Tumours of the Skin Appendages

MacKie, Rona M.; Calonje, Eduardo

doi:10.1002/9780470750520.ch37

Cited by 35 publications

(78 citation statements)

References 399 publications

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“…2 Importance of diagnosing ATs lies in the fact that in some instances the presence of ATs may lead to the recognition of a genetic syndrome, like Muir-Torre syndrome associated with sebaceous tumors, Cowden's syndrome with trichilemmomas etc. 1 In this study tumor did not contain element of two or more appendage in varying degrees of maturation. It is postulated that ATs are derived from cells that have the ability to differentiate toward any of the appendages.…”

Section: Discussionmentioning

confidence: 49%

“…The skin appendageal tumours (ATs) encompass a wide variety of tumours clinically presenting as papules and nodules and with histologically distinct features. 1 Majority of these tumors are benign. 3 They are basically classified into four groups: tumours with differentiation towards hair follicles, sebaceous glands, eccrine or apocrine glands.…”

Section: Introductionmentioning

confidence: 99%

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Clinico-pathological study of skin appendageal tumours from northern India

Jain¹,

Jain²,

Singh

et al. 2016

Int J Res Med Sci

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Section: Discussionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Clinico-pathological study of skin appendageal tumours from northern India

Jain¹,

Jain²,

Singh

et al. 2016

Int J Res Med Sci

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“…Subsequently, tumors metastasize to regional LNs and distant organs, leading to a poor outcome. 32 Although these clinical features indicate that EMPD progression is associated with tumor lymphangiogenesis and angiogenesis, the occurrence and the pathogenetic role of vascular activation in EMPD have not been studied. Moreover, little is understood about the mechanisms through which Paget cells acquire the invasive phenotype that spreads to LNs and beyond.…”

mentioning

confidence: 99%

Nodal Lymphangiogenesis and Metastasis

Hirakawa

Detmar

Kerjaschki

et al. 2009

The American Journal of Pathology

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Nodal lymphangiogenesis promotes distant lymph node (LN) metastasis in experimental cancer models. However, the role of nodal lymphangiogenesis in distant metastasis and in the overall survival of cancer patients remains unknown. Therefore, we investigated mechanisms that might facilitate regional and distant LN metastasis in extramammary Paget's disease (EMPD). We retrospectively analyzed the impact of tumor-induced lymphatic vessel activation on the survival of 116 patients, the largest cohort with EMPD studied to date. Nodal lymphangiogenesis was significantly increased in metastatic, compared with tumor-free, LNs (P ‫؍‬ 0.022). Increased lymphatic invasion within regional LNs was significantly associated with distant metastasis in LN (P ‫؍‬ 0.047) and organs (P ‫؍‬ 0.003). Thus, invasion within regional LNs is a powerful indicator of systemic tumor spread and reduced patient survival in EMPD (P ‫؍‬ 0.0004). Lymphatic vessels associated with tumors expressed stromal cell-derived factor-1 (SDF-1), whereas CXCR4 was expressed on invasive The metastatic spread of cancer cells from a primary site generally occurs in sentinel lymph nodes (LNs). Thus, the presence and extent of LN metastasis determines staging and prognosis in most human malignancies and often guides therapeutic decisions.1 Although surgical resection of primary tumors and their regional LN metastases can cure several types of cancer, distant LN and organ metastases represent a significant therapeutic concern due to the absence of effective antimetastatic therapies.

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“…40,41 Most SCCs complicating dystrophic EB show a propensity for metastatic spread and tumor progression, and their existence carries a grave prognosis. 40,41,45 Mutant p53 protein expression has been observed in a number of poorly differentiated SCCs, suggesting a correlation between p53 mutations and tumor behavior. 46 In contrast to dystrophic EB, only 2 cases of junctional EB complicated by malignant skin tumors have been reported to date.…”

Section: Commentmentioning

confidence: 99%