Tumour necrosis factor alpha in stool as a marker of intestinal inflammation

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

“…[131][132][133] Relatives of subjects diagnosed with either Crohn's or psoriasis also have been shown to have an increased incidence of having the other disease. 134 Genetic [135][136][137][138] and pathologic [139][140][141][142] connections between these two diseases support these findings, and most recently both have been linked to specific gentotypes of IL-23. 143 Two studies have shown that psoriasis is more common in MS families than in controls.…”

Prohibitin Inhibits Tumor Necrosis Factor alpha–induced Nuclear Factor-kappa B Nuclear Translocation via the Novel Mechanism of Decreasing Importin α3 Expression

“…Caco2-BBE Cells Overexpressing PHB PHB expression is decreased in IBD patients as well as animal models of colitis (Hsieh et al, 2006;Yeo et al, 2006;Theiss et al, 2007a), whereas TNF-␣ is concomitantly increased (Murch et al, 1991;Braegger et al, 1992). We have shown that TNF-␣ not only decreases PHB promoter activation, but that NF-B is essential for this inhibition (Figure 3).…”

“…The concentration of TNF-␣ is increased in serum and stool of IBD patients (Murch et al, 1991;Braegger et al, 1992). The increased level of TNF-␣ potentiates the production of other proinflammatory cytokines, further promoting the inflammatory process.…”

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

“…The lumenal concentration of TNFa is increased in patients with in¯ammatory bowel disease (Braegger et al, 1992), a condition which predisposes to colorectal cancer (Gyde et al, 1998). Fecapentaene-12, the most abundant form of a group of mutagenic chemicals found in the faeces of individuals who consume a Western diet high in fat and meat (Schi man et al, 1989), has been shown to be a tumour promotor in a rat model of colorectal cancer (Zarcovic et al, 1993).…”