2018
DOI: 10.1016/s1470-2045(17)30904-x
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Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy

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Cited by 1,582 publications
(1,564 citation statements)
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References 32 publications
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“…While immune infiltrates have been associated with better survival in ER-negative and HER2-positive disease, 27,28 this relationship is less clear in ER-positive/HER2-negative breast cancers, where high TIL was recently reported to be associated with shorter OS in patients treated with neoadjuvant chemotherapy. 29 Here, we identified a rare population of high TMB LumA breast cancers (12% of LumA tumors) within which the PID immune subclass predicted poor survival. To our knowledge this is the first report of clinically-relevant immune subtypes of LumA breast cancer.…”
Section: Discussionmentioning
confidence: 93%
“…While immune infiltrates have been associated with better survival in ER-negative and HER2-positive disease, 27,28 this relationship is less clear in ER-positive/HER2-negative breast cancers, where high TIL was recently reported to be associated with shorter OS in patients treated with neoadjuvant chemotherapy. 29 Here, we identified a rare population of high TMB LumA breast cancers (12% of LumA tumors) within which the PID immune subclass predicted poor survival. To our knowledge this is the first report of clinically-relevant immune subtypes of LumA breast cancer.…”
Section: Discussionmentioning
confidence: 93%
“…the HER2 and basal-like intrinsic subtypes) among whom there is an association with favorable outcomes 13 . In contrast, the more common ER+ breast cancer subtypes rarely display such heightened immune responses, which when present are associated with unfavorable prognosis 4-6 .…”
Section: Introductionmentioning
confidence: 97%
“…46 However, a meta-analysis of 13 studies and 3251 patients suggests that this association is not apparent in hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) BC. 7 Confusingly, an analysis of 3771 samples from patients enrolled in six randomized trials demonstrated that higher TIL counts were associated with decreased overall survival (OS) in HR positive BC, although TILs were associated with a higher probability for pCR in the same patients 6 Moreover, few studies have reported on TIL kinetics under NACT, with the vast majority of those comparing pre-chemotherapy samples with surgical specimens, after the completion of the entire schedule of NACT. Again, the published results are inconsistent, with studies suggesting both improved 8, 9 and worse patient outcomes 10 , 11 associated with high TIL counts after NACT.…”
Section: Introductionmentioning
confidence: 99%