Tumors of the Urinary System

Meuten, Donald J.

doi:10.1002/9780470376928.ch10

Cited by 64 publications

(91 citation statements)

References 88 publications

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“…Tubular carcinoma is considered the most common histologic pattern in RCCs of domestic animals. 11 However, in this series, papillary carcinoma was the most common pattern; 9 tumors had papillary differentiation, whereas only 3 had predominantly tubulopapillary differentiation. In accordance with the literature, 11 all tumors had a mixture of histologic patterns, and necrosis was identified in all but one case.…”

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confidence: 52%

“…3,13 Other canine renal epithelial neoplasms include renal adenoma, oncocytoma, transitional cell carcinoma, papilloma, and squamous cell carcinoma. 11 RCC is more common in male middle-aged dogs (8 to 9 years old), without breed predilection. 8 Metastatic disease is detected by thoracic radiography in 50% of dogs at presentation.…”

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confidence: 99%

“…12 Unfortunately, classification by histologic or cytologic criteria is not predictive of biological behavior in domestic animals. 11 The immunohistochemical characterization of human RCC has proved useful in refining tumor classification and notions about its biological behavior. 1 The purpose of this study was to correlate the immunohistochemical profile of 13 canine RCCs with histologic classification.…”

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confidence: 99%

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Immunohistochemical Characterization of 13 Canine Renal Cell Carcinomas

Costa¹,

Oliveira

Saraiva³

et al. 2010

Vet Pathol

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Canine renal cell carcinomas (RCCs) are uncommon aggressive tumors that occur mainly in middle-aged male dogs. Their histologic classification bears no relationship with prognosis, and little information is available concerning their immunohistochemical properties. In this retrospective study, formalin-fixed, paraffin-embedded tissues from 13 canine RCCs were retrieved from the archives, classified histologically, and evaluated immunohistochemically. The dogs were 7 males and 6 females (1 spayed) of 10 different breeds, averaging 8 years in age. The tumors were classified as papillary, tubulopapillary, papillary-cystic, solid, or sarcomatoid. All 13 tumors were immunohistochemically positive for uromodulin, 12 for c-KIT, 11 for vimentin, 9 for wide-spectrum-screening cytokeratins, 7 for cytokeratins AE1/AE3 and carcinoembryonic antigen, 4 for cytokeratins CAM 5.2, and 3 for CD10. All 3 solid RCCs expressed vimentin, c-KIT, and carcinoembryonic antigen and were negative for cytokeratins. All 7 papillary and tubulopapillary tumors expressed vimentin; 6 (86%), cytokeratins; and 6 (86%), c-KIT. Both papillary-cystic RCCs were positive for cytokeratins and c-KIT and negative for vimentin. These results indicate that the different histologic types of RCC have characteristic immunohistochemical profiles and that c-KIT may be involved in the pathogenesis of canine RCC.

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confidence: 52%

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confidence: 99%

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confidence: 99%

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Immunohistochemical Characterization of 13 Canine Renal Cell Carcinomas

Costa¹,

Oliveira

Saraiva³

et al. 2010

Vet Pathol

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“…According to review literature there was no report in camelide about vascular calcification and maybe this is due to their age. Renal adenoma is rare tumor in domestic animals and when found it usually is an incidental lesion at necropsy or slaughter because these tumors are clinically silent [19] . Also this case was related to a camel which slaughtered.…”

Section: Discussionmentioning

confidence: 99%

“…They form tubules and acini that may be subclassified as tubular, papillary, or solid based on the major histopathological pattern: central or elongated lumen (tubular type); papillary growth of varying sizes that project into lumens (papillary) or solid sheets. Mixtures of all three types can occur [19] . In this case mixtures of tubular and papillary form were seen and solid sheets were absent.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Investigations on Renal Lesions in Slaughtered Camel (Camelus dromedarius) in North East of Iran

Rezaie¹,

Mostafazadeh²,

Anbari³

et al. 2014

Kafkas Univ Vet Fak Derg

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SummaryCamel can tolerates water deprivation conditions more than two months. Kidneys are vital organs in this case. The objective of this study is recognition of kidney lesions. In this study 38 samples of kidney were collected from slaughter house of Tabbas and Mashhad. Specimens were fixed in 10% neutral buffered formalin for at least 24 hours and then routinely processed and then the sections were stained with Haematoxylin and Eosin (H&E), special staining and immunohistochemistry. Histopathological study revealed different lesions and the most common were glomerulonephritis. Other lesions were acute tubular necrosis (ATN), renal cyst and interstitial nephritis. Vascular calcification was significant lesions which were characterized with basophilic material in the intima of vessels. Renal adenoma was diagnosed in one camel and according to review literature it is the first report in camel. Camel is a comparatively hardy animal and is less susceptible to many of the diseases that affect other livestock species in the same area [1] . However, it is apparent that we know too little about the diseases from which it does suffer. In different reports, tubulonephrosis due to DNA virus [2] and Ricketsia-like organisms [3] , glomerulonephritis due to aflatoxicosis [4] , glomerulonephritis and interstitial nephritis [5] were described. Kidney lesions, especially nephritis, are major diseases of domestic animals. Outbreaks occur in camel, cattle, buffaloes and small ruminants in various countries of the world. This study was conducted with the objective of identifying the types of histopathological kidney lesions of slaughtered camels in north east of Iran.Tumours have been rarely documented in captive camelids. In the Arabian dromedary (Camelus dromedarius) there have been reports of an ovarian teratoma [6] ,

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Renal Neoplasia

Henry¹

2011

Nephrology and Urology of Small Animals

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Tumors of the Urinary System

Cited by 64 publications

References 88 publications

Immunohistochemical Characterization of 13 Canine Renal Cell Carcinomas

Immunohistochemical Characterization of 13 Canine Renal Cell Carcinomas

Histopathological Investigations on Renal Lesions in Slaughtered Camel (Camelus dromedarius) in North East of Iran

Renal Neoplasia

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