Tumour necrosis factor-α promoter region polymorphisms affect the course of spontaneous HBsAg clearance

Kao, Pei‐Chi; Wu, Jia‐Feng; Ni, Yen‐Hsuan; Lin, Ying-Ting; Chen, Huey‐Ling; Hsu, Sandy Huey-Jen; Hsu, Hong–Yuan

doi:10.1111/j.1478-3231.2010.02340.x

Cited by 31 publications

(28 citation statements)

References 24 publications

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“…Our study also independently replicated the earlier findings of a Korean study and a Taiwanese study that showed an association of rs1800630 polymorphism with the outcome of HBV infection. 34,35 This independent replication strengthens the association of rs1800630 polymorphism with HBV outcome.…”

Section: Hla Polymorphism and Hbv Outcomesupporting

confidence: 60%

“…36 Recently, the TNF mutant A-allele has been shown to predict lower HBcAg-inducible TNF-a secretion and is also associated with chronicity. 35 We speculate that the transcriptional difference in rs1800630 promoter alleles influence pathogenesis and the outcome of HBV infection in the South Indian population. However, comprehensive functional studies are essential to unravel the underlying mechanism of rs1800630 polymorphism on the outcome of HBV infection.…”

Section: Hla Polymorphism and Hbv Outcomementioning

confidence: 87%

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Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population

et al. 2011

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The role of host genetic factors in the pathogenesis and outcome of hepatitis B virus (HBV) infection is not well known.We assessed the association of HLA and TNF (rs361525, rs1800629, rs1799724, rs1800630 and rs1799964) polymorphisms with HBV outcome in the South Indian population. Association of HLA polymorphism was analyzed in 90 individuals from each group, that is, spontaneous recovery (SR) and chronic-HBV (C-HBV) infection. The role of TNF polymorphisms was evaluated in 150 subjects with SR and 137 patients with C-HBV infection. After adjusting for age and sex, HLA-DRB1*07:01 was strongly associated with chronicity (corrected P-value (pc) o0.005, odds ratio (OR) 3.76, 95% confidence interval (CI) 1.84-7.68). The rs1800630 genotype was associated with HBV outcome in codominant (pco0.01, OR ¼ 1.99, 95% CI 1.30-3.05) and dominant (pco0.01, OR ¼ 2.28, 95% CI 1.35-3.84) analyzing models after adjusting for age and sex. Similarly, the rs1799964 genotype was associated with HBV outcome in codominant (pc ¼ 0.01, OR ¼ 1.57, 95% CI 1.09-2.27) and dominant (pco0.01, OR ¼ 2.21, 95% CI 1.27-3.83) analyzing models. Haplotype analysis (rs1799964/rs1800630/rs1799724/rs1800629/rs361525) revealed that the CACGG haplotype was strongly associated with C-HBV infection (P ¼ 0.0004). Our study suggests that inheritance of HLA and TNF polymorphisms might explain the outcome of HBV infection in the South Indian population.

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Section: Hla Polymorphism and Hbv Outcomesupporting

confidence: 60%

Section: Hla Polymorphism and Hbv Outcomementioning

confidence: 87%

Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population

et al. 2011

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“…Different HLA phenotypes and tumor necrosis factor-a (TNF-a) gene polymorphisms associated with recovery from HBV infection in different areas have been observed in Taiwan. (Wu et al 2004;Kao et al 2010) The different HLA phenotypes in different areas may be the reason for the higher rate of transition from viremia to recovery and carrier to recovery for the southern versus northern populations. Further incorporation of information on viral subtypes or HLA phenotypes and TNF-a gene polymorphisms into our formula of hazard function as a covariate may be a possible solution.…”

Section: Discussionmentioning

confidence: 99%

Stochastic model for hepatitis B virus infection through maternal (vertical) and environmental (horizontal) transmission with applications to basic reproductive number estimation and economic appraisal of preventive strategies

