Tumoural denervation of the nigrostriatal pathway

Abstract

A 22-year-old woman, diagnosed 7 years ago with low-grade astrocytoma in the left mesencephalon, presented with an initial clinical picture of severe intention and resting tremor in the right limbs.The tumour was treated with radiation therapy, and currently no signs of progression appear in the radiological control examinations, although the symptoms still persist and prevent the patient from carrying out daily activities.The last radiological exam (A) showed a calcified tumour in the left thalamus and mesencephalon, without structural affectation in the basal ganglia, so a functional assessment of the nigrostriatal system through a combined study of presynaptic dopamine transporters and postsynaptic D 2 receptors was performed [1].The study performed with