Tumors of the urethra in men and women

Abstract

A study of urethral tumors in men and women has been made. The 3 most important tumors involving the male urethra are: 1. those arising in the meatus and parameatal area; 2. squamous cell cancer of the membranous urethra; and 3. transitional cell cancer of the prostatic urethra. The latter 2 respond poorly to any and all forms of therapy regardless of extent of ablative surgical attempt or radiation therapy dosage. Tire' latter prostatic urethral tumor is also hormone‐resistant. The most common tumors of the female urethra are epidermoid carcinoma and adenocarcinoma. Tumors of the distal urethra may be successfully treated by partial urethrectomy or by irradiation. For proximal or entire urethral tumors, the prognosis with radiation or surgery alone is poor; combined radiation and surgery is preferable.

Mucin-producing urothelial-type adenocarcinoma of prostate: report of two cases of a rare and diagnostically challenging entity

“…1 Obstructive symptoms due to a urethral mass or stricture are the usual presenting features. 2,3 Chronic irritation, infection, and trauma, including that from instrumentation used to relieve strictures, are the major predisposing factors. 1,2 In one series, 37% of patients had a history of venereal disease, 35% had stricture, and 7% had suffered trauma.…”

“…1,2 In one series, 37% of patients had a history of venereal disease, 35% had stricture, and 7% had suffered trauma. 3 It has been reported that up to 88% of patients with urethral carcinoma have a history of urethral stricture. The most common site for stricture, the bulbomembranous urethra, is also the most common location for carcinoma.…”

Intracranial metastasis from primary transitional cell carcinoma of female urethra: case report & review of the literature

“…It has been regarded that urethral carcinoma is the only urological cancer that is more common in female than in male [14]. However, in a large population-based study, the incidence of primary urethral carcinoma is relatively higher in men and black population in the United State [2].…”

Primary transitional cell carcinoma of the anterior urethra: a rare presentation.

“…Only five cases have been reported inthe literature up to the end of December 1988.' Urothelial metaplasia or ectop-ic urothelium may explain the occurrence of transitional cell carcinoma in an area normally lined by squamous epithelium.2" However, the isolation of human papilloma virus type 6 RNA in three cases of Grade I papillary transitional cell carcinoma of the anterior urethra in association with condyloma acuminata raises the possibility of an active role for the virus in the pathogenesis of the lesion. 4 Here we report a case of transitional cell carcinoma of the anterior urethra presenting with features consistent with periurethral inflammation and review the related literature.…”