Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry

Case, R. A. M.; Hosker, Marjorie E; McDonald, Drever B.; Pearson, Joan

doi:10.1136/oem.50.5.389

Cited by 53 publications

(47 citation statements)

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“…For two groups (dyestuff and pigment manufacturing workers and textile dyers) most workers were likely to have had high exposure (SMR,51), while in the remainder (paper and paperboard manufacturing, textile finishing and linoleum and plastic floor covering manufacturing workers) most had low exposure (SMR,107). This suggests that little risk is associated with exposure to dyestuffs and is consistent with Case et al (1954) who demonstrated that carcinogenic risk among dyestuff workers resulted from exposure to aromatic amines during the manufacture of dyestuffs rather than from exposure to the dyestuffs themselves.…”

Section: Fishermensupporting

confidence: 73%

Occupation and bladder cancer: a death-certificate study

Dolin¹,

Cook-Mozaffari²

1992

Br J Cancer

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Summary Occupational statements on death certificates of 2,457 males aged 25-64 who died from bladder cancer in selected coastal and estaurine regions of England and Wales during [1965][1966][1967][1968][1969][1970][1971][1972][1973][1974][1975][1976][1977][1978][1979][1980] were studied.Excess mortality was found for deck and engine room crew of ships, railway workers, electrical and electronic workers, shoemakers and repairers, and tobacco workers. An excess of cases also occurred among food workers, particularly those employed in the bread and flour confectionary industry or involved in the extraction of animal and vegetable oils and fats. Use of a job-exposure matrix revealed elevated risk for occupations in which most workers were exposed to paints and pigments, benzene and cutting oils.Bladder cancer has been recognised as an occupational disease since the late part of the nineteenth century. The causal association with exposure to aromatic amines used in the chemical dyestuff and rubber industries has been well documented (IARC, 1990 (1-99,999; 100,000-249,999 and 250,000 + residents).Indirect age standardisation was used to calculate for each occupation and industry a mortality ratio standardised for age and degree of urbanisation (SMR). The SMR denominators were calculated by multiplying age-and urbanisationspecific mortality rates by the age-and urbanisation-specific population estimates for each occupation and industry.Ninety-five per cent confidence intervals were calculated using tables of confidence limits for the mean of a Poisson distribution (Pearson & Hartly, 1976).Assessment of risk associated with exposure to specific chemical agents was undertaken using a job-exposure matrix developed by Pannett and colleagues (Pannett et al., 1985). Occupations were identified in which a high proportion of workers in 1950 were likely to have been exposed to a specific chemical agent. The observed and expected number of deaths for the selected occupations were summed and an SMR calculated.

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Section: Fishermensupporting

confidence: 73%

Occupation and bladder cancer: a death-certificate study

Dolin¹,

Cook-Mozaffari²

1992

Br J Cancer

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“…As TCC became the more dominant histopathological type, the age at diagnosis increased possibly due to the long induction period associated with cigarette smoking and exposure to chemical carcinogens [36][37][38]. Studies from Western countries demonstrate the mean age at first bladder cancer diagnosis to occur between the sixth and seventh decades of life [6,7,39].…”

Section: Discussionmentioning

confidence: 99%

The changing patterns of bladder cancer in Egypt over the past 26 years

Felix

Soliman

Khaled

et al. 2008

Cancer Causes Control

141

110

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Objective-To evaluate temporal changes in histopathological types of bladder cancer and to assess associated changes in demographic, epidemiologic, and lifestyle risk factors.Methods-We abstracted data from all available medical records from the National Cancer Institute of Cairo University (NCI-Cairo). Six calendar years representing 5-year periods between 1980 and 2005 were evaluated. Information on demographics, schistosomal infection, clinical symptoms of bladder cancer, and tumor pathology was abstracted.Results-During this 26-year period, important changes in the frequency of histopathological types of bladder cancer occurred. We found a statistically significant association between time period of diagnosis and histopathological type. Patients diagnosed in 2005 had a sixfold higher odds associated with transitional cell carcinoma compared to those patients diagnosed in 1980 (odds ratio (OR) 6.00 (95% CI 4.00-8.97)).Conclusions-These data strongly suggest that the histopathological profile of bladder cancer in Egypt has changed significantly over the past 26 years. Historically, squamous cell carcinoma was the predominant form of bladder cancer in Egypt; however transitional cell carcinoma has become the most frequent type. These results corroborate findings from a few small-scale hospital-based studies which conclude that the etiology of bladder cancer in Egypt has changed significantly over the past 26 years.

