Tunable and high tissue adhesive properties of injectable chitosan based hydrogels through polymer architecture modulation

Jung, Ha Young; Thi, Phuong Le; Hwangbo, Kyung-Hee; Парк, Ки Донг

doi:10.1016/j.carbpol.2021.117810

Cited by 38 publications

(23 citation statements)

References 49 publications

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“…Many features such as cytotoxicity, mechanical properties as well as healing efficiencies have to be considered while fabricating a scaffold/substrate for tissue regeneration. Various existing methodologies have been adapted for processing of chitosan-based nanocomposites into films, 34 fiber-meshes, 35 hydrogels, [36][37][38][39][40] and 3D printed constructs 41 to mimic the 3D environment of tissues. Processing into a freestanding thin film is the easiest choice and affordable route to evaluate the physico-mechanical properties and biocompatibility of the designed nanocomposites.…”

Section: Chitosan-based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

“…Beyond films, chitosan-based hydrogels are fascinating biomaterials, as they possess a high amount of water, which makes them well compatible with most of the native tissues. 7,38,40,54 Gels comprise up to 10% solidphase in a total volume of the gel (the rest is water or liquid phase). This 10% solid phase warrant the consistency of the gel.…”

Section: Chitosan-based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

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Chitosan‐based nanocomposites for medical applications

Murugesan

Scheibel

2021

Journal of Polymer Science

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Chitosan as a biobased polymer is gaining increasing attention due to its extraordinary physico-chemical characteristics and properties. While a primary use of chitosan has been in horticultural and agricultural applications for plant defense and to increase crop yield, recent research reports display various new utilizations in the field of advanced biomedical devices, targeted drug delivery, and as bioimaging sensors. Chitosan possesses multiple characteristics such as antimicrobial properties, stimuli-responsiveness, tunable mechanical strength, biocompatibility, biodegradability, and water-solubility. Further, chitosan can be processed into nanoparticles, nano-vehicles, nanocapsules, scaffolds, fiber meshes, and 3D printed scaffolds for a variety of applications. In recent times, nanoparticles incorporated in chitosan matrices have been identified to show superior biological activity, as cells tend to proliferate/differentiate faster when they interact with nanocomposites rather than bulk or micron size substrates/scaffolds. The present article intents to cover chitosan-based nanocomposites used for regenerative medicine, wound dressings, drug delivery, and biosensing applications.

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Section: Chitosan-based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Section: Chitosan-based Nanocomposite Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Chitosan‐based nanocomposites for medical applications

Murugesan

Scheibel

2021

Journal of Polymer Science

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“…Furthermore, the toughness of the hydrogels indicating their capacity to absorb mechanical energy, was measured by integrating the compressive stress-strain curve 12 (Fig 3c). The DCCA hydrogel showed a significantly higher toughness (13.3 ± 0.9 kJ/m 3 ) compared to Ch (6.5 ± 0.8 kJ/m 3 ) and Alg (3.2 ± 0.3 kJ/m 3 ) hydrogels.…”

Section: Self-healing and Compression Properties Of Hydrogelsmentioning

confidence: 99%

“…[7][8][9] However, in addition to low solubility, the poly-β-(1,4)-D-glucosamine structure endows the chitosan hydrogel with high rigidity and an unsatisfactory energy dissipation mechanism resulting in brittle hydrogels. [10][11][12] The introduction of reversible interactions as secondary crosslinks to chitosan hydrogels can resolve the limitation caused by the polysaccharides' rigidity. For example, Xu et al developed a series of chitosan/vanillin hydrogels originating from reversible Schiff base reactions between the aldehyde group of vanillin and the amino group of chitosan.…”

Section: Introductionmentioning

confidence: 99%

Synergistic complexation of phenol functionalized polymer induced in situ microfiber formation for 3D printing of marine-based hydrogels

et al. 2022

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“…153 Enzymatic crosslinking reaction resulted chitosan/PEG hydrogel through injection via HRP. 154 Functiona modification resulted chitosan-hydroxyphenyl propionic acid and PEG-tyramine (PT) followed by gel formation. Several biomedical applications like excellent hemostatic ability with tunable physicochemical and tissue adhesive properties were originated from this biocompatible injectable gel (Figure 7).…”

Section: Injectable Propertiesmentioning

confidence: 99%

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Mukherjee

2022

Preprint

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Hydrogels are three-dimensional, hydrophilic, polymeric frameworks, constructed through diverse physical or chemical crosslinks. Recent research focuses on their physiological stimuli sensitivity enhancing bioapplications. Biopolymers with responsiveness to local environment like temperature, pH etc. form the foundation in this regard, around which all major natural processes are circulated. Polysaccharides, being most the abundant biopolymers and essential constituent of our daily food like cereals and fruits, are readily available in nature. Hence, among numerous biomacromolecules, polysaccharides are extensively used to prepare hydrogel recently. However, incorporation of certain properties to these gels through derivatization can trigger stimuli responsiveness suitable for various applications especially in biomedical field inspired from the mother nature. For example, in situ cross-linking ability may deliver an intermediate platform between solid scaffolds and saline injections through reversible or irreversible sol-gel transition. Easy injectability provides patient’s relief through reducing recovery time and inflectional hazards. Self recovery of gel within body results automatic inflammation and damage recovery of tissues. This review provides a detail impression on the synthesis of natural polysaccharide derived hydrogel network with structural classification to bulk, supramolecular, micro and nano gel. Several properties important from biomedical point such as in situ, injectable, self healing nature of these hydrogels and various physical, chemical, or biochemical stimuli-responsive characteristics are discussed further. Lastly, their major bioapplications are highlighted.

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Tunable and high tissue adhesive properties of injectable chitosan based hydrogels through polymer architecture modulation

Cited by 38 publications

References 49 publications

Chitosan‐based nanocomposites for medical applications

Chitosan‐based nanocomposites for medical applications

Synergistic complexation of phenol functionalized polymer induced in situ microfiber formation for 3D printing of marine-based hydrogels

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

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