Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis

Xu, Ying; Luan, Guangchao; Li, Zhongchao; Liu, Ziming; Qin, Guangyang; Chu, Yifu

doi:10.1007/s13402-022-00746-w

Cited by 15 publications

(12 citation statements)

References 34 publications

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“…Two mRNAs (DLAT, PDHA1) were identified, which both upregulated in HCC and led to poor prognosis of HCC patients. It has been generally accepted that ncRNAs, including miRNAs, lncRNAs, and circRNAs, participated in gene expression modulation by competing with each other via the ceRNA mechanism. − Recent studies have also experimentally verified that lncRNAs could regulate gene expression through sponging shared miRNAs, thus involving HCC progression. For example, Wang et al suggested that lncRNA MAGI2-AS3 positively regulated the expression of FOXO1 through the induction of miR-374a/b-5p, thus facilitating the proliferation, migration, and invasion of HCC cells and increasing the apoptosis of HCC cells .…”

Section: Discussionmentioning

confidence: 99%

Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma

Pan,

Zhang,

et al. 2023

ACS Omega

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The crucial role of competitive endogenous RNA (ceRNA) in the malignant biological behavior of tumors has been certificated. Nevertheless, the detailed function and molecular mechanism of ceRNA associated with cuproptosis in hepatocellular carcinoma (HCC) remains dismal. In this study, we first constructed a protein–protein interaction network and identified the module with the highest degree of aggregation degree. DLAT and PDHA1 were screened out of the module after differential expression and survival analysis. Next, we reverse-predicted the upstream miRNA and lncRNA from mRNA (DLAT, PDHA1) and successfully established the ceRNA network-SNHG3/miR-1306-5p/PDHA1. SNHG3 was identified to be an independent prognostic biomarker based on the outcome of univariate and multivariate Cox analyses. Subsequently, we implemented methylation, immune infiltration, and drug sensitivity analysis to investigate the potential biological functions of SNHG3 in HCC. In addition, SNHG3 expression was upregulated in liver cancer cell lines. In vitro functional assay revealed that SNHG3 knockdown significantly attenuated proliferation, migration, and invasion of liver cancer cells. In summary, SNHG3 exhibited oncogenic characterization via sponging miR-1306-5p to regulate PDHA1, which might function as a promising prognostic indicator and a potential therapeutic target for HCC and shed new light on the molecular mechanism of HCC progression.

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Section: Discussionmentioning

confidence: 99%

Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma

Pan,

Zhang,

et al. 2023

ACS Omega

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“…These TCs dissociated from their perivascular niche, formed a composite structure with fibrin and fibronectin, proliferated and differentiated to be stromal cells during granulation tissue formation 69 . Additionally, TCs also express measurable quantities of pro‐ angiogenic microRNAs (let‐7e, 10a, 21, 27b, 100, 126‐3p, 130a, 143, 155 and 503) 30,35 . The abovementioned indicates the involvement of TCs in neo‐angiogenesis 70 .…”

Section: Roles Of Tcs Mediated Cell Communication In Pulmonary Fibros...mentioning

confidence: 99%

“…New evidence suggested that calcification‐competent EVs from valvular interstitial cells (VICs) are regulators of calcification in diseased aortic valves and atherosclerotic plaques 34 . TC‐derived exosomes have been demonstrated crucial in maintaining intestinal stem cell function by producing exosomes that contain soluble angiogenic factors, including VEGF‐A, KLF‐4 and PDGF‐A 35 . It was revealed that TC‐EVs, carrying miR‐30b, had inhibited the WNT/beta‐catenin pathway, and had impeded osteogenesis and calcium deposition within valvular interstitial cells 36 .…”

Section: Structure Of Tc‐mediated Cell Communicationmentioning

confidence: 99%

Roles of telocytes dominated cell–cell communication in fibroproliferative acute respiratory distress syndrome

Zheng,

Cai,

Zhao

et al. 2024

Clinical and Translational Dis

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Telocytes (TCs) are a new type of interstitial cell identified in multiple tissues of mammals, including the human lung, and mediate homocellular or heterocellular cell‐cell communication. Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia respiratory failure and combined with direct and indirect lung injury, which is induced by pneumonia, sepsis, burns, etc. Pulmonary fibrosis is a progressive lung disease that occurs due to increased fibrosis of lung tissue in response to chronic injury of the epithelium and gets more and more attention as a well‐recognized sequela of ARDS or mechanical ventilation. However, the existing intervention measures could not prevent the progression of pulmonary fibrosis. Although the protective effect of TCs in acute lung injury had been demonstrated in both cellular and animal models in previous studies by our or other researchers, the roles of TCs mediated cell‐cell communication in fibroproliferative ARDS is unclear. This review is aimed at integrating our understanding of TC‐mediated cell–cell communication in lung diseases with pulmonary fibrosis after ARDS.

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“…In fact, EXo-LncSNHG16 competes with miR-942-3p/MMP9 in TCs. 138 In a study on EV signaling, Takahashi et al discovered that EV-LncRNAs moderate chemotherapy-induced cellular responses. There was a high expression of linc-ROR, a lncRNA that responds to stress in HCC cells.…”

Section: Nanovehicles For Lncrna Deliverymentioning

confidence: 99%

Nanotherapeutic approaches for delivery of long non-coding RNAs: an updated review with emphasis on cancer

Davodabadi,

Mirinejad,

Malik

et al. 2024

Nanoscale

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Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis

Cited by 15 publications

References 34 publications

Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma

Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma

Roles of telocytes dominated cell–cell communication in fibroproliferative acute respiratory distress syndrome

Nanotherapeutic approaches for delivery of long non-coding RNAs: an updated review with emphasis on cancer

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