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“…Compounds possessing the benzidine structure show carcinogenic effects when administered in vivo (Bi et al, 1992;Case et al, 1954). In contrast to Congo red, BSB may be beneficial in scintigraphic studies of systemic amyloidosis in humans, because it has no benzidine structure and can be easily modified at the Br position of the BSB molecule (Zhuang et al, 2001a(Zhuang et al, , 2001b.…”

Section: Evaluation Of Bsb In Systemic Amyloidosismentioning

confidence: 99%

“…Apple green birefringence under polarized light after Congo red staining is the most reliable evidence of the presence of amyloid fibrils in biopsy and/or autopsy materials from patients with amyloidosis (Sipe and Cohen, 2000;Westermark et al, 1999), although Congo red-stained histochemical sections are not always easy to interpret. However, the Congo red stain cannot be used for in vivo studies because it has toxic effects in the human body (Bi et al, 1992;Case et al, 1954;Kennelly et al, 1984;Zenser et al, 1998). Chrysamine G, a Congo red derivative with a similar molecular structure used for the same purpose as Congo red, has the same limitations (Dezutter et al, 1999(Dezutter et al, , 2001aKlunk et al, 1995Klunk et al, , 1998.…”

mentioning

confidence: 99%

A Novel Tool for Detecting Amyloid Deposits in Systemic Amyloidosis In Vitro and In Vivo

Ando

Haraoka

Terazaki

et al. 2003

Laboratory Investigation

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SUMMARY:We synthesized (trans,trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB) and used this compound to detect amyloid fibrils in autopsy and biopsy samples from patients with localized amyloidosis, such as familial prion disease, and systemic amyloidosis, such as familial amyloidotic polyneuropathy, amyloid A (AA) amyloidosis, light chain (AL) amyloidosis, and dialysis-related amyloidosis. BSB showed reactions in all Congo red-positive and immunoreactive regions of the samples examined in the study, and some amyloid fibrils in the tissues could be detected more precisely with BSB than with the other methods. In the mouse model of AA amyloidosis, injected BSB reacted with amyloid in all regions in the serial sections in which Congo red staining was positive. A highly sensitive 27-MHz quartz crystal microbalance analysis revealed that BSB showed a significant affinity for amyloid fibrils purified from familial amyloidotic polyneuropathy and dialysis-related amyloidosis samples and suppressed formation of transthyretin amyloid in vitro. These results suggest that BSB may become a valuable tool for detection of amyloid deposits in amyloidosis and of the mechanism of amyloid formation. (Lab Invest 2003, 83:1751-1759. P rogress in molecular genetics and biochemical methodologies has led to the identification of various types of amyloidosis and their amyloidogenic precursor proteins (Benson, 1995;Ikeda et al, 2002;Saraiva, 2001;Tan and Pepys, 1994;Tan et al, 1995). Thus far, 24 different amyloidogenic proteins have been identified; however, the mechanism of amyloid formation has been elucidated in only several types of amyloidosis Benson et al, 1993;Benson and Uemichi, 1996;Pepys et al, 1993;Soutar et al, 1992;Westermark et al, 2002). One of the most important steps in the diagnosis of the specific type of amyloidosis is detection of amyloid deposits in tissues. It is not easy to predict the presence of these amyloid deposits on the basis of patients' clinical manifestations, that is, without histopathologic materials. Thus, amyloidosis is sometimes diagnosed after the death of the patients (Ishihara et al, 1989).In systemic amyloidosis, such as familial amyloidotic polyneuropathy (FAP), AA amyloidosis, AL amyloidosis, and dialysis-related amyloidosis (DRA), biopsy samples are often obtained from the gastrointestinal tract and abdominal fat to make the diagnosis (Guy and Jones, 2001;Kaplan et al, 1999;Masouye, 1997) because amyloid deposits are usually found in these tissues at the early stage of the disease. However, in certain cases it is sometimes difficult to make the diagnosis using only the biopsy samples, because the pattern of amyloid deposition in the body varies in each individual (Ishihara et al, 1989). In addition, biopsy for diagnostic purposes cannot usually be performed in patients with localized amyloidosis, such as in Alzheimer's disease and endocrine amyloidosis (Westermark and Westermark, 2000). Diagnosis at the early stage of amyloidosis might be possible if a tool were avai...

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Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry

Cited by 53 publications

References 0 publications

Occupation and bladder cancer: a death-certificate study

Occupation and bladder cancer: a death-certificate study

The changing patterns of bladder cancer in Egypt over the past 26 years

A Novel Tool for Detecting Amyloid Deposits in Systemic Amyloidosis In Vitro and In Vivo

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