'Tumour volume' as a predictor of survival after resection of non-small-cell lung cancer (NSCLC)

Jefferson, Miles; Pendleton, Neil; Faragher, E. B.; Dixon, G. R.; Myskow, M.W.; Horan, Michael A.

doi:10.1038/bjc.1996.381

Cited by 24 publications

(12 citation statements)

References 19 publications

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“…Despite the advances in diagnostic techniques for the early detection of lung cancer and the significant improvement in surgical procedures, the survival rate of lung cancer patients is poor even in the early stages of cancer as compared to the other malignant neoplasms. From a clinical point of view, one of the most troublesome impediments for treatment of lung cancer is the metastasis to mediastinal lymph nodes (n = 2 and n = 3 lung cancer) from the primary lesion (Jefferson et al, 1996). If metastases were inhibited by the present and/or new therapies, the prognosis of patients with lung cancer would improve.…”

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Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice

et al. 1999

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Lung neoplasm, in place of gastric cancer, is the major cause of cancer mortality in Japan as well as in the USA (Travis et al, 1995). Despite the advances in diagnostic techniques for the early detection of lung cancer and the significant improvement in surgical procedures, the survival rate of lung cancer patients is poor even in the early stages of cancer as compared to the other malignant neoplasms. From a clinical point of view, one of the most troublesome impediments for treatment of lung cancer is the metastasis to mediastinal lymph nodes (n = 2 and n = 3 lung cancer) from the primary lesion (Jefferson et al, 1996). If metastases were inhibited by the present and/or new therapies, the prognosis of patients with lung cancer would improve. According to new TNM revisions (Mountain, 1997), it is difficult to say if the 5-year survival rate of n ³ 2 in lung cancer patients is an improvement, although a standard operative technique has been established to resect mediastinal lymph nodes (Vansteenkiste et al, 1997), except for aortic lymph node metastasis (Nakanishi et al, 1997). Therefore, biological approaches and studies, such as interference with lymph node metastasis or management of downstaging to the patients with lymph node metastasis, combined with surgery are required for lung cancer therapy. To do this, suitable animal models that conform to the clinical features are also necessary to search for novel therapies of lung cancer and to evaluate the efficacy of new drugs. However, there are few models for the formation of a solitary pulmonary nodule by orthotopic implantation of lung cancer cells and subsequent lymph node metastasis. In the present study, we attempted to establish a simple model for a solitary lung tumour and its lymph node metastasis by intrapulmonary implantation of Lewis lung carcinoma (LLC) cells in mice. MATERIAL AND METHODS AnimalsSpecific pathogen-free female C57BL/6 mice at 6 weeks old, were purchased from Japan SLC, Inc, Hamamatsu, Japan. They were maintained in the Laboratory for Animal Experiments, Research Institute for Wakan-Yaku Toyama Medical and Pharmaceutical University, under laminar air-flow conditions. All animals had free access to standard laboratory mouse food and water ad libitum. Housing was temperature controlled with a 12-h light and dark cycle. This study was conducted in accordance with the standards established by the Guidelines for the Care and Use of Laboratory Animals of Toyama Medical and Pharmaceutical University. Summary This study is designed to establish a pulmonary tumour model to investigate the biology and therapy of lung cancer in mice. Current methods for forming a solitary intrapulmonary nodule and subsequent metastasis to mediastinal lymph nodes are not well defined. Lewis lung carcinoma (LLC) cell suspensions were orthotopically introduced into the lung parenchyma of C57/BL6 mice via a limited skin incision without thoracotomy followed by direct puncture through the intercostal space. The implantation process was performed within approximately ...

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Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice

et al. 1999

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“…[11,13] Similarly, the present study demonstrated that increased tumor volume had a negative effect on survival. The patients with a tumor volume below the calculated cut-off value had a longer survival.…”

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confidence: 63%

“…Review of the literature reveals that there is a similar study conducted by Jefferson et al, [11] investigating the effect of volume on survival. The aforementioned study also calculated the tumor volume by taking the maximum lengths of all three dimensions of the tumor in the postoperative pathological piece.…”

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Does tumor volume affect survival in patients with operated early-stage non-small-cell lung cancer?

Kaya¹

2017

Turk Gogus Kalp Dama

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ÖZAmaç: Bu çalışmada erken evre ameliyat edilen küçük hücreli dışı akciğer kanserli hastalarda tümör hacminin sağkalımı etkileyip etkilemediği araştırıldı. ) 2 olasılık oranı (OR) ile sağkalımı artırmakla birlikte, bu değer istatistiksel olarak anlamlı idi (p= 0.022). T faktörüne göre eşik değer 4.5 cm olup, OR=1.7 idi; ancak, sağkalım ile arasında anlamlı bir ilişki gözlenmedi (p= 0.058). Ça lış ma pla nı:So nuç: Bu çalışmada en büyük tümör çapı ve sağkalım arasındaki bilinen ilişkinin aksine, tümör hacmi ile sağkalım arasında daha yakın bir ilişki saptandı. Çalışma bulgularımıza göre, akciğer kanseri evrelemesinde tümör çapı ile beraber tümör hacminin hesaplanması ve göz önünde bulundurulması önerilmektedir.Anah tarsöz cük ler:Akciğer kanseri; prognoz; evreleme; tümör hacmi. ABSTRACTBackground: This study aims to investigate whether tumor volume affects survival in patients with operated early-stage nonsmall-cell lung cancer.

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“…We were interested to read the paper on survival after resection of non-small-cell lung cancer (NSCLC) in relation to 'tumour volume' by Jefferson et al (1996).…”

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'Tumour volume'

Clelland¹

1997

Br J Cancer

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We were interested to read the paper on survival after resection of non-small-cell lung cancer (NSCLC) in relation to 'tumour volume' by Jefferson et al (1996).By multiplying together the three dimensions of each tumour, the authors have assumed that the carcinomas are box shaped. The accuracy of this assumption was not validated. In a study of 54 resected lung cancers (Binks et al, 1996), we found that the most appropriate measures of tumour volume were to assume that the tumours were ellipsoidal or boxes. These measurements compared well with our gold standard methods (R = 0.887 and R = 0.910 respectively) of sequential 1-mm or 1-cm slices, for which the tumour area was measured and the volume derived from the sum of the areas. In contrast, measurement of the maximum dimension and assuming a spherical shape grossly overestimated the volume of some tumours (R = 0.632).Although we expected ellipsoidal measurements to be more accurate than boxes, this was not the case. We support the authors statement that tumour volume is a useful piece of information that is easily collected, but three dimensions should always be measured for solid tumours. Yours faithfully CA Clelland, Nottingham City Hospital, NHS Trust Hucknall Road, Nottingham, NG5 JPB UK

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'Tumour volume' as a predictor of survival after resection of non-small-cell lung cancer (NSCLC)

Cited by 24 publications

References 19 publications

Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice

Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice

Does tumor volume affect survival in patients with operated early-stage non-small-cell lung cancer?

'Tumour volume'

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