Tumour Derived Extracellular Vesicles: Challenging Target to Blunt Tumour Immune Evasion

Lopatina, Tatiana; Sarcinella, Alessandro; Brizzi, Maria Felice

doi:10.3390/cancers14164020

Cited by 7 publications

(3 citation statements)

References 301 publications

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“…The extracellular Hsp70 may bind to specific receptor CD19 of dendritic cells (DCs), then DCs presented antigen by MHC-I to T-cytotoxic cells and induce many pro-inflammatory like IL-1 and TNFα. ExHsp70 may bind non-specifically to dendritic cells, leading to antigen presentation by MHC-II to T-helper cells and the induction of an anti-inflammatory cytokine like IL-10 [25]. Hulina and colleagues in 2018 demonstrated that exHsp70 can induce IL-1α secretion in THP-1 cells, a human leukemia monocytic cell line widely used to assess macrophage activity modulation (Fig.…”

Section: Discussionmentioning

confidence: 99%

Elevated Extracellular Hsp70 Correlates with Increased IL-1 and IL-10 in Iraqi Patients with Colorectal Carcinoma

Ismaeel,

Obaid,

Al-Saffar

et al. 2023

Iraqi j. cancer med. genet.

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Colorectal cancer (CRC) is the most common cancer in the Iraqi population. Cancerous cells are stressed cells that express large amounts of intracellular and extracellular heat shock proteins to correct for distorted proteins. They also directly affect immune cells and produce large amounts of cytokines. This work aimed to study the association between serum levels of heat shock protein 70 (Hsp70), interleukin 1 (IL-1), and interleukin 10 (IL-10) in CRC patients to highlight the importance of this pathway in patients’ immune status that may affect the progression of CRC. In the current study, an enzyme-linked immune sorbent assay (ELISA) was performed in 20 Iraqi colorectal cancer patients and 20 healthy volunteers to measure serum levels of Hsp70, IL-1α, and IL-10. Serum levels of HSP70, IL-1α and IL-10 were significantly higher in the CRC group than in the healthy control group (38.83 ± 4.7 and 14.88 ± 1.74 ng mL-1), (141.4 ± 23.22 and 46.38 ± 4.4 ng mL-1) and (26.95 ± 10.14 and 1.4 ± 1.07 ng mL-1), respectively, (p < 0.0001). According to these findings of this study, Hsp70 can be used as a prognostic biomarker for CRC and may be useful in identifying patients with an increased risk of immune tolerance and CRC development in Iraqi patients.

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Section: Discussionmentioning

confidence: 99%

Elevated Extracellular Hsp70 Correlates with Increased IL-1 and IL-10 in Iraqi Patients with Colorectal Carcinoma

Ismaeel,

Obaid,

Al-Saffar

et al. 2023

Iraqi j. cancer med. genet.

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“…Recent studies have revealed that TDEVs can reprogram cancer-infiltrated dendritic cells (DCs) toward a tumor-promoting phenotype, thereby mediating tumor immune suppression. 293 The maturation and function of DC cells depend on the composition of their contents, but TDEVs content, including HSP, TLR, HLA g, 294 S100A8, S100A9, Annexin A1, 292 PGE2, 295 TGFβ1, 296 or miRs, 297 suppress DC maturation. Normal and tumor-derived EVs have been shown to carry and transfer proteins, lipids, and nucleic acids to neighboring cells.…”

Section: Sources Of Extracellular Vesiclesmentioning

confidence: 99%

Extracellular vesicles as tools and targets in therapy for diseases

Kumar,

Baba,

Sadida

et al. 2024

Sig Transduct Target Ther

128

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Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological conditions. Human serum is a rich source of these EVs, though their isolation from serum proteins and non-EV lipid particles poses challenges. These vesicles transport various cellular components such as proteins, mRNAs, miRNAs, DNA, and lipids across distances, influencing numerous physiological and pathological events, including those within the tumor microenvironment (TME). Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents, drug delivery systems, and disease biomarkers. Especially in cancer diagnostics, EV detection can pave the way for early identification and offers potential as diagnostic biomarkers. Moreover, various EV subtypes are emerging as targeted drug delivery tools, highlighting their potential clinical significance. The need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains unfulfilled. Tapping into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the future. In this review, we discuss in detail the roles of EVs across various conditions, including cancers (encompassing head and neck, lung, gastric, breast, and hepatocellular carcinoma), neurodegenerative disorders, diabetes, viral infections, autoimmune and renal diseases, emphasizing the potential advancements in molecular diagnostics and drug delivery.

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“…However, stem cell-based therapies have their disadvantages. More than 99% of the implanted stem cells are trapped in the spleen, lung, and liver, while those cells close to the target tissues have a short life span and are prone to thrombosis, fever, and tumors [ 7 , 8 , 9 , 10 , 11 ]. Although this use of stem cells in combination with various scaffolds has long solved this problem, stem cells are still prone to cause oxidative stress and immune responses [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Experimental Study of Periodontal Ligament Stem Cells Derived Exosomes with Hydrogel Accelerating Bone Regeneration on Alveolar Bone Defect

et al. 2022

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Introduction: this study was conducted to investigate the osteogenic ability of periodontal ligament stem cells (PDLSCs) derived exosomes (PDLSCs-Exos) and the effect of PDLSCs-Exos with hydrogel on alveolar bone defect repairment in the rat. Methods: the PDLSCs were obtained through primary cell culture, and PDLSCs-Exos were purified by the ultracentrifugation method. The CCK-8 kit and ALP staining were used to explore the effect of PDLSCs-Exos on promoting the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In vivo, the alveolar bone defect models were made mesial to the bilateral maxillary first molars of rats. MicroCT, HE staining, and Masson staining were used to analyze the new bone at the bone defect of rats. Results: the periodontal ligament stem cells and the periodontal ligament stem cells derived exosomes were successfully extracted. The results of the CCK-8 kit and ALP staining showed PDLSCs-Exos significantly promoted the proliferation osteogenic differentiation of BMSCs. In vivo experiment results revealed that compared with the control group and the hydrogel group, the rats in the hydrogel with exosomes group showed more new bone formation in alveolar bone defects. Conclusion: Periodontal ligament stem cells and exosomes derived from periodontal ligament stem cells were successfully extracted. The results demonstrated that the hydrogel successfully delivered periodontal ligament stem cells derived exosomes for repairing alveolar bone defects in rats in vivo at the initial stage.

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Tumour Derived Extracellular Vesicles: Challenging Target to Blunt Tumour Immune Evasion

Cited by 7 publications

References 301 publications

Elevated Extracellular Hsp70 Correlates with Increased IL-1 and IL-10 in Iraqi Patients with Colorectal Carcinoma

Elevated Extracellular Hsp70 Correlates with Increased IL-1 and IL-10 in Iraqi Patients with Colorectal Carcinoma

Extracellular vesicles as tools and targets in therapy for diseases

The Experimental Study of Periodontal Ligament Stem Cells Derived Exosomes with Hydrogel Accelerating Bone Regeneration on Alveolar Bone Defect

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