Tumoural calcinosis of the cervical spine: case report, pathogenesis and differential diagnosis

Qadri, Shagufta; Choksey, M. S.; Shad, Abdur R.

doi:10.1080/02688690500145811

Cited by 9 publications

(13 citation statements)

References 18 publications

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“…Etiology, pathogenesis and classification. [2,[4][5][6]10,16,17,23,26,28,30,33]. However, some authors point out that the term tumoral calcinosis signifies primary pathology [1,6,12,26], whereas lesions secondary to pre-existing disease should be named tumoral calcinosis-like lesions [18].…”

Section: Discussionmentioning

confidence: 99%

“…Some researchers explain the development of TC in the proximity of joints, based on mechanical conception. They argue that the periarticular forces and repetitive mechanical stimulation may initiate localized disturbance of the calcium metabolism, which in turn provoke calcium phosphate depositions in soft tissue [1,4,6,8,10,14,22,28]. Regarding the spinal TC, the causative role of facet joint degeneration, hypermobility and local inflammation was suggested [3,17,30].…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the spinal TC, the causative role of facet joint degeneration, hypermobility and local inflammation was suggested [3,17,30]. In the majority of cases the calcified masses were observed around posterior vertebral elements [11][12][13][14]18,21,22,24,25,27,30,31,33] and in the spinal canal [2,11,14,15,17,19,21,22,24,25,27,28,36]. Rarely found inside the dura mater of the spine [5,23,29,32].…”

Section: Discussionmentioning

confidence: 99%

“…Rarely found inside the dura mater of the spine [5,23,29,32]. Clinical manifestation of spinal TC entailed: palpable tender paraspinal mass [18,20,26,31], axial pain in affected spinal segment [2,3,11,13,15,18-23, 27,30], limited cervical or lumbar range of motion [9,11,13,15,20], tetraparesis [14,22,28,33], paraparesis [2,3,17,30,32,36], lower extremity spasticity [5] and radiculopathy in the distribution of the compressed nerve roots [3,9,13,16,18,29,30,36]. Spinal deformity, such as torticollis or rapidly progressing scoliosis, was the main symptom in case of children [19,24,25].…”

Section: Discussionmentioning

confidence: 99%

“…The masses most frequently presented low signal intensity on both T1 and T2-weighted MR images [2,3,11,15,16,[18][19][20][21]23,25,27,29,30]. Mixed signal intensity was also observed [3,5,13,17,22,28,32,36]. Gadolinium enhanced intratumoral septa or tumoral margins in a fraction of cases [5,17,20,23,28,30,32].…”

Section: Discussionmentioning

confidence: 99%

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Tumoral calcinosis of the cervical spine in a dialysis patient. Case report and review of the literature

Zapałowicz

Stasiów

Ciupińska-Kajor

et al. 2017

Neurologia i Neurochirurgia Polska

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The authors present a case of tumoral calcinosis (TC) in a patient with chronic renal insufficiency. The clinical course, imaging features and microscopic findings are detailed. A 60-year-old woman with a 4-year history of hemodialysis presented with a painful mass in the right posterior cervical triangle. The neuroimaging revealed polycystic mass bulging from the C3-C5 facet joints and lamina on the right. The majority of cystic mass was excised and microscopic features of the specimen were consistent with TC. Tumoral calcinosis is a rare disease characterized by calcium salt deposits in periarticular soft tissue, which enlarge to form tumor-like cystic masses containing chalky calcareous material. TC is typically seen around large joints but rarely in the spine. Review of past publications provided six cases of TC involving the spine in dialyzed patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Tumoral calcinosis of the cervical spine in a dialysis patient. Case report and review of the literature

Zapałowicz

Stasiów

Ciupińska-Kajor

et al. 2017

Neurologia i Neurochirurgia Polska

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Dystrophic calcinosis with both a huge calcified mass in the cervical spine and calcification in the chest wall in a patient with rheumatoid overlap syndrome

Nakamura¹,

Hirakawa

Takaoka³

et al. 2014

Clin Rheumatol

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Dystrophic calcinosis in soft tissue occurs in damaged or devitalized tissues in the presence of normal calcium and phosphorous metabolism. It is often noted in subcutaneous tissues in patients with collagen vascular diseases and may involve a relatively localized area or be widespread. A 74-year-old Japanese woman with an overlap of rheumatoid arthritis, Sjögren's syndrome, and systemic sclerosis developed a huge tumor-like mass at the atlanto-axial vertebral joint region that caused severe cervical pain and difficulty in activities of daily living. She also had subcutaneous dystrophic calcification in the soft tissue of the chest wall. Calcinosis associated with systemic sclerosis is a well-recognized phenomenon, but a destructive paraspinal tumor in the cervical spine associated with overlap syndrome is extremely unique. Because calcinosis in spinal locations can be complicated by neurological involvement, patients with progressive symptoms may require surgical intervention. Surgical resection and biological therapy improved this patient's life and activities of daily living. Calcinosis is common in the conditions reviewed here, and different agents have been used for treatment. However, calcinosis management is poorly organized and lacks an accepted classification, systematic studies, and clinical therapeutic trials. The association of calcinosis and collagen vascular diseases is clinically and etiologically important. Although a combination of calcinosis and rheumatoid overlap syndrome is rare, various collagen vascular diseases may occur simultaneously. A perceptive diagnostic approach toward these diseases is critical, and early diagnosis and treatment are needed to prevent dystrophic calcinosis.

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Spinal calcifying pseudoneoplasm of the neuraxis (CAPNON) associated with facet joint pathologies: CAPNON diagnostic and pathogenic insights

Fareez,

Yahya,

Fong

et al. 2024

Human Pathology

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Tumoural calcinosis of the cervical spine: case report, pathogenesis and differential diagnosis

Cited by 9 publications

References 18 publications

Tumoral calcinosis of the cervical spine in a dialysis patient. Case report and review of the literature

Tumoral calcinosis of the cervical spine in a dialysis patient. Case report and review of the literature

Dystrophic calcinosis with both a huge calcified mass in the cervical spine and calcification in the chest wall in a patient with rheumatoid overlap syndrome

Spinal calcifying pseudoneoplasm of the neuraxis (CAPNON) associated with facet joint pathologies: CAPNON diagnostic and pathogenic insights

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