Tumours in End-Stage Kidney

Hora, Milan; Hes, Ondřej; Reischig, Tomáš; Ürge, Tomáš; Klečka, Jiří; Ferda, Jiří; Michal, Michael; Eret, Viktor

doi:10.1016/j.transproceed.2008.08.135

Cited by 51 publications

(28 citation statements)

References 23 publications

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“…[87][88][89][90][91][92][93][94] In up to 70% of cases more than one tumor was present in a single kidney. 95 In a detailed study of 66 tumor-bearing kidneys from patients with end-stage renal disease, a wide spectrum of renal neoplasia was noted. 96 In total 261 tumors were examined with 54.5% of kidneys containing 41 tumor in each kidney ranging from 0.6 to 8.5 cm (mean 3.0 cm, median 2.6 cm).…”

Section: Carcinoma Associated With End-stage Renal Diseasementioning

confidence: 99%

Uncommon and recently described renal carcinomas

2009

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Major consensus conferences held over a decade ago laid the foundations for the current (2004) WHO classification of renal carcinoma. Clear cell, papillary and chromophobe carcinomas account for 85-90% carcinomas seen in routine practice. The remaining 10-15% of carcinomas consist of rare sporadic and hereditary tumors, some of which had been long recognized, but many of which only emerged as distinct entities in the decade leading up to the WHO publication. Collecting-duct carcinoma is a rare, often lethal form of carcinoma. Medullary carcinoma associated with sickle cell trait, has emerged as a distinctive tumor showing some overlapping features with upper tract urothelial carcinoma. Mucinous tubular and spindle-cell carcinoma and tubulocystic carcinoma were earlier considered as patterns of low-grade collecting-duct carcinoma, but are now recognized as separate tumor entities. Carcinomas associated with somatic translocations of TFE3 and TFEB comprise a significant proportion of pediatric renal carcinomas. Oncocytoid renal carcinomas in neuroblastoma survivors was recognized as a unique tumor category in the WHO classification. Renal carcinoma associated with end-stage renal disease is now recognized as having distinct morphological patterns and behavior. In addition there is a group of rare recently described carcinomas, including clear cell papillary carcinoma, oncocytic papillary renal cell carcinoma, follicular renal carcinoma and leiomyomatous renal cell carcinoma. It behooves the surgical pathologist to not only be capable of diagnosing the common forms of renal cancer, but also to be aware of the rare types of renal carcinoma, many of which have emerged in recent years.

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Section: Carcinoma Associated With End-stage Renal Diseasementioning

confidence: 99%

Uncommon and recently described renal carcinomas

2009

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“…CEUS is minimally invasive, easy to use, cheap, and allows for reproducible measurements without adverse effects [14]. Papillary RCC seems to be the most predominant histological subtype in acquired cystic kidney disease-associated RCC in native kidneys (up to 70% compared to 10-15% in sporadic RCC) [15] but occurs also in transplanted kidneys [5,8,11], with unique described features on contrast-enhanced imaging as following: papillary RCC has less intratumoral vascularity and enhances less than clear-cell RCC in all phases of contrast-enhanced imaging [16]. This finding is in line with the present case confirming the diagnosis by CEUS, where the papillary tumor was enhanced after a bolus injection of contrast agent, but remained hypoechoic compared the surrounding renal parenchyma.…”

Section: Discussionmentioning

confidence: 99%

De novo Renal Cell Carcinoma in a Kidney Allograft with Focus on Contrast-Enhanced Ultrasound

Pichler¹,

Heidegger²,

Bösmüller³

et al. 2014

Urol Int

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The development of de novo renal cell carcinoma (RCC) in a transplanted kidney is a rare condition. Currently, this is the second case report of a 41-year-old man in whom carcinoma of a renal allograft was detected by contrast-enhanced ultrasound (CEUS). An abdominal CT scan was not conclusive enough to differentiate between septal enhancement of a cyst and a low vascularized tumor. CEUS confirmed a solid, homogeneously enhancing but hypoechoic and hypovascular lesion compared to the surrounding kidney parenchyma without septal enhancement. Therefore, the patient underwent nephron-sparing surgery (NSS), affirming papillary RCC type 2. Graft function remained unchanged postoperatively; 12 months after NSS, no local recurrence or distant metastasis was described. CEUS seems to be a minimally invasive and efficient imaging option if other diagnostic tools cannot clearly exclude RCC, with the advantage of wide-ranging use, especially in cases of impaired renal function.

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“…After surgery, follow-ups were conducted with patients every 3-6 months. Hemodialysis patients were not included in this study because patients on dialysis were at great risk of developing RCC, due to end-stage renal disease, than healthy controls of equivalent age [13][14][15].…”

Section: Methodsmentioning

confidence: 99%

Pathological Grade and Gender are Predictors of Small Renal Cell Carcinoma Growth

Sugimoto¹

2014

J Integr Oncol

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Objective: This study was undertaken to investigate the clinicopathological factors that influence the growth of a small renal mass (SRM) in patients subjected to a delayed surgery intervention. Methods:We reviewed the clinical records of 37 patients with SRM 4 cm at diagnosis, who underwent delayed surgical intervention during surveillance from January 2000 to December 2013. Radiographic evaluation using computed tomography (CT) scan, magnetic resonance imaging (MRI) were performed at least every 6 months and the tumor size was determined at least twice.Results: Histopathological analysis revealed that in 35 of the 37 patients the tumor was malignant in stage pT1aN0M0. There were 28 clear cell carcinomas and 7 non clear cell carcinomas. There was a significant difference in the time to tumor doubling (TTD) among clear cell carcinomas (p=0.033). There was also a significant difference in the tumor growth rate (mm/year) of clear cell carcinomas between male and female patients (p=0.028). Conclusion:The growth rate of small renal mass was slow in the majority of our patients. Pathological grade and gender significantly influenced the growth of clear cell carcinomas.

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Tumours in End-Stage Kidney

Cited by 51 publications

References 23 publications

Uncommon and recently described renal carcinomas

Uncommon and recently described renal carcinomas

De novo Renal Cell Carcinoma in a Kidney Allograft with Focus on Contrast-Enhanced Ultrasound

Pathological Grade and Gender are Predictors of Small Renal Cell Carcinoma Growth

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