Tumour promoters but not initiators deplete Langerhans cells from murine epidermis

Halliday, GM; MacCarrick, GR; Muller, HK

doi:10.1038/bjc.1987.198

Cited by 20 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,2 This ability to cause LC depletion could be a specific carcinogenrelated phenomenon, however, evidence exists that the complete carcinogen DMBA can induce contact sensitivity 3 as well as increasing the rate of LC migration. 4,5 Likewise, the tumour promoter, TPA is able to induce contact sensitivity 6 as well as increasing the rate of LC migration.…”

Section: Introductionmentioning

confidence: 99%

Chemical carcinogens and antigens induce immune suppression via Langerhans' cell depletion

Woods

Ragg

et al. 1996

Immunology

View full text Add to dashboard Cite

SUMMARYThe ability of the chemical carcinogen dimethylbenz(a)anthracene (DMBA) to deplete Langerhans' cells (LC) from murine skin is crucial to the development of antigen-specific suppression. This depletion is a consequence of the LC recognizing the DMBA as antigenic and migrating to the draining lymph nodes to attempt to elicit T-cell activation. This depletion also occurred following exposure to high doses of the contact sensitizers 2,4-dinitrofluorobenzene (DNFB), 2,4,6-trinitrochlorobenzene (TNCB) and fluorescein isothiocyanate (FITC). However, LC depletion was not significant at lower doses, even though these doses were sufficient to induce strong contact sensitivity responses. Application of the contact sensitizer, DNFB, through skin depleted of LC (by pretreatment with either the carcinogen DMBA or the antigen TNCB) failed to induce contact sensitivity. This immune nonresponsiveness was antigen specific, and could be transferred by spleen cells to naive mice, which were unable to respond to DNFB. Mouse skin treated with doses of TNCB, that did not cause LC depletion but still induced a normal contact hypersensitivity, retained its ability to initiate a normal immune response to DNFB. Together these findings demonstrate that carcinogens share some properties with antigens as they both cause LC depletion and interact with the immune system. Furthermore, it is this LC depletion, rather than carcinogen treatment, that is a critical factor which leaves the skin immunologically compromised and favours the induction of antigen-specific suppression.

show abstract

Section: Introductionmentioning

confidence: 99%

Chemical carcinogens and antigens induce immune suppression via Langerhans' cell depletion

Woods

Ragg

et al. 1996

Immunology

View full text Add to dashboard Cite

show abstract

“…35 DMBA, a powerful carcinogen, and the tumor promoter TPA induce immune suppression via Langerhans' cell depletion-an important factor underlying the pathogenesis of skin cancer. 39,40 TPA is known as a protein kinase C (PKC) activator increasing the expression of several oncogenes. 41 Activation of PKC stimulates NADPH oxidase to produce ROS 42 which may act as a signaling molecule.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy with 5‐aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin

Kwitniewski

Jankowski

Jaskiewicz

et al. 2009

Intl Journal of Cancer

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is used to treat malignant and nonmalignant diseases. It is also used for cosmetological skin treatment. PDT is generally considered to have a low risk of carcinogenicity. However, instances of nonmalignant human tumors turning malignant have been linked to PDT. In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg) 2 , PP(Ser) 2 Arg 2 , PP(Ala) 2 Arg 2 , all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-Otetradecanoyl-phorbol-13-acetate (TPA). Of these drugs, ALA and PP(Arg) 2 were found the most efficient. PDT reduced the number of papillomas, but with increasing effectiveness of the drugs, the risk of malignant transformation of the papillomas into squamous cell carcinomas increased. The underlying mechanisms are not clear and further investigations are needed. ' 2009 UICC

show abstract

Depletion of Langerhans Cells Following Carcinogen Treatment is Partly Due to Antigenicity

Woods

1993

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Tumour promoters but not initiators deplete Langerhans cells from murine epidermis

Cited by 20 publications

References 16 publications

Chemical carcinogens and antigens induce immune suppression via Langerhans' cell depletion

Chemical carcinogens and antigens induce immune suppression via Langerhans' cell depletion

Photodynamic therapy with 5‐aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin

Depletion of Langerhans Cells Following Carcinogen Treatment is Partly Due to Antigenicity

Contact Info

Product

Resources

About