Hung

Wang

Yen

et al. 2013

Stoch Environ Res Risk Assess

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Elucidating the temporal natural history of Hepatitis B virus (HBV) infection provides not only useful information for assessing the spread of HBV infection but also a bedrock for economic appraisal of population-based preventive strategies (such as universal vaccination). HBV transmissions are transmitted through the maternal (vertical) route and environmental (horizontal) route. As the infection process from susceptible to active virus replication and finally to recovery state or to carrier state through both routes is not directly observable, mathematical models were therefore proposed to quantitatively elucidate the dynamic process of HBV infection with time. We began with a simple two-state model (from susceptible to infection) and further developed a five-state (including susceptible, latent phase, active viral replication, carrier, and recovery states) stochastic process to quantify the dynamics of HBV infection, making allowances for a mixed proportion of vertical and horizontal transmissions. The data used in the estimation, which were collected before implementation of a policy for universal HBV vaccination, were derived from several previous serum prevalence studies, including both low (northern) and high (southern) HBV prevalence areas, in Taiwan. The parameters obtained from stochastic models were converted to compute the basic reproductive number (R 0 ) in each study to indicate the extent of the spread of HBV infection. By linking the temporal natural history of HBV infection with the previously established Markov process for the sequelae of HBV infection (chronic hepatitis infection, liver cirrhosis, and hepatocelluar carcinoma), we developed a Markov cycle decision tree to evaluate the two populationbased preventive strategies related to vaccination and maternal lamivudine use with a cost-effectiveness analysis. In the five-state model, horizontal transmission was found to contribute more to HBV infection than vertical transmission in the northern area (59 vs. 41 %), whereas vertical transmission was more likely than horizontal transmission in the southern area (80 vs. 20 %). After considering the parameters of the two transmission routes, annual infection rate (person-years) for susceptible subjects was higher in the northern area (0.35) than the southern area (0.011). A similar finding was noted for annual rate of the transition from the latent period to active viral replications (1.12 in the northern area and 0.072 in the southern area). Annual rate of the conversion from active viral replication to the carrier state was higher in the southern area (0.184) than the northern area (0.119). Annual recovery rates were 0.014 in the northern area and 0.024 in the southern area for the carrier and 0.048 and 0.088 for transient viremia. The R 0 at age 30 using the parameters obtained from the five-state stochastic model was estimated as 4.88 in the northern and 7.03 in the southern area. Regarding the findings of economic appraisal, both preventive strategies were cost-saving, yielding the n...

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“…In particular, polymorphism of cytokines such as interleukin-6 (IL-6), Il-10, Il-18, IFN-gamma and tumour necrosis factoralpha (TNF) have been related to HBV clearance and/or to an unfavourable disease course of chronic HBV hepatitis [20][21][22][23][24]. Moreover, polymorphisms of genes coding for growth factors, such as those polymorphisms of transforming growth factor-alpha (TGF-a), have been suggested to have a role in the clearance of HBV and the occurrence of HCC [25].…”

Section: Discussionmentioning

confidence: 99%

Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection

Cmet¹,

Fabris

Fattovich

et al. 2012

Clinical and Experimental Immunology

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SummaryBecause epidermal growth factor (EGF) up-regulation is characteristic of the cirrhotic liver, we hypothesised that the EGF rs4444903 A > G functional polymorphism might be associated with a worse disease course in patients with chronic HBV infection. To verify this hypothesis, 170 HBV-positive patients (125 males) with a median age of 52 years were studied. Sixty-two of these patients were followed longitudinally for a median time of 21 years. Genotyping for the EGF rs4444903 A > G polymorphism was performed by the polymerase chain reaction-based restriction fragment length polymorphism assay. In the cross-sectional study, the EGF rs4444903 A > G polymorphism genotypic frequencies significantly differed between transplant patients (A/A = 20·4%, A/G = 52·3%, G/G = 27·3%) and HBsAg+ carriers (active and inactive: A/A = 35·7%, A/G = 47·6%, G/G = 16·7%, P = 0·036 for the linear trend). In the longitudinal study, the EGF rs4444903 A > G polymorphism was found to be an independent predictor of cirrhosis development (O.R. 7·73, 95% C.I. 1·21-49·5, P = 0·007). Three groups of patients were identified: A/A female homozygotes (n = 9), A/A male homozygotes (n = 13) and carriers of the G allele of either gender (n = 40). Cirrhosis did not occur among A/A females (n = 0/9), seldom occurred among A/A males (n = 2/13) and reached the highest frequency among G/* patients (n = 13/40, P = 0·026). In conclusion, the EGF rs4444903 A > G polymorphism appears to be associated with an unfavourable disease course of chronic HBV infection and cirrhosis development. This effect might be modulated, at least in part, by the gender of the patient.

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Tumour necrosis factor-α promoter region polymorphisms affect the course of spontaneous HBsAg clearance

Abstract: The A allele at the -863 locus of the promoter region of the TNF-α gene predicts lower HBcAg-inducible TNF-α secretion. It is also associated with chronicity of HBV infection.

Cited by 31 publications

References 24 publications

Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population

Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population

Stochastic model for hepatitis B virus infection through maternal (vertical) and environmental (horizontal) transmission with applications to basic reproductive number estimation and economic appraisal of preventive strategies

Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection

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Tumour necrosis factor-α promoter region polymorphisms affect the course of spontaneous HBsAg clearance

Abstract: The A allele at the -863 locus of the promoter region of the TNF-α gene predicts lower HBcAg-inducible TNF-α secretion. It is also associated with chronicity of HBV infection.

Cited by 31 publications

References 24 publications

Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population

Association of HLA and TNF polymorphisms with the outcome of HBV infection in the South Indian population

Stochastic model for hepatitis B virus infection through maternal (vertical) and environmental (horizontal) transmission with applications to basic reproductive number estimation and economic appraisal of preventive strategies

Carriage of the EGF rs4444903 A&gt;G functional polymorphism associates with disease progression in chronic HBV infection

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Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection