2003
DOI: 10.1046/j.1365-2222.2003.01585.x
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Tumour necrosis factor‐α‐induced expression of intercellular adhesion molecule‐1 on human eosinophilic leukaemia EoL‐1 cells is mediated by the activation of nuclear factor‐κB pathway

Abstract: In vitro studies of EoL-1 cells, an eosinophilic leukaemic cell line, confirmed that NF-kappaB plays an important role in the expression of ICAM-1 and recruitment of eosinophils in allergic inflammation.

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Cited by 16 publications
(13 citation statements)
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“…Inhibition of NF-B with MG-132 could significantly inhibit the surface expression of cytokineinduced ICAM-1 on eosinophils (Figure 4). This finding concurs with our recent data on an eosinophilic leukemic cell line, EoL-1 cells (30). Moreover, inhibition of p38 MAPK with SB 203580 could inhibit cytokine-induced Those three cytokines could, however, suppress ICAM-3 expression in vitro that was regulated by p38 MAPK but not NF-B activation ( Figure 5).…”
Section: Discussionsupporting
confidence: 93%
“…Inhibition of NF-B with MG-132 could significantly inhibit the surface expression of cytokineinduced ICAM-1 on eosinophils (Figure 4). This finding concurs with our recent data on an eosinophilic leukemic cell line, EoL-1 cells (30). Moreover, inhibition of p38 MAPK with SB 203580 could inhibit cytokine-induced Those three cytokines could, however, suppress ICAM-3 expression in vitro that was regulated by p38 MAPK but not NF-B activation ( Figure 5).…”
Section: Discussionsupporting
confidence: 93%
“…Degradation of IκB allows NF-κB to translocate into the nucleus where it can bind to κB sequences in the promoters of NF-κB-dependent genes to upregulate transcription. Recent studies have reported that activation of NF-κB mediates the transcription of ICAM-1, vascular cell adhesion molecule-1 (VCAM-1), and cytokines such as GM-CSF and IL-8 in leukocytes (10, 12). However, no information is available regarding the direct effect of D. farinae extract on the expression of adhesion molecules in human eosinophils.…”
Section: Introductionmentioning
confidence: 99%
“…IL-25 has also been shown to induce the activation of NF-B for the production chemokine IL-8 (6). Our previous studies have indicated that the activation of NF-B and p38 mitogen-activated protein kinase (MAPK) plays a role in TNF-␣activated signaling pathways regulating eotaxin release and the expression of adhesion molecules including intercellular adhesion molecule (ICAM)-1 in eosinophils (14)(15)(16). However, the IL-25-mediated intracellular signal transduction for the activation of eosinophils has not been fully studied.…”
mentioning
confidence: 99%