Tumour characteristics of bilateral screen-detected cancers and bilateral interval cancers in women participating at biennial screening mammography

Bommel, Rob van; Lameijer, Joost R. C.; Voogd, Adri C.; Louwman, Marieke W. J.; Setz-Pels, Wikke; Strobbe, Luc J. A.; Tjan‐Heijnen, Vivianne C. G.; Duijm, Luciën E. M.

doi:10.1016/j.ejrad.2018.09.026

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…As for the clinicopathological features, study suggested that index cancers of bilateral screen-detected cancers and bilateral interval cancers show signi cant differences in tumour size, whereas nodal status, receptor status and nal surgical treatment are comparable [15]. Our study showed that the clinicopathological characteristics of screen-detected NPBC in those (N + Contra) PBC patients were similar to those of BiNPBC (Table 2).…”

Section: Discussionsupporting

confidence: 58%

Long-term Survival of Screen-Detected Synchronous and Metachronous Bilateral Non-Palpable Breast Cancer among Chinese women: A Hospital-Based Study (2003-2017)

Pan

Zhou

et al. 2022

Preprint

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Purpose: Screen-detected unilateral non-palpable breast cancer (NPBC) shows favorable prognosis whereas bilateral breast cancer (BBC), especially synchronous BBC (SBBC) manifests worse survival than unilateral breast cancer (BC). It remains unclear whether screen-detected bilateral NPBC has compromised survival and requires intensified treatment or favorable prognosis and needs de-escalating therapy.Methods: From 2003 to 2017, data from 1,075 consecutive patients with screen-detected 1,107 NPBCs were retrospectively reviewed. There were 988 patients with unilateral NPBC (UniNPBC), and 87 patients with bilateral BC [(N+AnyContra) PBC], including 32 patients with bilateral NPBC (BiNPBC) and 55 patients with ipsilateral NPBC + contralateral palpable cancer [(N+Contra) PBC]. Follow-up time was 48-227 (median 91) months. Clinicopathological characteristics, relapse-free survival (RFS) and overall survival (OS) were compared between UniNPBC and BBC and among synchronous or metachronous BBC subgroups. RFS and OS factors of BBC were identified.Results: Compared to UniNPBC, patients with screen-detected bilateral BC had more invasive, ER negative, PR negative, triple-negative BC as well as less breast conserving surgery, radiotherapy and endocrine therapy. In terms of 10-year RFS and OS rates, BiNPBC, synchronous (SynBiNPBC) and metachronous BiNPBC (MetaBiNPBC) showed similar good prognosis as UniNPBC. However, survival of (N+AnyContra) PBC, (N+Contra) PBC and synchronous (N+Contra) PBC were significantly compromised. RFS factors of BBC included pN3 (p=0.048), lymphovascular invasion (p=0.008) and existence of contralateral palpable interval BC (p=0.008) while the OS relevant factor was pN3 (p=0.018).Conclusion: Screen-detected bilateral NPBC including SynBiNPBC and MetaBiNPBC showed good prognosis as UniNPBC so that the therapy of BiNPBC could be de-escalated and optimized according to UniNPBC. Contrarily, screen-detected ipsilateral NPBC with contralateral palpable BC [(N+Contra) PBC] manifested unfavorable survival worse than UniNPBC (p<0.001) and synchronous (N+Contra) PBC had the worst survival among all subgroups (p<0.001), implying that these were actually bilateral interval BC and required intensified treatment.

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Section: Discussionsupporting

confidence: 58%

Long-term Survival of Screen-Detected Synchronous and Metachronous Bilateral Non-Palpable Breast Cancer among Chinese women: A Hospital-Based Study (2003-2017)

Pan

Zhou

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…As for the clinicopathological features, study suggested that index cancers of bilateral screen-detected cancers and bilateral interval cancers show significant differences in tumor size, whereas nodal status, receptor status, and final surgical treatment are comparable [ 17 ]. Our study showed that the clinicopathological characteristics of screen-detected NPBC in those (N + Contra) PBC patients were similar to those of BiNPBC (Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

Long-term survival of screen-detected synchronous and metachronous bilateral non-palpable breast cancer among Chinese women: a hospital-based study (2003–2017)

Pan

Zhou

et al. 2022

Breast Cancer Res Treat

View full text Add to dashboard Cite

Purpose Screen-detected unilateral non-palpable breast cancer (NPBC) shows favorable prognosis, whereas bilateral breast cancer (BBC), especially synchronous BBC (SBBC) manifests worse survival than unilateral breast cancer (BC). It remains unclear whether screen-detected bilateral NPBC has compromised survival and requires intensified treatment or favorable prognosis and needs de-escalating therapy. Methods From 2003 to 2017, 1,075 consecutive NPBC patients were retrospectively reviewed. There were 988 patients with unilateral NPBC (UniNPBC), and 87 patients with ipsilateral NPBC + any contralateral BC [(N + AnyContra) PBC], including 32 patients with bilateral NPBC (BiNPBC) and 55 patients with ipsilateral NPBC + contralateral palpable cancer [(N + Contra) PBC]. Median follow-up time was 91 (48–227) months. Clinicopathological characteristics were compared between UniNPBC and BBC, whereas relapse-free survival (RFS) and overall survival (OS) among BBC subgroups. RFS and OS factors of BBC were identified. Results Compared to UniNPBC, patients with screen-detected bilateral BC had more invasive (85.1%, 74.8%), ER negative (26.4%, 17.1%), PR negative (36.8%, 23.5%), triple-negative (21.6%, 8.5%) BC as well as less breast conserving surgery (17.2%, 32.4%), radiotherapy (13.8%, 32.0%) and endocrine therapy (71.3%, 83.9%). 10 year RFS and OS rates of (N + AnyContra) PBC (72.8%, 81.5%), (N + Contra) PBC (60.6%, 73.9%), and synchronous (N + Contra) PBC (58.1%, 70.1%) were significantly compromised compared to UniNPBC (91.0%, 97.2%). RFS factors of BBC included pN3 (p = 0.048), lymphovascular invasion (p = 0.008) and existence of contralateral palpable interval BC (p = 0.008), while the OS relevant factor was pN3 (p = 0.018). Conclusion Screen-detected bilateral NPBC including SynBiNPBC and MetaBiNPBC showed good prognosis as UniNPBC so that the therapy of BiNPBC could be de-escalated and optimized according to UniNPBC. Contrarily, screen-detected ipsilateral NPBC with contralateral palpable BC [(N + Contra) PBC] manifested unfavorable survival worse than UniNPBC and synchronous (N + Contra) PBC had the worst survival among all subgroups, implying that these were actually bilateral interval BC and required intensified treatment.

show abstract

Tumour characteristics of bilateral screen-detected cancers and bilateral interval cancers in women participating at biennial screening mammography

Cited by 2 publications

References 32 publications

Long-term Survival of Screen-Detected Synchronous and Metachronous Bilateral Non-Palpable Breast Cancer among Chinese women: A Hospital-Based Study (2003-2017)

Long-term Survival of Screen-Detected Synchronous and Metachronous Bilateral Non-Palpable Breast Cancer among Chinese women: A Hospital-Based Study (2003-2017)

Long-term survival of screen-detected synchronous and metachronous bilateral non-palpable breast cancer among Chinese women: a hospital-based study (2003–2017)

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