Tumour phospholipid metabolism

High resolution magic angle spinning NMR spectroscopy for metabolic assessment of cancer presence and Gleason score in human prostate needle biopsies

“…This has not been reported previously for surgical prostate material, but correlations have been observed for metabolite ratios obtained from in vivo MR spectra and Gleason score [35,36]. Several studies have observed that abnormal choline metabolism is associated with the malignancy of cancer cells, e.g., [37,38]. No significant linear regression was found for the CC/C ratio with Gleason score which indicates that separate observation of choline and creatine peaks is desirable in grading of prostate cancer by MR spectroscopy.…”

Visualisation of bladder cancer using 11C-choline PET: first clinical experience

“…Choline is one of the components of phosphatidylcholine, an essential element of phospholipids in the cell membrane [6]. Malignant tumours may show a high proliferation and increased metabolism of cell membrane components, which will lead to an increased uptake of choline [7]. Recently, CHOL has been reported to be a potential radiopharmaceutical for the imaging of prostate and bladder cancer with PET [4,8].…”

In vivo detection of metabolic changes by 1 H-MRS in the DEN-induced hepatocellular carcinoma in wistar rat

“…A finding in human prostate cell and tumor cell derived from metastases defined that elevation of choline was attributable to an alteration in phospholipid metabolism (Ackerstaff et al 2001). The metabolism of tumour phospholipid is a complicated process including the choline cycle (Podo 1999). A recent in vivo 1 H-MRS study on human HCC with 3.0 T MR scanner showed that a significant statistical difference was achieved in the mean choline/lipid ratio between malignant and benign liver tumors (Kuo et al 2004).…”