Tumors of the submandibular gland: Clinicopathologic analysis of 23 patients

Rapidis, Alexander D.; Stavrianos, S.; Lagogiannis, George; Faratzis, G.

doi:10.1016/j.joms.2003.12.033

Cited by 67 publications

(47 citation statements)

References 17 publications

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“…The lining epithelial cells of the ducts, tubules, and acini then differentiate morphologically and functionally, and the contractile myoepithelial cells arrange themselves around the acini (8,9). The mesenchyme is responsible for genesis of the capsule and connective parotid tissue (10,11).…”

Section: Introductionmentioning

confidence: 99%

Glycomic profile of the human parotid gland between 18th and 26th week of fetal development

Rego¹,

Filho²,

Sobral

et al. 2016

J Oral Sci

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The formation of new and functional structural components of several organs, such as parotid glands, can be influenced by the glycocode. This study analyzed the glycobiology of parotid salivary gland tissue during fetal development using specific biochemical probes (lectins and antibodies). Eleven parotid gland samples from human fetuses were obtained from spontaneous abortions at 14-28 weeks of gestation, and tissue sections were analyzed for lectin histochemistry and immunohistochemistry. From the 18th to 26th week, Canavalia ensiformis agglutinin, wheat germ agglutinin, Ulex europaeus agglutinin-I, peanut agglutinin, Sambucus nigra agglutinin, and Vicia villosa agglutinin lectin staining were predominantly observed in the apical and/or basement membranes of the ducts and tubulo-acinar units. Moreover, the presence of galectin-1 was found in the membrane, cytoplasm, and nucleus of both structures. Conversely, Gal-3 and mucin-1 were restricted to the glandular ducts. The lectin staining pattern changed during the weeks evaluated. Nevertheless, the carbohydrate subcellular localization represented a key factor in the investigation of structural distribution profiles and possible roles of these glycans in initial parotid gland development.

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Section: Introductionmentioning

confidence: 99%

Glycomic profile of the human parotid gland between 18th and 26th week of fetal development

Rego¹,

Filho²,

Sobral

et al. 2016

J Oral Sci

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“…This tumor presents itself as a painless and slow growing nodule that can reach great dimensions without compromising the adjacent anatomical structures [1][2][3][4][5]. Proper treatment is only achieved when the correct diagnose is obtained.…”

Section: Discussionmentioning

confidence: 99%

“…However, due to the lack of a typical histological pattern and to the morphological variety of myoepithelial neoplasms, fine needle aspiration biopsy, incisional biopsy or frozen biopsy are useful in the differentiation from malignant lesions, but do not always provide for a definitive diagnosis. This confirmation is only obtained from the histopathologic examination of the entire specimen, associated with clinical and image information [4][5][6][7]. Treatment success is directly related with total removal of the gland.…”

Section: Discussionmentioning

confidence: 99%

“…A rare occurrence is its multiple manifestation within the gland, around 2.6%, presenting as multicentric or multifocal. Besides the rarity, this variant represents a determinant characteristic for the recurrence potential, either because of the greater number of lesions or due to its invasive nature [1][2][3][4][5]. This paper reports a case of a pleomorphic adenoma originating from the submandibular gland, in which surgical interventions demonstrated a multicentric behavior of the lesion.…”

Section: Introductionmentioning

confidence: 99%

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Pleomorphic Multicentric Adenoma in the Submandibular Gland

Alves

Júnior

Borba

et al. 2007

Head and Neck Pathol

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Neoplasms of salivary glands represent a small group among the diseases involving the head and neck complex. In this group, the pleomorphic adenoma is the most frequent neoplasm, yet involves the submandibular gland in only 12.3% of cases. A patient presenting a swelling in the region of the submandibular gland was submitted to an incisional biopsy, where a fragment of the gland and one juxtaposed node were removed. Histologically they were defined as pleomorphic adenoma. Later, the patient was submitted to submandibulectomy and two other nodes were found close to the gland and removed. All specimens were histologically defined as pleomorphic adenoma. This multicentric finding is of great interest, perhaps explaining the recurrence rate of this neoplasm. The patient is in continuous follow-up and has not presented signs of recurrence.

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“…They found that pleomorphic adenoma was the most frequent benign tumor and manifest a mild course of disease. 5 Adeyemo et al reviewed a total of 36 patients submandibular salivary gland tumors over a 17 years, out of which 17 cases were benign and 19 cases were malignant. pleomorphic adenoma (36.1%) was the most frequent tumor, followed by adenoid cystic carcinoma (11.1%), anaplastic carcinoma (11.1%) and malignant lymphoma (11.1%).…”

Section: Introductionmentioning

confidence: 99%

Pleomorphic adenoma of submandibular gland: not so common occurrence

et al. 2018

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INTRODUCTIONSalivary gland tumors are uncommon and comprise only 1-4% of head-face-neck tumors. Majority of the salivary gland tumors affect parotid gland with more than 70% of the cases. Several studies have been conducted on the tumors of the parotid and minor salivary glands, but very few reports in the literature have focused on submandibular gland tumors as they are rare and are usually grouped with other salivary glands. Submandibular gland is affected in 5-10% of the cases with pleomorphic adenoma being the most common tumor. 1The most frequent neoplasms in the submandibular glands are: pleomorphic adenoma (36%), adenoid cystic ABSTRACT Background: The salivary glands tumour are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes. Several studies have been conducted on the tumors of the parotid and minor salivary glands, but very few reports in the literature have focused on submandibular gland tumors as they are rare and are usually grouped with other salivary glands. Approximately 70% of the salivary gland tumors affect parotid gland with the submandibular gland being affected in 5-10% of the cases, sublingual gland in 1% and minor glands in 5-15% of the cases. So, author describe a series of 50 patients of pleomorphic adenoma affecting submandibular gland. Methods: The prospective study was conducted at Department of General Surgery, Indira Gandhi Government Medical College, Nagpur between January 2008 to December 2017. Results: Out of the 50 patients, 10 were male and 40 were female. Thus, male to female ratio is 1:4. Most of the 42 (84%) patients presented with painless swelling in submandibular region. Clinically the tumour has the texture of cartilage and has an irregular and bosselated surface observed in all the patients. The size of tumour was 3 to 6 cm in 32 (64%) patients observed in the present study. Fine needle aspiration cytology was performed in all the patients. All patients were managed by surgical excision. Recurrence occurred in a single patient who was managed with radical excision including a neck dissection with postoperative radiotherapy. Conclusions: Submandibular gland pleomorphic adenoma being common benign tumor, occurring commonly between the 3 rd and 5 th decade of life and presenting as slow growing asymptomatic swelling with female preponderance. The precise surgical excision along with whole submandibular salivary gland and postoperative radical radiotherapy required for recurrence as the accepted mode of management. However, further long-term studies involving submandibular gland have to be carried out to know the pattern of tumor recurrence.

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Tumors of the submandibular gland: Clinicopathologic analysis of 23 patients

Cited by 67 publications

References 17 publications

Glycomic profile of the human parotid gland between 18th and 26th week of fetal development

Glycomic profile of the human parotid gland between 18th and 26th week of fetal development

Pleomorphic Multicentric Adenoma in the Submandibular Gland

Pleomorphic adenoma of submandibular gland: not so common occurrence

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