Tumors of the surface epithelium

Calonje, Eduardo; Brenn, Thomas; Lazar, Alexander J.

doi:10.1016/b978-1-4160-5649-2.00024-x

Cited by 30 publications

(72 citation statements)

References 1,424 publications

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“…Two cases of atypical lipomatous tumors (well‐differentiated liposarcomas) presenting as benign skin tags have been reported by Paredes et al In an isolated case, a patient had a buttocks ‘growth’ for 15 years that was clinically consistent with a giant acrochordon and subsequent biopsy revealed verrucous carcinoma . Additionally, fibroepithelioma of Pinkus, a likely variant of basal cell carcinoma, clinically resembles an acrochordon . In the majority of these cases, either the clinical appearance of the acrochordon was atypical or the patient had a suspicious medical history.…”

Section: Discussionmentioning

confidence: 99%

“…21 Additionally, fibroepithelioma of Pinkus, a likely variant of basal cell carcinoma, clinically resembles an acrochordon. 22 In the majority of these cases, either the clinical appearance of the acrochordon was atypical or the patient had a suspicious medical history. Such experiences of malignant processes involving clinical acrochordons have led some to promote microscopic examination of all acrochordons, especially lesions that appear clinically irritated.…”

Section: Discussionmentioning

confidence: 99%

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Mycosis fungoides involving an acrochordon: a case report

et al. 2012

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We present the case of a 77-year-old male undergoing treatment for mycosis fungoides (MF) who presented for removal of an acrochordon on his mid back. Histopathologic examination of the acrochordon revealed a dense, band-like lymphocytic inflammatory infiltrate in the dermis with epidermotropism of single lymphocytes and small nests of lymphocytes into the lower epidermis. Immunohistochemical staining characterized the dermal and epidermal lymphocytic population as CD3-positive T lymphocytes with a predominance of CD4-positive over CD8-positive lymphocytes. These findings were consistent with the patient's known MF and molecular identification of a clonal T-cell receptor gene rearrangement further supported the diagnosis. Our unusual case reports MF involving an acrochordon and provides evidence to support the importance of submitting acrochordons for histopathologic examination.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides involving an acrochordon: a case report

et al. 2012

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“…All patients were Caucasians, and the detailed characteristics of the study group are summarized in Appendix 1. SCCs were graded by four-tiered system as well (Grade 1), moderately (Grade 2) poorly differentiated (Grade 3) and anaplastic or undifferentiated tumors (Grade 4) [8]. Data for the SCCs were collected by using the CAP (The College of American Pathologists) protocols for squamous carcinoma of the skin (www.cap.org).…”

Section: Study Groupsmentioning

confidence: 99%

Metastasis suppressor proteins in cutaneous squamous cell carcinoma

Bozdoğan

Vargel

Çavuşoğlu

et al. 2016

Pathology - Research and Practice

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Cutaneous squamous cell carcinomas (cSCCs) are common human carcinomas. Despite having metastasizing capacities, they usually show less aggressive progression compared to squamous cell carcinoma (SCC) of other organs. Metastasis suppressor proteins (MSPs) are a group of proteins that control and slow-down the metastatic process. In this study, we established the importance of seven well-defined MSPs including NDRG1, NM23-H1, RhoGDI2, E-cadherin, CD82/KAI1, MKK4, and AKAP12 in cSCCs. Protein expression levels of the selected MSPs were detected in 32 cSCCs, 6 in situ SCCs, and two skin cell lines (HaCaT, A-431) by immunohistochemistry. The results were evaluated semi-quantitatively using the HSCORE system. In addition, mRNA expression levels were detected by qRT-PCR in the cell lines. The HSCOREs of NM23-H1 were similar in cSCCs and normal skin tissues, while RGHOGDI2, E-cadherin and AKAP12 were significantly downregulated in cSCCs compared to normal skin. The levels of MKK4, NDRG1 and CD82 were partially conserved in cSCCs. In stage I SCCs, nuclear staining of NM23-H1 (NM23-H1nuc) was significantly lower than in stage II/III SCCs. Only nuclear staining of MKK4 (MKK4nuc) showed significantly higher scores in in situ carcinomas compared to invasive SCCs. In conclusion, similar to other human tumors, we have demonstrated complex differential expression patterns for the MSPs in in-situ and invasive cSCCs. This complex MSP signature warrants further biological and experimental pathway research.

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“…Cellular atypia is infrequent in most cases of BCC, excluding the rare pleomorphic (giant cell) type of BCC, but mitoses and apoptotic cells are frequent [31]. Interestingly, nuclear atypia and multiple mitoses do not alter the clinical course of BCC [32].…”

Section: Histopathologymentioning

confidence: 99%

Reviews Basal cell carcinoma – diagnosis

Mackiewicz-Wysocka¹,

Bowszyc‐Dmochowska²,

Strzelecka-Węklar³

et al. 2013

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Basal cell carcinoma is the most common skin cancer in the Caucasian population. The cancer arises in sun exposed areas of the skin. The incidence of morbidity is high and it is still growing. The metastatic rate is low, but the enlarging tumor may cause severe tissue disfigurement and a poor cosmetic outcome. The diagnosis is usually clinical but there are many subtypes of this carcinoma and correct diagnosis is the clue to appropriate treatment of the lesion. The main problem in basal cell carcinoma management is the high recurrence rate.

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Tumors of the surface epithelium

Cited by 30 publications

References 1,424 publications

Mycosis fungoides involving an acrochordon: a case report

Mycosis fungoides involving an acrochordon: a case report

Metastasis suppressor proteins in cutaneous squamous cell carcinoma

Reviews Basal cell carcinoma – diagnosis

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