Tumors of the small intestine

Botsford, Thomas W.; Crowe, Peter T.; Crocker, Diane W.

doi:10.1016/0002-9610(62)90226-x

Cited by 102 publications

(25 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Benign lesions of the small intestine in themselves are a rarity and Brunner's gland hamartoma constitutes a small part of these lesions [1–3]. Botsford et al observed one Brunner's gland adenoma in a study of 115 primary tumors of the small intestine [10]. In a study of 615 benign and malignant duodenal specimens, 2.5% constituted Brunner's gland hyperplasia and 1.4% Brunner's gland hamartoma [11].…”

Section: Discussionmentioning

confidence: 99%

A Giant Brunneroma Causing Gastrointestinal Bleeding and Severe Anemia Requiring Transfusion and Surgery

Frenkel

Rinkes

Molenaar

et al. 2017

Case Reports in Surgery

View full text Add to dashboard Cite

Brunner's gland hamartoma, also called hyperplasia, adenoma, and Brunneroma, is an extremely rare benign proliferative lesion of Brunner's glands in the duodenum. While being mostly small and asymptomatic, they can result in gastrointestinal bleeding and obstruction. We report the case of a 54-year-old man presenting with melena and severe anemia requiring blood transfusion. CT scans showed a large mass of 8 cm in diameter, presumably arising in the duodenum. Endoscopic biopsies were not conclusive. As we were unable to determine the nature of the mass preoperatively and due to the severe symptoms, its size, and the uncertain malignant potential, a classic Whipple procedure was performed. The resected specimen showed extensive proliferation of Brunner's glands without signs of malignancy.

show abstract

Section: Discussionmentioning

confidence: 99%

A Giant Brunneroma Causing Gastrointestinal Bleeding and Severe Anemia Requiring Transfusion and Surgery

Frenkel

Rinkes

Molenaar

et al. 2017

Case Reports in Surgery

View full text Add to dashboard Cite

show abstract

“…1 Various nomenclatures have been used to describe these tumors including Brunner's gland harmartoma, adenoma, and "Brunneroma." Fryter analyzed over 2 800 duodenal specimens and described three types of hyperplastic proliferation of the Brunner's glands, namely, diffuse, nodular, and adenomatous.…”

Section: Discussionmentioning

confidence: 99%

“…1 Although initially an anatomical curiosity, the report of a 29-year-old woman with fatal duodenal intussusception from Brunner's gland hyperplasia brought to light its clinical significance. Since then, this condition has only rarely been described in the medical literature.…”

Section: Introductionmentioning

confidence: 98%

Giant Brunneroma as an Unusual Cause of Upper Gastrointestinal Hemorrhage: Report of a Case

Tan

Wong

2002

Surgery Today

View full text Add to dashboard Cite

Brunneroma, also known as Brunner's gland adenoma or harmartoma, is a rare, benign, proliferative lesion arising from the Brunner's glands of the duodenum, usually discovered incidentally at endoscopy. Occasionally, these lesions manifest as a rare cause of duodenal obstruction or upper gastrointestinal hemorrhage, and require excision. We report a case of an unusually large Brunneroma in a patient who presented with fresh melena and anemia. Although endoscopic polypectomy is the treatment of choice, we decided to perform surgical polypectomy through a laparotomy due to the huge dimensions of the lesion. The clinical and endoscopic features of this benign tumor and the therapeutic options are critically reviewed.

show abstract

“…Brunner's gland hamartomas and adenomas account for up to 1% of small bowel tumours. 1 Normal Brunner's glands are alkaline mucus-secreting and are found predominantly in the duodenum, extending to the proximal jejunum. 2 Brunner's gland hamartomas are most often found in the proximal duodenum (57%), 2 representing the normal Brunner's gland distribution.…”

Section: Discussionmentioning

confidence: 99%

Malignant potential in a Brunner’s gland hamartoma

Brookes

Manjunatha

Allen³

et al. 2003

Postgraduate Medical Journal

View full text Add to dashboard Cite

Postgrad Med J 2003;79:416-417 Brunner's gland hamartomas are rare tumours of the duodenum. These lesions have previously been described as being benign, with no malignant potential. A case report is presented of a Brunner's gland hamartoma, whose histology revealed a focus of well marked epithelial dysplasia. This case suggests a dysplastic stage in the natural history of Brunner's gland hamartoma, and questions the malignant potential of these lesions. Brunner's gland hamartomas are rare duodenal tumours and an unusual cause of gastrointestinal bleeding. Since the first description of a Brunner's gland hamartoma in 1876 there has been controversy to the aetiology and pathogenesis of this lesion. Several case reports have described these lesions as non-dysplastic and entirely benign. However a case report is presented, representing a Brunner's gland hamartoma with a dysplastic focus. This case report illustrates that these lesions do appear to become dysplastic and raises the question of malignant potential. CASE REPORTA 79 year old white man presented with a collapse and melaena. He had a history of stable angina for three years, mild chronic obstructive pulmonary disease, and a previous transient ischaemic attack. He was taking 75 mg of aspirin daily and took minimal alcohol. Examination revealed a soft non-tender abdomen and a blood pressure of 114/75 mm Hg, with no significant postural drop. Haematological investigations revealed anaemia, with a haemoglobin concentration of 92 g/l. On the second day the haemoglobin dropped to 72 g/l and an upper gastrointestinal endoscopy was performed.At endoscopy a 2 cm pedunculated lesion, with an ulcerated crater, was noted in the second part of the duodenum (fig 1). There were no signs of active bleeding and the lesion was biopsied at this stage. The patient was transfused and subsequently maintained his haemoglobin.Histology revealed a submucosal lesion with complex, crowded architecture and features consistent with a Brunner's gland hamartoma. However, in the deeper layers of the specimen, some nuclear atypia with occasional mitotic figures was seen. Given these findings a repeat endoscopy was performed and the lesion was removed by snare polypectomy using coagulation current.Histology of the resected specimen revealed it to predominantly composed of lobules of relatively bland appearing Brunner's glands. However throughout the specimen there were foci of obvious dysplasia with some foci showing more pronounced cytological changes (fig 2). DISCUSSIONDuodenal tumours, both malignant and benign, are rare. Brunner's gland hamartomas and adenomas account for up to 1% of small bowel tumours.1 Normal Brunner's glands are alkaline mucus-secreting and are found predominantly in the duodenum, extending to the proximal jejunum.2 Brunner's gland hamartomas are most often found in the proximal duodenum (57%), 2 representing the normal Brunner's gland distribution. The majority are pedunculated (88%), 2 and are commonly 1-2 cm in diameter. Clinical presentation is variable, an...

show abstract

Tumors of the small intestine

Cited by 102 publications

References 6 publications

A Giant Brunneroma Causing Gastrointestinal Bleeding and Severe Anemia Requiring Transfusion and Surgery

A Giant Brunneroma Causing Gastrointestinal Bleeding and Severe Anemia Requiring Transfusion and Surgery

Giant Brunneroma as an Unusual Cause of Upper Gastrointestinal Hemorrhage: Report of a Case

Malignant potential in a Brunner’s gland hamartoma

Contact Info

Product

Resources

About