Tumours of the fifth cranial nerve

Benedittis, Giuseppe De; Bernasconi, V.; Ettorre, G

doi:10.1007/bf01401542

Cited by 73 publications

(31 citation statements)

References 22 publications

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“…While some degree of leptomeningeal melanosis occurs in up to 85% of the population, heterotrophic melanin detected in the dura is rare 11 . Reports of primary dural melanoma are rare [12][13][14][15][16][17][18] and tumors of the fifth nerve in general are extremely rare and comprise 0.2 % of all primary and secondary intra-cranial neoplasms 4 . Melanomas of the fifth nerve are even rarer 5,6 .…”

Section: Discussionmentioning

confidence: 99%

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Primary melanoma of Meckel's cave: case report

Falavigna

Borba²,

Ferraz

et al. 2004

Arq. Neuro-Psiquiatr.

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-We present a case of trigeminal neuralgia with cranial normal magnetic resonance image (MRI) and computed tomography.The pain was not relieved by carbamazepine and microvascular decompression surgery was done.After two months the pain was similar to the condition before surgery. At this time, MRI showed an expansive lesion in Meckel's cave that was treated with radical resection by extra-dural approach. The pathologic examination revealed a primary melanoma. The follow-up after six months did not show abnormalities.KEY WORDS: primary melanoma, central nervous system, Meckel's cave, carbamazepine.Melanoma primário do cavo de Meckel: relato de caso RESUMO -Apresentamos um caso de neuralgia do trigêmeo com investigação radiológica de ressonância magnética (RM) e tomografia computadorizada apresentando resultado normal.A dor não apresentou alívio com carbamazepina, sendo indicado descompressão microvascular do trigêmio. Passados dois meses, o paciente queixava-se de dor com intensidade similar à do pré-operatório. Nova RM mostrou lesão expansiva no cavo de Meckel, a qual foi tratada cirurgicamente por abordagem extra-dural. O exame anatomopatológico foi compatível com melanoma primário. O seguimento radiológico, após seis meses da cirurgia, não apresentou anormalidades.PALAVRAS-CHAVE: melanoma primário, sistema nervoso central, cavo de Meckel, carbamazepina.The central nervous system (CNS) is host to a wide variety of melanocytic neoplasms including the common metastatic malignant melanoma and the relatively benign, as well as overtly malignant, primary neoplasms of leptomeningeal melanocyte 1 . Metastases of malignant melanomas in the CNS are fairly common; their incidence is approximately 5-10% of all tumors metastatizing to the CNS. In contrast, primary melanomas of the CNS are a rare occurrence 2,3 .Trigeminal neuralgia is often the first complaint for a tumor of the Gasserian ganglion. Tumors of the fifth nerve in general are extremely rare and comprise 0.2 % of all primary and secondary intracranial neoplasms 4 . Melanomas of the fifth nerve are even rarer 5,6 . We report a case of trigeminal neuralgia that was not relieved by carbamazepine and microvascular decompression. The expansive lesion was detected in Meckel´s cave only after a second magnetic resonance image (MRI) and the histopathological examination showed a primary melanoma. CASEA 55-year old man, smoker, complains of right trigeminal neuralgia that began 4 months ago. The neurological examination was normal and treatment was instituted with carbamazepine 600mg a day.The neurological investigation was performed by cranial MRI and computed tomography (CT).After 30 days the patient returned without relief of the facial pain and with a normal neuroradiological examination (Fig. 1A). Microvascular decompression was indicated with displacement of the vessel impinging on nerve. The pain relief was temporary. After 60 days the pain was similar to the conditions before surgery and carbamazepine dose was increased to 1000 mg a day CT showed only t...

