Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix

Cooper, R.; Carrington, Bernadette M; Loncaster, Juliette A; Todd, Susan M; Davidson, Susan E; Logue, John P; Luthra, Asha D; Jones, Andrew; Stratford, Ian J.; Hunter, Robin D; West, Catharine M L

doi:10.1016/s0167-8140(00)00259-0

Cited by 196 publications

(126 citation statements)

References 15 publications

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“…Alternatively, these regions have been shown to represent areas that may be more apt to undergo successful radiation therapyϪinduced reoxygenation. 32 Increased disease-free survival in patients with higher K trans , as observed in the present study, may be explained by the fact that a tumor with elevated blood flow and permeable vasculature has higher oxygenation levels, resulting in better access to chemotherapeutic drugs 28 and radiosensitivity. 33 On the other hand, lower K trans values indicate a heterogeneous blood supply and poor survival.…”

Section: Discussionsupporting

confidence: 51%

“…27 It is hypothesized that higher tumor blood flow will result in better oxygenation and drug delivery to the target site. 28 On the other hand, hypoxia (decreased blood flow) enhances chemoresistance and impedes delivery of therapeutic agents. 29 However, the relationship between HNSCC perfusion and hypoxia may be complex as recently described by several investigators 30,31 who used dynamic [ 18 F]luoromisonidazole PET to assess the perfusion of the primary tumor while simultaneously assessing tumor hypoxia through misonidazole binding.…”

Section: Discussionmentioning

confidence: 99%

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Prediction of Disease-Free Survival in Patients with Squamous Cell Carcinomas of the Head and Neck Using Dynamic Contrast-Enhanced MR Imaging

Chawla¹,

Kim²,

Loevner³

et al. 2011

AJNR Am J Neuroradiol

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Prediction of Disease-Free Survival in Patients with Squamous Cell Carcinomas of the Head and Neck Using Dynamic Contrast-Enhanced MR Imaging

Chawla¹,

Kim²,

Loevner³

et al. 2011

AJNR Am J Neuroradiol

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“…A more densely structured vasculature was found in the fast growing tumours and the increased vascular density correlated with estimates of plasma volume as assessed by MRI (van Dijke et al, 1996). However, in human studies these correlations have not been so strong, for instance, in a recent study of cervical carcinoma there was no clear relationship between MRI and IMD (Cooper et al, 2000). On the other hand a study in glioma, where VEGF has been more strongly implicated in the tumour's pathogenesis, did identify a relationship between MRI findings and IMD (Tynninen et al, 1999).…”

Section: Imd and Intra-tumoural Microvascular Characteristicsmentioning

confidence: 97%

Intra-tumoural microvessel density in human solid tumours

2002

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Over the last decade assessment of angiogenesis has emerged as a potentially useful biological prognostic and predictive factor in human solid tumours. With the development of highly specific endothelial markers that can be assessed in histological archival specimens, several quantitative studies have been performed in various solid tumours. The majority of published studies have shown a positive correlation between intra-tumoural microvessel density, a measure of tumour angiogenesis, and prognosis in solid tumours. A minority of studies have not demonstrated an association and this may be attributed to significant differences in the methodologies employed for sample selection, immunostaining techniques, vessel counting and statistical analysis, although a number of biological differences may account for the discrepancy. In this review we evaluate the quantification of angiogenesis by immunohistochemistry, the relationship between tumour vascularity and metastasis, and the clinicopathological studies correlating intra-tumoral microvessel density with prognosis and response to anti-cancer therapy. In view of the extensive nature of this retrospective body of data, comparative studies are needed to identify the optimum technique and endothelial antigens (activated or pan-endothelial antigens) but subsequently prospective studies that allocate treatment on the basis of microvessel density are required. British Journal of Cancer (2002) Angiogenesis is the process in which new blood vessels arise from existing ones. This is present physiologically in the adult during wound healing, the development of the ovarian follicle and corpus luteum and in the proliferating endometrium. Pathological angiogenesis is also a component of much diverse pathology ranging from diabetes and atherosclerosis to cancer, a disease that cannot progress without the formation of new blood vessels (Folkman, 1972).The measurement of angiogenesis is complicated by the fact that it is a dynamic process yet most studies to date have focused on the product of angiogenesis, the microvessel density, which was analysed at a particular point in time. Accepting this caveat there are extensive data in which the microvessel density correlates with metastasis and survival. Here, we discuss the relationship between angiogenesis and the intra-tumoural microvessel density (IMD), review the different techniques that have been used to measure IMD and then discuss the reasons why this relationship does not always hold. IMD AS A MEASURE OF TUMOUR ANGIOGENESISAs angiogenesis is a dynamic process, comparisons with snapshot views of the tumour, as are seen in biopsy analyses, are not straightforward. On the other hand the only approaches that are available in the clinic for the serial measurement of tumour angiogenesis involve molecular imaging strategies, such as contrastenhanced magnetic resonance imaging (MRI) and positron emission tomography (PET), that do not resolve data at the microscopic level. Thus it is important to assess the relationship between IMD and...

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“…In cervical carcinomas, significant positive correlations have been found between the signal enhancement and microvessel density [4] and median oxygen pressure (pO 2 ) [5,6], while a negative correlation has been found between the signal enhancement and the proportion of readings with pO 2 B5 mmHg (that is, the hypoxic fraction) [5]. Furthermore, a negative correlation has been found between the initial enhancement rate and the hypoxic fraction [5]. In breast cancers, the signal enhancement has been shown to correlate positively with microvessel density and tumor grade [7], while the initial enhancement rate correlated positively with microvessel density [8].…”

mentioning

confidence: 99%