Tumour Necrosis Factor in B Chronic Lymphocytic Leukaemia

Hahn, Talia; Kusminsky, Gustavo; Bassous, Lucette; Barak, Yigal; Berrébi, Alain

doi:10.1111/j.1365-2141.1989.tb04275.x

Cited by 22 publications

(4 citation statements)

References 3 publications

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“…TNF‐α has been shown to be a growth factor for B‐CLL cells at an early but not at a late stage of the disease (30). In the present study, non‐progressive patients had the highest frequency of T cells spontaneously producing TNF‐α.…”

Section: Discussionmentioning

confidence: 99%

Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B‐CLL)

Rossmann

Lewin

Jeddi‐Tehrani

et al. 2002

European J of Haematology

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Analysis of cytokine production is a tool to functionally characterise T cells. In this study, spontaneous and polyclonal activation induced cytokine production in T cells were assessed by flow cytometry in patients with B-CLL. Patients with progressive disease had a significantly increased number of T cells spontaneously producing IL-2, IL-4 and GM-CSF as compared to healthy donors and patients with non-progressive CLL, which was not the case for TNF-alpha and IFN-gamma producing T cells. However, no difference in the frequency of T cells producing these cytokines was seen comparing patients with non-progressive disease to control donors. Polyclonal activation of B-CLL T cells in vitro induced an increased proportion of T cells producing these five cytokines in patients as well as in control donors, indicating that T cells in CLL patients might have a relatively well preserved functional capacity. However, the increase in GM-CSF, TNF-alpha and IL-4 producing T cells was more marked in CLL patients than in controls. Furthermore, following activation, a higher frequency of cytokine-producing T cells was noted in patients with progressive disease as compared to those with non-progressive disease. The augmented number of cytokine-producing T cells in CLL may indicate an up-regulated capability of T cells to secrete cytokines, especially in patients with progressive CLL. The increased production of the T cell derived cytokines GM-CSF, TNF-alpha, IL-4 and IL-2 is interesting, as these cytokines have previously been shown to support growth of B-CLL leukaemic cells in vitro and as T cells might specifically recognise the autologous leukaemic B cells in vivo. The findings may suggest a role for T cells in the pathogenesis of B-CLL.

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Section: Discussionmentioning

confidence: 99%

Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B‐CLL)

Rossmann

Lewin

Jeddi‐Tehrani

et al. 2002

European J of Haematology

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“…Serum levels of TNF-alpha were positively correlated with the number of risk factors and negatively correlated with blood fibrinogen levels, thus indicating that TNF correlates with the severity of meningococcaemia in children (Girardin et al, 1988 (Scuderi et al, 1986) and autoimmune disorders (Turner et al,87 (Hahn et al, 1989), and hairy cell leukaemia (Buck et al, 1988;Lindemann et al, 1989). In addition, TNF mRNA has been demonstrated on hairy cells stimulated in vitro with TNF (Cordingley et al, 1988a).…”

Section: Diseases In Which An Increase Of Tnf Has Been Foundmentioning

confidence: 99%

Tumour necrosis factor: a cytokine with multiple biological activities

Semenzato

1990

Br J Cancer

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“…High concentrations of soluble IL2 receptors, for example, have been detected in the serum of CLL patients, and IL-1 production by CLL cells has been documented (17)(18)(19)(20)(21)(22)(23). Other studies have suggested a role for TNF in supporting the proliferation of CLL cells (24,25). Another potential growth regulatory factor for CLL would be IL7 and/or IL-7 receptors.…”

mentioning

confidence: 99%

Genes for interleukin 7 are transcribed in leukemic cell subsets of individuals with chronic lymphocytic leukemia.

Frishman

Long

Knospe

et al. 1993

The Journal of Experimental Medicine

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SummaryRegulation of expression of interleukin 7 (IL-7) mRNA is aberrant in the leukemic subset of cells of chronic lymphocytic leukemia (CLL) patients. The entire coding sequence for IL-7 as well as an alternatively spliced IL-7 mRNA are transcribed in these leukemic cells. No IL-7 mRNA expression is detected in fresh peripheral blood mononuclear cells from normal individuals. Furthermore, the "normal" nonleukemic subsets of cells isolated from the same CLL patients also do not express IL-7 mRNA. The only subset of cells in which IL-7 mRNA is detected is the one that contains the leukemic cells themselves. The polymerase chain reaction was used to examine cytokine expression, and flow cytometry was used to purify the various subsets of peripheral blood mononuclear cells examined in these studies, as well as to examine IL-7 receptor expression. A proportion of the cells from the CLL patients express receptors that are capable of binding IL-7, whereas T cell-depleted normal cell preparations do not express receptors for IL-7 that are detectable with IL-7 fluorokines. The IL-7 receptor-bearing cells in CLL patients include a portion of leukemic cells and a fraction of the T cells, as well as some non-T, non-B cells. These findings suggest that IL-7 and IL-7 receptor expression in CLL may be relevant not only to growth regulation of the leukemic cells but to the immunological abnormalities that occur in the disease as well, possibly via the induction of inappropriate immune activity of IL-7 receptor-bearing cells.

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Tumour Necrosis Factor in B Chronic Lymphocytic Leukaemia

Cited by 22 publications

References 3 publications

Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B‐CLL)

Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B‐CLL)

Tumour necrosis factor: a cytokine with multiple biological activities

Genes for interleukin 7 are transcribed in leukemic cell subsets of individuals with chronic lymphocytic leukemia.

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