Tumours of the skin

Knottenbelt, Derek C.; Patterson-Kane, Janet C.; Snalune, Katie L.

doi:10.1016/b978-0-7020-4266-9.00031-3

Cited by 14 publications

(34 citation statements)

References 24 publications

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“…The pathological spectrum associated with the equine sarcoid is well recognised and, although there is histological controversy over some individual cases, the fibroblastic origin of the tumour is widely accepted (Knottenbelt et al . ).…”

Section: Introductionmentioning

confidence: 97%

“…Horses presented with superficial verrucose or occult sarcoid around the eye have been treated using 5% 5‐FU ointment (Efudix™) alone and a single 10‐day course of twice‐daily treatment (Knottenbelt et al . ). Likewise, treatment with a retinoid (0.1% tazarotene gel [Zorac™]) resulted in high recurrence (60%) and variable outcomes (Knottenbelt et al .…”

Section: Introductionmentioning

confidence: 97%

“…Likewise, treatment with a retinoid (0.1% tazarotene gel [Zorac™]) resulted in high recurrence (60%) and variable outcomes (Knottenbelt et al . ).…”

Section: Introductionmentioning

confidence: 97%

“…It is conventionally categorised into six different types according to the clinical features (Knottenbelt 2005) and pathological characteristics (Martens et al 2000(Martens et al , 2001. The pathological spectrum associated with the equine sarcoid is well recognised and, although there is histological controversy over some individual cases, the fibroblastic origin of the tumour is widely accepted (Knottenbelt et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Repeated intralesional infiltration with slow release cisplatin (Theon et al 1993) has also shown good results but requires considerable logistical input. Horses presented with superficial verrucose or occult sarcoid around the eye have been treated using 5% 5-FU ointment (Efudix TM ) 2 alone and a single 10-day course of twice-daily treatment (Knottenbelt et al 2015). Likewise, treatment with a retinoid (0.1% tazarotene gel [Zorac TM ] 3 ) resulted in high recurrence (60%) and variable outcomes (Knottenbelt et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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A pilot study on the use of ultra‐deformable liposomes containing bleomycin in the treatment of equine sarcoid

Knottenbelt

Watson

Hotchkiss

et al. 2018

Equine Veterinary Education

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Summary The efficacy of a novel topical liposome‐encapsulated preparation of bleomycin (Bleosome) was studied in 118 clinical cases of equine sarcoid and efficacy was compared with two other standard conventional treatments, tazarotene and 5‐fluorouracil (5‐FU) as well as with the Bleosome in combination with each of these two conventional treatments. Treatments were arbitrarily assigned. Fifty‐two of the 118 sarcoids (44%) were resolved after 12 months but there were significant differences between treatment groups with the combinations of either 5‐FU and bleomycin, or tazarotene and bleomycin resulting in significantly superior resolution of 77 and 78% of the lesions, respectively. The preliminary results suggest that bleomycin in a liposomal carrier may be a useful treatment modality for superficial, diffuse and verrucose sarcoids. The treatment process was simple, and outcomes were functionally and cosmetically excellent. Liposome‐encapsulated bleomycin is economic compared to radiation and other treatment options and can be applied effectively by the owner under guidance. Further studies with different administration protocols and higher concentrations of bleomycin are warranted.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

“…Likewise, treatment with a retinoid (0.1% tazarotene gel [Zorac™]) resulted in high recurrence (60%) and variable outcomes (Knottenbelt et al . ).…”

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A pilot study on the use of ultra‐deformable liposomes containing bleomycin in the treatment of equine sarcoid

Knottenbelt

Watson

Hotchkiss

et al. 2018

Equine Veterinary Education

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Complications of Skin Neoplasia

Archer

Wilmink²

2021

Complications in Equine Surgery

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Evisceration in a Thoroughbred gelding following application of a topical chemotherapy agent for the treatment of sarcoids

Baldwin

Mair

Busschers

2023

Equine Veterinary Education

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Summary This report describes the evisceration of the jejunum following acute dehiscence of the abdominal wall in an 18‐year‐old gelding, which had undergone treatment for suspected sarcoids on the ventral abdomen with a topical caustic/chemotherapy agent 6 weeks previously. The sarcoid lesions appeared to be responding appropriately to the topical therapy until the day of presentation. The jejunum was safely contained in an abdominal bandage and the horse underwent emergency referral before immediate anaesthesia and further assessment. The horse was euthanised at the owners' request following a guarded prognosis.

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Tumours of the skin

Cited by 14 publications

References 24 publications

A pilot study on the use of ultra‐deformable liposomes containing bleomycin in the treatment of equine sarcoid

A pilot study on the use of ultra‐deformable liposomes containing bleomycin in the treatment of equine sarcoid

Complications of Skin Neoplasia

Evisceration in a Thoroughbred gelding following application of a topical chemotherapy agent for the treatment of sarcoids

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