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Section: Discussionmentioning

confidence: 99%

“…In contrast, primary melanomas of the CNS are a rare occurrence 2,3 .Trigeminal neuralgia is often the first complaint for a tumor of the Gasserian ganglion. Tumors of the fifth nerve in general are extremely rare and comprise 0.2 % of all primary and secondary intracranial neoplasms 4 . Melanomas of the fifth nerve are even rarer 5,6 .…”

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confidence: 99%

Primary melanoma of Meckel's cave: case report

Falavigna

Borba²,

Ferraz

et al. 2004

Arq. Neuro-Psiquiatr.

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“…[11][12][13] Combined data from the literature show that the median age at diagnosis is 37 years and the tumor is slightly more common in women (59%).…”

Section: Discussionmentioning

confidence: 99%

Sphenocavernous and Infratemporal Trigeminal Neurinomas: Surgical Series of 15 Cases

Visot¹,

Derome²,

Leon³

1992

Skull Base

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“…They account for 0.07% to 0.36% of all intracranial tumors and 0.8% to 8% of all intracranial schwannomas [10] [14] [17] [19]- [25]. Interestingly, about 30% of trigeminal neurinomas are totally or predominantly confined to any portion of the trigeminal nerve namely cisternal, gasserian or the postganglionic section made of any of the three peripheral divisions of the nerve (ophthalmic, maxillary and mandibular) [2]- [15].…”

Section: Discussionmentioning

confidence: 99%

“…Trigeminal neurinomas can however, if small, arise from any portion of the trigeminal nerve namely cisternal, gasserian or the postganglionic section made of any of the three peripheral divisions of the nerve (ophthalmic, maxillary and mandibular). These tumors account for 0.07% to 0.36% of all intracranial tumors, around a third of all tumors of Meckel's cave and 0.8% to 8% of all intracranial schwannomas [6] [10] [13] [14] [15] [17] [18] [19]. As with other schwannomas, there could be an association with Neurofibromatosis type 2.…”

Section: Introductionmentioning

confidence: 99%

Voluminous Cystic Trigeminal Schwannoma: Case Report and Literature Review

Kakouc¹,

Mbende²,

Kouitcheu³

et al. 2017

OJMN

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Voluminous trigeminal schwannomas are rare, predominantly benign growth encapsulated tumors composed of Schwann cells with controversial surgical treatment. They account for 20% to 40% of all trigeminal schwannomas and share the same imaging findings of neurinomas elsewhere. Surgery remains the treatment of choice for most lesions as long as complete excision is feasible. A 35-year-old house wife complained of a 3-month history of progressive right visual field impairment associated with headaches. Neurological examination revealed a complete cavernous sinus syndrome. CT scanning showed a voluminous cystic mass of the right parasellar compartment extending to the optic nerve and the orbit. A concomitant MRI scan revealed more exquisite anatomical details of the lesion. The patient benefitted from a subsequent CT-angiography (not included) which excluded any vascular abnormalities associated with the tumor. Surgical excision of the tumor was warranted and the patient underwent surgery a few days after admission. A pterional extradural-intradural approach combined with incision of the lateral wall of the parasellar compartment via a standard frontotemporal craniotomy was performed and pathological examination was in favor of a cystic trigeminal schwannoma. Post-operative MRI showed a complete excision of the tumor. A 2-year follow-up yielded persistent right monocular blindness. Given this typical appearance of this lesion indicative of both cisternal and parasellar compartment extension, as well as the level of controversy surrounding surgical treatment of these particular tumors; we sought to report this rare case of a voluminous cystic trigeminal schwannoma and share our humble surgical experience of dealing with these lesions. The patient was informed that non-identifying information from the case would be submitted for publication, and she provided consent.

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Tumours of the fifth cranial nerve

Cited by 73 publications

References 22 publications

Primary melanoma of Meckel's cave: case report

Primary melanoma of Meckel's cave: case report

Sphenocavernous and Infratemporal Trigeminal Neurinomas: Surgical Series of 15 Cases

Voluminous Cystic Trigeminal Schwannoma: Case Report and Literature Review

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