Tunable environmental sensitivity and degradability of nanogels based on derivatives of cystine and poly(ethylene glycols) of various length for biocompatible drug carrier

Maćkiewicz, Marcin; Romański, J.; Krug, Pamela; Mazur, Maciej; Stojek, Zbigniew; Karbarz, Marcin

doi:10.1016/j.eurpolymj.2019.06.031

Cited by 32 publications

(13 citation statements)

References 46 publications

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“…The preparation of nanogels is divided into chemical methods and physical approaches. Chemical methods involve the formation of covalent bonds and the most common technology is the heterogeneous free radical polymerization (Li Z. et al, 2019;Mackiewicz et al, 2019;Gurnani and Perrier, 2020). Compared with traditional free radical polymerization, controlled living polymerization could synthesize polymers with specific structures and properties (Gurnani and Perrier, 2020).…”

Section: General Synthetic Methodsmentioning

confidence: 99%

Design and Applications of Tumor Microenvironment-Responsive Nanogels as Drug Carriers

Gao

Kang

et al. 2021

Front. Bioeng. Biotechnol.

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In recent years, the exploration of tumor microenvironment has provided a new approach for tumor treatment. More and more researches are devoted to designing tumor microenvironment-responsive nanogels loaded with therapeutic drugs. Compared with other drug carriers, nanogel has shown great potential in improving the effect of chemotherapy, which is attributed to its stable size, superior hydrophilicity, excellent biocompatibility, and responsiveness to specific environment. This review primarily summarizes the common preparation techniques of nanogels (such as free radical polymerization, covalent cross-linking, and physical self-assembly) and loading ways of drug in nanogels (including physical encapsulation and chemical coupling) as well as the controlled drug release behaviors. Furthermore, the difficulties and prospects of nanogels as drug carriers are also briefly described.

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Section: General Synthetic Methodsmentioning

confidence: 99%

Design and Applications of Tumor Microenvironment-Responsive Nanogels as Drug Carriers

Gao

Kang

et al. 2021

Front. Bioeng. Biotechnol.

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“…cluding their hydrophilicity, biocompatibility, higher colloidal stability, degradability, adjustable size, three-dimensional structure and ease of production, nanogels are regarded as the next generation of drug delivery technologies [20,21]. Furthermore, they have particular benefits over different kinds of nanomaterials in the biomedical area owing to their capacity to respond quickly to environmental changes like temperature, ionic strength, light and pH [9,22].…”

Section: Biopolymer-based Microgels/nanogels As a Drug Delivery Systemmentioning

confidence: 99%

Biopolymer-Based Nanogel Approach in Drug Delivery: Basic Concept and Current Developments

Altuntaş¹,

Özkan²,

Güngör³

et al. 2023

Preprint

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Due to their increased surface area, extent of swelling and active substance loading capacity and flexibility, nanogels made from natural and synthetic polymers have gained significant interest in the scientific and industrial areas. Especially, customized design and implementation of non-toxic, biocompatible, and biodegradable micro/nano carriers makes their usage very feasible for a range of biomedical applications, including drug delivery, tissue engineering, and bioimaging. The design and application methodologies of nanogels have been outlined in this review. Additionally, the most recent advancements in nanogel biomedical applications have been discussed, with a particular emphasis on applications for the delivery of drugs and biomolecules.

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“…To address these challenges with the aim to achieve more disease-specific drug release (and thus drug targeting), significant focus has been placed on the use of stimuli-responsive microgels that can change their physical properties (and thus affinity for the drug) in response to endogenous changes inside the body indicative of a disease state (such as changes in temperature, pH, , reduction potential, or enzyme concentration) or exogenous stimuli, like light, that can induce release on demand at a targeted location in the body . Using this approach, the strong drug–microgel affinity that allows for high drug uptake can be switched to a weaker drug–microgel affinity to enable useful dosing of the drug at the targeted site of release.…”

Section: Strategies To Control Hydrophobic Drug Release From Microgelsmentioning

confidence: 99%

Microgels and Nanogels for the Delivery of Poorly Water-Soluble Drugs

et al. 2022

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While microgels and nanogels are most commonly used for the delivery of hydrophilic therapeutics, the water-swollen structure, size, deformability, colloidal stability, functionality, and physicochemical tunability of microgels can also offer benefits for addressing many of the barriers of conventional vehicles for the delivery of hydrophobic therapeutics. In this review, we describe approaches for designing microgels with the potential to load and subsequently deliver hydrophobic drugs by creating compartmentalized microgels (e.g., core−shell structures), introducing hydrophobic domains in microgels, leveraging host−guest interactions, and/or applying "smart" environmentally responsive materials with switchable hydrophobicity. In particular, the challenge of promoting hydrophobic drug loading without compromising the inherent advantages of microgels as delivery vehicles and ensuring practically relevant release kinetics from such structures is highlighted, with an eye toward the practical translation of such vehicles to the clinic.

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Tunable environmental sensitivity and degradability of nanogels based on derivatives of cystine and poly(ethylene glycols) of various length for biocompatible drug carrier

Cited by 32 publications

References 46 publications

Design and Applications of Tumor Microenvironment-Responsive Nanogels as Drug Carriers

Design and Applications of Tumor Microenvironment-Responsive Nanogels as Drug Carriers

Biopolymer-Based Nanogel Approach in Drug Delivery: Basic Concept and Current Developments

Microgels and Nanogels for the Delivery of Poorly Water-Soluble Drugs

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