Tumour-Associated Transplantation Antigens of Neoplasms Induced by a Naturally Occurring Murine Sarcoma Virus (FBJ-MSV)

Jones, David B.; Moore, Michael G.

doi:10.1038/bjc.1973.52

Cited by 6 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanics of radiation-induced apoptosis resistance has been a subject of investigation for the last 50 years. Early studies have attempted to identify resistance mechanisms to radiation in OS through the acquisition of immunity against radiation 4,5 . These studies have hypothesized that murine models of OS could be sensitized to radiation therapies if immunized with antibodies against OS.…”

Section: Genomic Mechanisms Of Resistance To Radiation-induced Apoptomentioning

confidence: 99%

Resistance mechanisms in the radiation therapy of osteosarcoma: a brief review

Koutsomplia¹,

Lambrou²

2020

JRPMS

View full text Add to dashboard Cite

LocationOsteosarcoma's location with regard to primary tumors is typically unique to intramedullary, metaphyseal regions of Abstract Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Osteosarcoma is a very aggressive type of tumor, which has devastating effects on the patient. Especially, pediatric patients suffering from osteosarcoma, are very vulnerable to its side-effects. Most patients suffering from osteosarcoma have a very poor prognosis and thus the understanding of its mechanisms, both oncogenetic as well ontogenetic are of crucial importance. The stagnancy of clinical outcomes may is explained by heterogeneity and complexity as well as genetic background. Not many studies have dealt with the molecular mechanisms of resistance to radiation therapy in osteosarcoma, yet the main genes proposed for their participation include p53, p21, NF-κB, RAS, Rb and GRIM-19. In addition, recent studies have highlighted the role of epigenetic mechanisms in osteosarcoma resistance to therapy and in particular the role of miRNAs. Due to the devastating effect of the disease to the suffering patients, more studies are required in order to unravel the radiation-induced cell death resistance.

show abstract

Section: Genomic Mechanisms Of Resistance To Radiation-induced Apoptomentioning

confidence: 99%

Resistance mechanisms in the radiation therapy of osteosarcoma: a brief review

Koutsomplia¹,

Lambrou²

2020

JRPMS

View full text Add to dashboard Cite

show abstract

“…These antigens fall into two distinct categories: (a) the Gross (G) or "w 'ild" type antigen found in Passage A (Gross) virus-induced, and many spontaneous leukaemias as well as in normal tissues of high leukaemic strains (Old, Boyse and Stockert, 1965;Aoki, Boyse and Old, 1966 (XVahren, 1963;Klein and Klein, 1964;Old, Boyse and Stockert, 1964). Previous studies undertaken with tumours induced by MSV-FBJ have established that in common with sarcomata induced by other MSV isolates (Fefer, McCoy and Glynn, 1967;Law, Ting and Stanton, 1968;Koldovsky, Turano and Fadda, 1969;McCoy et al, 1972) these neoplasms are immunogenic in syngeneic hosts (Jones and Moore, 1973). The induction of cellmediated immunity is paralleled by the concomitant appearance of antibodies to virus type-specific antigens in the serum of immune mice, and less consistently in the serum of tumour-bearing mice (Jones and Moore, 1974 Moore, 1974).…”

mentioning

confidence: 97%

Antigens of Tumours Induced by Naturally Occurring Murine Sarcoma Virus (MSV-FBJ)

Jones¹,

Moore²

1974

Br J Cancer

View full text Add to dashboard Cite

Summary.-Cell surface antigens expressed by cells transformed in vivo by FBJ virus, a wild type murine sarcoma virus (MSV) complex derived from a spontaneously arising sarcoma in a CF1 mouse, have been studied by indirect membrane immunofluorescence (MIF). Using mouse antisera raised by immunization of syngeneic CBA mice with transplanted FBJ sarcomata an antigen common to all FBJ tumours was detected which was also present on Gross (G) antigen positive tissues, viz. leukaemic and preleukaemic AKR lymphoid cells, but absent from the tissues of mice of G negative strains. Failure to demonstrate antigenic crossreactivity in reciprocal MIF tests using FBJ immune sera and antisera to MSV-H (Harvey), an MSV isolate of Friend-Moloney-Rauscher (FMR) sub-group specificity, established the virus type-specificity of antigens expressed by sarcoma cells transformed by the respective MSV.The presence of a cellular antigen with G specificity on FBJ sarcoma cells was confirmed in tests with aged exbreeding C57B1 antisera containing naturally occurring G antibody lacking significant virus neutralizing activity. However, evidence for a " sarcoma-non-leukaemia " antigen on cells transformed by MSV-FBJ was not obtained since absorption studies failed to reveal any specificity on FBJ sarcoma cells which was not also present on AKR leukaemic tissues.It is suggested that the major humoral component of the immune response to FBJ sarcoma cells is evoked against antigens specified by the associated nonpathogenic leukaemia virus (MLV-FBJ) and the relationship of antigens demonstrated by MIF to those detected previously by complement fixation (CF) and tumour rejection tests is discussed.FBJ VIRUS, a murine sarcoma virus 1973). Immunological studies have estab-(MSV-FBJ) isolated in association with a lished that the FBJ viruses possess the non-pathogenic murine leukaemia virus group-specific (gs) antigens of murine (MLV-FBJ) from a spontaneously arising leukaemia virus (MLV) and the type sarcoma in a CFI mouse (Finkel, Biskis specificity of the Gross (G) or wild type and Jinkins, 1966), bears a close morpho-subgroup of murine oncorna-viruses, logical and biochemical relationship to by contrast with other MSV isolates other members of the RNA murine leu-(e.g. MSVT-Harvey) of Friend-Moloneykaemia-sarcoma virus complex (Biskis and Rauscher (FMR) subgroup specificity Finkel, 1969;Rhim et al., 1969; Levy et al., (Kelloff et al., 1969; Jones and Moore, * Present address (for reprints):

show abstract

“…Tumours induced in the laboratory by preparations containing oncogenic virus have TATA of variable strength, though these are not individualistic but common to the tumours induced and determined by the particular virus. However, some viruses are reported to produce little TATA (Jones and Moore, 1973) and no report has been traced of significant TATA in the prototype viral lymphoma (Gross) of AKR mice with vertical inheritance of virus.…”

mentioning

confidence: 99%

Radiation leukaemogenesis: is virus really necessary?

Loutit¹,

Ash²

1978

Br J Cancer

View full text Add to dashboard Cite

Generalized lymphosarcomatosis (leukaemia) of non-thymic type occurs in mice bearing 90Sr or 239Pu or 226Ra. Tumours passaged from such mice have been tested for tumour-associated transplantation antigens that could provoke a protective immunity which would be expected if such antigens were determined by virus activated by the irradiation. Sub-threshold doses of living syngeneic tumour, large doses of living allogeneic tumour and large doses of killed syngeneic tumour were without protective effect. This suggests that viruses observed electron micrographically in such tumours are passengers and not causative. Images Fig. 1 Fig. 2 Fig. 3

show abstract

Tumour-Associated Transplantation Antigens of Neoplasms Induced by a Naturally Occurring Murine Sarcoma Virus (FBJ-MSV)

Cited by 6 publications

References 24 publications

Resistance mechanisms in the radiation therapy of osteosarcoma: a brief review

Resistance mechanisms in the radiation therapy of osteosarcoma: a brief review

Antigens of Tumours Induced by Naturally Occurring Murine Sarcoma Virus (MSV-FBJ)

Radiation leukaemogenesis: is virus really necessary?

Contact Info

Product

Resources

About