Tumour-associated immune responses and isolated carcinoembryonic antigen and alpha feto-protein levels related to survival in ovarian cancer patients

Levin, Larissa V.; McHardy, J E; Poulton, T. A.; Curling, O. M.; Kitau, M. J.; Neville, A. Munro; Hudson, Chris

doi:10.1038/bjc.1976.60

Cited by 12 publications

(2 citation statements)

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“…(1978). Elevated serum CEA levels merely reflect increased tumour burden (Levin et at., 1976;Seppala et a/., 1975) and not a greater aggressiveness of the tumour as compared to those tumours that do not produce CEA.…”

Section: Discussionmentioning

confidence: 99%

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Tissue CEA in premalignant epithelial lesions and epidermoid carcinoma of the uterine cervix: Prognostic significance

Lindgren

Wahlström

Seppälä

1979

Intl Journal of Cancer

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Carcinoembryonic antigen (CEA) was studied by the indirect triple-bridge immunoperoxidase method in formalin-fixed paraffin-embedded tissue specimens from 191 patients with premalignant epithelial lesions or epidermoid carcinoma of the uterine cervix treated 12 years ago. The frequency of tissue CEA positivity was found to increase with advancing clinical disease in the following manner: mild dysplasia, 25%; severe dysplasia, 37%; carcinoma in situ, 60%; invasive carcinoma stage I, 60%; stage IIa, 65%; stage IIb, 80%; and stages III and IV, 69%. The prognostic significance of the tissue CEA positivity was studied in two groups of patients formed on the basis of clinical spread and treatment of the disease. The first group of 60 patients with stage I and IIa cancers had undergone radical surgery. The second group of 44 patients with more advanced carcinoma had been treated by radiotherapy alone. No significant difference in the survival rates was observed in either group between patients with CEA-positive and CEA-negative tumours. In the light of the absence of CEA from normal cervical epithelium, the increasing occurrence of CEA from premalignant lesions to advancing malignant growth suggests that CEA reflects an aggressive potential in premalignant lesions. However, the survival data on patients with CEA-positive and -negative invasive carcinomas suggest that CEA-positive cancers are not more malignant than CEA-negative cancers.

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Section: Discussionmentioning

confidence: 99%

“…Elevated serum levels of carcinoembryonic antigen (CEA) have been regarded as an unfavourable prognostic sign in malignant disease (Levin et a/., 1976). While elevated serum CEA levels appear to correlate with the total tumour burden in the organism, it is not known whether CEA-positive tumour cells are more aggressive than those that d o not express CEA.…”

mentioning

confidence: 99%

Tissue CEA in premalignant epithelial lesions and epidermoid carcinoma of the uterine cervix: Prognostic significance

Lindgren

Wahlström

Seppälä

1979

Intl Journal of Cancer

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Tumor markers in inclusion cysts of the ovary

Blaustein

Kaganowicz

Wells

1982

Cancer

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The immunoperoxidase method was used to determine whether carcinoembryonic antigen, beta subunit of HCC placental lactogen, pregnancy-associated alpha-2 glycoprotein, and pregnancy-specific beta-1 glycoprotein could be found in inclusion cysts of the ovary. These tumor markers are found in the serum of patients with common epithelial carcinomas of the ovary and inclusion cysts are considered to be the origin of these tumors. Placental lactogen was found in 56 of 118 inclusion cysts, beta subunit of HCG in four of 141 cysts, alpha-2 glycoprotein in five of 141, and beta-1 glycoprotein in two of 118. It was concluded that primitive cells in inclusion cysts elaborate the same tumor markers found in serous cystadenoma and cystadenocarcinoma of the ovary. This observation, although not proving origin of tumor from the inclusion cyst, demonstrates a significant characteristic shared in common by all three. Cancer 49722-726, 1982. T HAS BEEN NOTED that malignancies of the ovary are able to synthesize and secrete ectopic proteins that These ma-are specific to the fetus and lignancies included common epithelial carcinomas of the ovary. Khoo and MacKay' reported that significantly raised values of CEA were found in the serum of 77% of patients with cystadenocarcinoma. Stone et d. I 4 reported that about one-half of beta subunit HCG determinations were positive in the sera of 26 patients with serous, mucinous, and endometrioid carcinoma. Similar studies by Crowther et d4 have shown the presence of pregnancy-associated alpha-2 glycoprotein, pregnancy-specific beta-1 glycoprotein, and placental lactogen in the blood of patients with mucinous, serous, endometrioid, and undifferentiated carcinomas. Because these tumors are believed to originate in inclusion cysts in the cortex of the ovary," it seemed worthwhile to investigate, through the use of the im-munoperoxidase method, whether any of the above ec-topic proteins, widely regarded as tumor markers, could be found in the cytoplasm of cells making up the cysts.

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Ovarian and Uterine Cancer Markers

Seppälä

1982

Human Cancer Markers

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Tumour-associated immune responses and isolated carcinoembryonic antigen and alpha feto-protein levels related to survival in ovarian cancer patients

Cited by 12 publications

References 8 publications

Tissue CEA in premalignant epithelial lesions and epidermoid carcinoma of the uterine cervix: Prognostic significance

Tissue CEA in premalignant epithelial lesions and epidermoid carcinoma of the uterine cervix: Prognostic significance

Tumor markers in inclusion cysts of the ovary

Ovarian and Uterine Cancer Markers

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