Tumour Angiogenesis: The Relevance to Surgeons

Atkin, G E; Chopada, A

doi:10.1308/003588406x117106

Cited by 10 publications

(17 citation statements)

References 38 publications

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“…Our series provides evidence of neoplastic behaviour in two instances: one, rapid regrowth of a previously resected tumour with identical histology and secondly, life threatening haemorrhage following angiogenesis either via co-option or neoangiogenesis. The latter, a quality associated with neoplasia rather than a developmental disorder [28,29].…”

Section: Discussionmentioning

confidence: 99%

Difficulties in the management of mesenchymal hamartomas

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Difficulties in the management of mesenchymal hamartomas

et al. 2008

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“…This step is influenced by an interaction of many factors and ends up in vessel remodelling and matrix stabilisation of the newly formed capillary [135,136].…”

Section: Influence Of Isoflavones On Angiogenesismentioning

confidence: 99%

“…The stages of neovascularisation (BM, basement membrane); produced by kind permission of Atkin and Chopada[135].…”

mentioning

confidence: 99%

Isoflavones are safe compounds for therapeutical applications – Evaluation ofin vitrodata

Reiter

Beck

Medjakovic

et al. 2009

Gynecological Endocrinology

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Isoflavone-rich food and food supplements have gained increasing popularity also in the Western world. Their weak estrogenic effect has been considered as a potential risk, although all epidemiological studies and clinical trials show a significant cancer protection and decreased risk of cardiovascular diseases. In vitro data suggest that the concerted action of the isoflavones and their metabolites show antiproliferative behaviour, reduce angiogenesis, reduce tumor progression and exert antiinflammatory effects. For the evaluation of the biological effects, special emphasis has to be put on the concerted action between the isoflavones and their metabolites. For instance, while isolated genistein shows some growth promoting effect at low concentrations, the metabolite equol or soy extract show growth retardation as well as higher concentrations of genistein do. The isoflavones have multiple affinities to other members of the steroid hormone receptor superfamily. The beneficial effect on metabolic diseases and weight reduction by isoflavone consumption can be partly explained by its affinity for the PPAR family. In light of the in vitro experiments, together with the epidemiological observations and the clinical experience, isoflavones can be considered as safe compounds and their consumption as food and food supplements has to be promoted.

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“…VEGFC binds to its receptor VEGFR3 and promotes lymphatic hyperplasia and lymphangiogenesis [ 13 , 23 , 24 ]. FGF1 has also been shown to possess proangiogenic properties [ 12 , 25 ] and IL8 is another established proangiogenic cytokine [ 26 , 27 ]. However, the greatest amplification of genes was seen with SPHK1, EGF and VEGFC.…”

Section: Discussionmentioning

confidence: 99%

“…It is therefore thought that surgery might affect cancer cell dormancy and trigger angiogenesis [ 6 - 9 ]. Currently, several studies have focused on angiogenesis in breast cancer [ 10 , 11 ] but only a few have investigated the kinetics of the best known circulating pro-angiogenic molecules in blood or fluid from wound drains and their expression in cancer tissue [ 12 - 15 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of breast cancer surgery on angiogenesis circulating biomarkers: a prospective longitudinal study

et al. 2013

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BackgroundDebate about the potential effects that surgery might have on cancer cells dormancy and angiogenesis prompted us to investigate the impact of breast surgery on circulating angiogenesis modulating gene transcripts and proteins.MethodsBlood samples from 10 female patients diagnosed with breast cancer and 6 with fibroadenoma were collected before surgery and post-operatively on days 3 and 7 (breast cancer patients only). A set of 84 angiogenesis-associated transcripts were assessed using quantitative PCR arrays, and circulating protein levels (vascular endothelial growth factor A (VEGFA), IL8 and fibroblast growth factor 2 (FGF2) were measured using ELISA in the same samples. The results were investigated against clinicopathological data and patient outcome.ResultsPlasma levels of VEGFA and IL8 after surgery were significantly elevated in the breast cancer group compared to the control group (P = 0.038 and P = 0.021, respectively). In the cohort of breast cancer patients, VEGFA increased on day 3 (P = 0.038) and declined on day 7 (P= 0.017), while IL8 did not change on day 3 but showed a significant decline on day 7 (P = 0.02). FGF2 levels did not change significantly over time. Regarding gene transcripts, we detected upregulation of a significant number of angiogenesis-specific genes in patients with breast cancer versus controls: sphingosine kinase 1(SPHK1), epidermal growth factor (EGF), vascular endothelial growth factor C (VEGFC), neuropilin 1 (NRP1), fibroblast growth factor (FGF1), laminin alpha 5 (LAMA5), collagen type IV alpha 3 (COL4A3), IL8, ephrin B2 (EFNB2), ephrin A3 (EFNA3), tyrosine endothelial kinase (TEK), integrin beta 3 (ITGB3), AKT1, thrombospondin 1 (THBS1), chemokine (C-C motif) ligand 11 (CCL11) and TIMP metallopeptidase inhibitor 3 (TIMP3). Surgery induced an altered expression in several keygenes in breast cancer patients. We identified an upregulation of COL4A3 and downregulation of chemokine (C-X-C motif) ligand 9 (CXCL9), EGF, FGF1, Kinase insert domain receptor (KDR), Placental growth factor (PGF), TIMP3 and VEGFC.ConclusionBreast cancer patients have a different expression profile of circulating angiogenesis biomarkers compared to patients with fibroadenoma. Moreover, mastectomy promotes a transient increase of VEGFA and a shift in the expression patterns of a broad panel of angiogenesis-related circulating gene transcripts.

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Tumour Angiogenesis: The Relevance to Surgeons

Abstract: As the use of these anti-angiogenic therapies becomes more wide-spread, they may have implications on the healing rates of cutaneous wounds and intracorporeal anastomoses.

Cited by 10 publications

References 38 publications

Difficulties in the management of mesenchymal hamartomas

Difficulties in the management of mesenchymal hamartomas

Isoflavones are safe compounds for therapeutical applications – Evaluation ofin vitrodata

Impact of breast cancer surgery on angiogenesis circulating biomarkers: a prospective longitudinal study

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