Tumour necrosis factor α G−308A polymorphism and risk for coronary artery disease

Wang, Xing Li; Oosterhof, Janine

doi:10.1042/cs19990318

Cited by 17 publications

(4 citation statements)

References 6 publications

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“…In addition, the tHcy level of the TNF- α–308GA genotype was higher compared to that of the TNF- α–308GG genotype. This result is in agreement with a report by Wang and Oosterhof [14]. The authors reported that the positive and significant association which exists between the homocysteine level and the TNF- α –308G→A polymorphism is consistent with TNF-α promoting oxidative stress in atherogenesis.…”

Section: Discussionsupporting

confidence: 83%

“…It also plays a significant role in obesity, insulin resistance, endothelial dysfunction, oxidative stress, and atherosclerosis [11]. Some studies have reported that the AA genotype significantly increases the transcriptional activity of the TNF- α –308 gene with respect to the GG genotype, and elevated plasma TNF-α protein and plasma total homocysteine (tHcy) levels [12,13,14]. …”

Section: Introductionmentioning

confidence: 99%

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Association between Tumor Necrosis Factor-Alpha (–308G→A and –238G→A) Polymorphisms and Homocysteine Levels in Patients with Ischemic Strokes and Silent Brain Infarctions

et al. 2010

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Background and Purpose: The aims of this study were to evaluate the role of tumor necrosis factor-α (TNF-α) polymorphisms in patients susceptible to ischemic stroke and silent brain infarction (SBI), and to determine the relationship between TNF-α polymorphisms and plasma total homocysteine (tHcy) levels. Methods: We studied 237 patients with ischemic stroke, 257 patients with SBIs, and 216 control subjects. For control subjects, we selected healthy individuals matched for gender and age from those individuals who came to our hospital for health examinations. The TNF-α–308G→A and –238G→A genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism method. Results: The frequency of the TNF-α–308G→A polymorphism was significantly different between the patients with ischemic stroke and the control group (GG vs. GA+AA; adjusted odds ratio, AOR, 0.50; 95% CI 0.255–0.989). By subgroup analysis, when tHcy levels were stratified into high (>10.80 µmol/l), moderate (8.21–10.80 µmol/l), and low levels (<8.21 µmol/l), the frequency of the TNF-α–308GA+AA genotype in the highest tertile group was higher than in the lowest tertile group (AOR 2.46; 95% CI 1.063–5.699). However, the relationship between SBI susceptibility and polymorphisms of TNF-αwas not established. The tHcy levels were significantly and inversely correlated with folate levels in the TNF-α–308GG and TNF-α–238GG genotypes in the ischemic stroke, SBI, and control groups (p< 0.05). Conclusions: Our results suggest that the TNF-α–308G→A polymorphism is responsible for susceptibility to ischemic stroke and is associated with high tHcy levels in Koreans.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Association between Tumor Necrosis Factor-Alpha (–308G→A and –238G→A) Polymorphisms and Homocysteine Levels in Patients with Ischemic Strokes and Silent Brain Infarctions

et al. 2010

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“…Our data confirm some previous studies that investigated Caucasian populations and failed to demonstrate that this locus could be a marker for greater risk of CAD. The same studies affirm that the allelic distribution is different according to the geographical origin of the study group (ranging from 24% to 12% for the rare allele) (25,30). However, in contrast to other published data (26,31), this may be due to different genetic and environmental risk factors or to different selection criteria of CAD patients.…”

Section: Discussionmentioning

confidence: 44%

–308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease

Ghazouani

Khalifa²,

Abboud³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…The research findings showed a positive and significant relationship between TNF-α gene polymorphism and levels of extracellular superoxide dismutase and homocysteine that are associated with clinical activity as oxidative stress in relation to atherogenesis. However, G-308 polymorphism is not directly associated with the occurrence and severity of atherosclerosis confirmed by angiography [21].…”

Section: Review Of Literaturementioning

confidence: 99%

The role of cytokine gene polymorphism in the development of acute myocardial infarction

Sid

2017

ZMJ

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The continuous growth of cardiovascular diseases is one of the important challenges facing the modern medicine. They are the primary cause of death both in developed countries and in Ukraine in particular.The aim of the study is to perform analysis of modern literary sources related to the role of cytokine gene polymorphism in the development of acute myocardial infarction.The basis for the search for candidate genes was study of individual characteristics and identifying genetic polymorphisms that increase the risk of triggering mechanisms of atherosclerotic lesions of the coronary vessels and the consequent acute myocardial infarction development. Cytokine genes feature a very high level of polymorphisms. The obtained results of the study are quite contradictory, in addition there is no consensus on their application. One of these candidate genes is the gene encoding interleukin-6 production. This is one of the proinflammatory cytokines, elevated levels of which are associated with the development and course of coronary heart disease, as well as with the processes of the atherosclerotic plaque destabilization. Polymorphic marker in interleukin-6 (-174-G/C) gene promoter is associated with IL-6 gene expression level and the level of Interleukin-6 in plasma, and can affect the course of ischemic heart disease. The tumor necrosis factor-α is a multifunctional proinflammatory cytokine which is produced mainly by monocytes and macrophages. Concentration of tumor necrosis factor-α in blood plasma is constantly increased in patients after acute myocardial infarction with an increased risk of recurrent coronary events. These data support the hypothesis that stable patients are at risk of constant inflammatory instability. Increased production of tumor necrosis factor-α is considered an important cause of destabilization of atherosclerotic plaques. The gene cluster of tumor necrosis factor-α is within the region of class III genes of highly polymorphic major histocompatibility complex, located on human chromosome 6 at the position 6p21.1-21.3. Another candidate gene encodes interleukin-10, being an anti-inflammatory cytokine is an inhibitor of inflammation located on chromosome 1 at the position 1q31-q32. The research identified a number of IL-10 gene polymorphisms at positions -592, -627, -1082.Conclusions. Analysis of the above literature allows us to make a conclusion that: first, the concentration of cytokines depends on the genetic characteristics of an individual; secondly, cytokine gene polymorphism may be of importance in regard to the course of coronary heart disease.Значення поліморфізму генів цитокінів у розвитку гострого інфаркту міокарда Є. В. СідьОдна з важливих проблем сучасної медицини -безперервне зростання серцево-судинних захворювань, що є провідною причиною смерті як у розвинених країнах світу, так і в Україні зокрема.Мета роботи -проаналізувати сучасні наукові літературні джерела щодо значення поліморфізму генів цитокінів у розвитку гострого інфаркту міокарда.Вивчення індивідуальних особливостей лю...

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Tumour necrosis factor α G−308A polymorphism and risk for coronary artery disease

Cited by 17 publications

References 6 publications

Association between Tumor Necrosis Factor-Alpha (–308G→A and –238G→A) Polymorphisms and Homocysteine Levels in Patients with Ischemic Strokes and Silent Brain Infarctions

Association between Tumor Necrosis Factor-Alpha (–308G→A and –238G→A) Polymorphisms and Homocysteine Levels in Patients with Ischemic Strokes and Silent Brain Infarctions

–308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease

The role of cytokine gene polymorphism in the development of acute myocardial infarction

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