We hypothesize that cats could benefit from treatments using bleomycin at reduced dosages. A prospective nonrandomized single-blind study evaluated the clinical parameters, site lesion, staging, disease-free interval (DFI) and survival time by comparing the standard dose of bleomycin (15,000 UI/m2) (n = 22) with a reduced dose (10,000 UI/m2) (n = 34) in cats with cSCC that underwent ECT as the sole treatment modality. No statistically significant difference in DFI or overall survival was observed between the 2 groups. A higher DFI was found in cats with a small tumor size (less than 0.33 cm3) compared with that for cats with a large tumor size (P = 0.045). Furthermore, a reduced overall survival time for cats with a higher stage in the standard group SG (T3 and T4) (P = 0.004) was observed when compared to that for cats with a lower stage (T1 and T2). In conclusion, ECT using both doses of bleomycin may achieve the same response rate in terms of the overall response, DFI, and overall survival.

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Section: Discussionmentioning

confidence: 99%

“…Cutaneous squamous cell carcinoma (cSCC) accounts for 10% of skin tumors in cats due to chronic exposure to ultraviolet (UV) light 1 , 2 . The lesions usually develop in pale or unpigmented skin with white areas being at the greatest risk 3 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of two different doses of bleomycin in electrochemotherapy protocols for feline cutaneous squamous cell carcinoma nonsegregated from ultraviolet light exposure

Anjos

Sierra

Spugnini³

et al. 2020

Sci Rep

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“…Massen des Gehörkanals im felinen Patienten entstehen am häufigsten aus dem Epithel des Meatus acusticus externus -häufiger im vertikalen als im horizontalen Anteil -und seltener aus dem Gehörgangsknorpel [1]. Diese werden aufgrund des Masseneffekts, der zu klinischen Symptomen einer chronischen Otitis oder partieller Taubheit führen kann, diagnostiziert [2].…”

Section: Umfangsvermehrungen Des Gehörkanalsunclassified

“…Katzen mit kutanen Mastzelltumoren -unabhängig ob solitär oder multipel -sollten mittels abdominaler Ultraschalluntersuchung und zytologischer Untersuchung auf Anzeichen einer Infiltration der abdominalen Organe, insbesondere von Milz und Leber, untersucht werden [1,6,7]. Außerdem sollte eine zytologische Untersuchung der lokalen und regional relevanten Lymphknoten auf Anzeichen einer Metastasierung sowie eine Blutuntersuchung durchgeführt werden [2].…”

Section: Feline Mastzelltumorenunclassified

Ungewöhnlicher Mastzelltumor im Gehörgang einer Katze

Castelli,

Hey,

Rieker

et al. 2024

Tierarztl Prax Ausg K Kleintiere Heimtiere

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ZusammenfassungEin 12 Jahre alter kastrierter Europäisch Kurzhaarkater wurde aufgrund von Juckreiz im Bereich des rechten Ohres, Blutungen aus dem Gehörgang und einer polypösen Masse in dessen Lumen vorgestellt.Nach Bestätigung der Masse durch eine klinische und otoskopische Untersuchung wurde als weitere Diagnostik eine Computertomografie des Kopfes und des Brustkorbs in Vollnarkose durchgeführt. Die beiden Mittelohren waren unauffällig, die regionalen Lymphknoten und der Brustkorb zeigten keine Veränderungen gegenüber der Norm.Im Anschluss an die Bildgebung wurde die Umfangsvermehrung bioptiert.In Rahmen des Stagings wurde nach der histopathologischen Diagnose eines Low Grade-Mastzelltumors eine Ultraschalluntersuchung des Abdomens und ein komplettes Blutbild durchgeführt. Am selben Tag wurde eine totale Gehörgangsablation durchgeführt und der entfernte Gehörgang wiederum zur histopathologischen Beurteilung der Ränder eingesendet. Die Schnittränder waren „im Gesunden“. Die Katze wurde 14 Monate nach der chirurgischen Behandlung eingeschläfert. Es bleibt unklar, ob es die Folge einer Metastasierung des ursprünglichen Mastzelltumor war.Ein Mastzelltumor im Gehörgang ist ein ungewöhnlicher Befund, der jedoch als Differentialdiagnose bei Umfangsvermehrungen im Gehörgang in Betracht gezogen werden sollte.

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“…White-haired cats have an increased risk of developing cSCC than other hair colors as they lack the protection of melanin. More than half of the cats with nasal planum cSCC have mutations of the tumor-suppressor gene p53, indicating that a genetic predisposing factor may have an important role in the development of the disease [ 3 - 5 ] . Interestingly, HPV has been isolated from cSCC in cats, supporting that it can contribute in the same way to the disease development [ 6 ] .…”

Section: Introductionmentioning

confidence: 99%

Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

Tellado¹,

Michinski²,

Impellizeri³

et al. 2022

Cancer Drug Resist

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Aim: Cutaneous squamous cell carcinoma (cSCC) is a common disease in patients exposed to UV-light and human papillomavirus. Electrochemotherapy, a well-established treatment modality with minimum side effects in human and veterinary medicine, circumvents chemoresistance to bleomycin by the use of electric fields. However, patients are sensitive to the trauma produced by the insertion of the needles that lengthen recovery times, particularly cats with nasal planum cSCC. To address this matter, we developed thin-needles electrodes. Methods: Thin-needles electrodes developed using computer simulations and plant tissue models were compared to standard electrodes. A prospective non-randomized study recruiting 52 feline patients with nasal planum cSCC was performed. Local response, anorexia, and overall survival were evaluated. Results: Computer simulations and plant model experiments showed satisfactory results with both electrodes. The patients treated with the thin-needle electrode obtained similar local response rates compared to the standard group, OR 97.3% vs. 80%, respectively (P < 0.067). Most patients in the thin-needle group resumed eating in less than 48 h, as the anorexia was significantly lower (P < 0.0001). Using the standard electrode, most patients took 3 to 5 days to resume normal feeding. The electric current circulating in the standard electrode was 44% higher, contributing to a longer duration of anorexia due to tissue damage. The overall survival in both groups was similar. Conclusion: Electrochemotherapy using thin-needle electrodes provides equivalent local response rates and overall survival compared with standard electrodes but significantly reduced return to appetite after the treatment. These results may be useful in the development of new electrodes for human patients.

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Tumors of the Skin and Subcutaneous Tissues

Cited by 15 publications

References 130 publications

Comparison of two different doses of bleomycin in electrochemotherapy protocols for feline cutaneous squamous cell carcinoma nonsegregated from ultraviolet light exposure

Comparison of two different doses of bleomycin in electrochemotherapy protocols for feline cutaneous squamous cell carcinoma nonsegregated from ultraviolet light exposure

Ungewöhnlicher Mastzelltumor im Gehörgang einer Katze

Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

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