1994
DOI: 10.1177/030006059402200302
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Tumour Necrosis Factor-α Upregulates Transferrin Receptors in K 562 Cells

Abstract: The effects of tumour necrosis factor-alpha on transferrin receptor expression in a human chronic myelocytic leukaemia cell line, K 562 cells, were studied. Cytofluorometry studies showed that the numbers of transferrin receptors in exponentially growing K 562 cells were increased when the cells were incubated with tumour necrosis factor-alpha for 24 h. The induction of transferrin receptors by tumour necrosis factor-alpha may be mediated by a mechanism that is independent of growth since cell growth in treate… Show more

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Cited by 4 publications
(2 citation statements)
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“…Relatively little is known about the molecular mechanisms of IFN^y induction of class II genes. Studies on second messenger systems have implicated protein kinase C (PKC) (Fan et al, 1988;Mattila et al, 1989;Nezu et al, 1990), Ca2+-dependent processes (Koide et al, 1988; Celada and Maki,1991), cAMP (Frohman et al, 1988;Basta et al, 1989) and changes in intracellular pH as important second messengers in the IFN-y regulation of class II genes (Prpic et al, 1989). However, these observations vary between different cell lines.…”
Section: Introductionmentioning
confidence: 99%
“…Relatively little is known about the molecular mechanisms of IFN^y induction of class II genes. Studies on second messenger systems have implicated protein kinase C (PKC) (Fan et al, 1988;Mattila et al, 1989;Nezu et al, 1990), Ca2+-dependent processes (Koide et al, 1988; Celada and Maki,1991), cAMP (Frohman et al, 1988;Basta et al, 1989) and changes in intracellular pH as important second messengers in the IFN-y regulation of class II genes (Prpic et al, 1989). However, these observations vary between different cell lines.…”
Section: Introductionmentioning
confidence: 99%
“…Finally, in keeping with the mild microcytic hypochromic anemia and effect on reticulocyte hemoglobin parameters, observed in the peripheral blood, we also observed changes in the expression of transferrin receptors in the ProEB. Previously, it has been shown that TNF-a can regulate transferrin receptors on HepG2 hepatocytes, K562 leukemic cells and macrophages (45,46), and adversely affect iron metabolism (47). It has also been shown that the number and affinity of transferrin receptors on erythroblasts is lower in RA patients with ACD than in nonanemic RA patients and normal controls (48).…”
Section: Discussionmentioning
confidence: 99%