Tumour-released exosomes and their implications in cancer immunity

Iero, Manuela; Valenti, Roberta; Huber, Veronica; Filipazzi, Paola; Parmiani, Giorgio; Fais, Stefano; Rivoltini, Licia

doi:10.1038/sj.cdd.4402237

Cited by 446 publications

(353 citation statements)

References 72 publications

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“…Induction of TNF-a therefore signifies simultaneous upregulation of angiogenic and immunosuppressive activities by native melanoma exosomes in the lymph node microenvironment. This supports our previous work showing simultaneous induction of angiogenesis and immunosuppressive factors (GM-CSF and TNF-a) by melanoma exosomes (15) and is consistent with other in vitro reports showing melanoma microvesicle mediated "counterattack" of antitumor T-cells (8) and induction of MDSCs (11,46) which suppress antitumor T-cell function (45).…”

Section: G-α13supporting

confidence: 80%

“…This is exemplified by the recruitment of the majority of melanoma cells to the left PO sentinel node where they are buffered by an even greater number of melanoma exosomes. Given our data and the numerous reports of tumor exosome-mediated immune suppression (11)(12)(13), it seems logical that tumor exosomes would have a role in conditioning sentinel lymph nodes for the controlled spread of metastasis whereby routes of communication between primary and metastatic tumors can be efficiently maintained.…”

Section: G-α13mentioning

confidence: 96%

“…Exosomes are naturally occurring biological nanovesicles ($30-100 nm) that are formed by the inward budding of multivesicular bodies (MVB), as a component of the endocytic pathway (7)(8)(9)(10)(11). They are generated constitutively and released into the tumor microenvironment and circulation via fusion of MVBs with the tumor cell plasma membrane.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

Hood¹,

San²,

Wickline³

2011

Cancer Research

887

747

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Exosomes are naturally occurring biological nanovesicles utilized by tumors to communicate signals to local and remote cells and tissues. Melanoma exosomes can incite a proangiogenic signaling program capable of remodeling tissue matrices. In this study, we show exosome-mediated conditioning of lymph nodes and define microanatomic responses that license metastasis of melanoma cells. Homing of melanoma exosomes to sentinel lymph nodes imposes synchronized molecular signals that effect melanoma cell recruitment, extracellular matrix deposition, and vascular proliferation in the lymph nodes. Our findings highlight the pathophysiologic role and mechanisms of an exosome-mediated process of microanatomic niche preparation that facilitates lymphatic metastasis by cancer cells. Cancer Res; 71(11); 3792-801. Ó2011 AACR.

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Section: G-α13supporting

confidence: 80%

Section: G-α13mentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

Hood¹,

San²,

Wickline³

2011

Cancer Research

887

747

View full text Add to dashboard Cite

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“…23 Another strongly anticipated use of the BMC is the detection of circulating microvesicles (100 nm structures shed from tumor cells) which exist in low concentration in blood but have very distinct molecular signatures. 24 The BMC can also be used in pharmaceuticals where characterization of preformulations can be made cheaper by consuming smaller volumes of drugs. 25 …”

Section: Introductionmentioning

confidence: 99%

Nanomechanical identification of liquid reagents in a microfluidic channel

et al. 2014

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Integration of promising technologies that can enhance sensitivity, selectivity, and throughput into micro total analysis systems (μTAS) are important in making them useful in precise screening of reaction byproducts in analytical chemistry, cellular biology and pharmaceutical industries. But unfortunately so far a method to precisely determine molecular signatures of reagents is missing in μTAS. We have developed a technique whereby molecular signatures of 50 pL of liquid reagents confined within a bimetallic microchannel cantilever can be obtained. This is achieved using wavelength dependent mechanical bending of the cantilever under infrared (IR) radiation. This technique also allows simultaneous physical characterization of the liquid reagent using variations in resonance frequency. It is useful in lab-on-a-chip devices and has a myriad of applications in drug screening, bioreactor monitoring, and petrochemical analysis.

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“…Is it possible to improve anticancer therapies by neutralizing the tumor-dependent immunosuppression? 9 We are confident that the interested reader will find (partial) answers to these important questions in the accompanying special issue of Cell Death & Differentiation. More importantly, we anticipate that the full comprehension of this topic -and its translation into human medicine -will eventually improve the clinical management of cancer.…”

mentioning

confidence: 99%