Tunable fabrication of folic acid-Au@poly(acrylic acid)/mesoporous calcium phosphate Janus nanoparticles for CT imaging and active-targeted chemotherapy of cancer cells

Wang, Huiyuan; Li, Shengnan; Zhang, Lingyu; Chen, Xiangjun; Wang, Tingting; Zhang, Manjie; Li, Lü; Wang, Chungang

doi:10.1039/c7nr05382g

Cited by 43 publications

(31 citation statements)

References 28 publications

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“…The presence of PEG-SH is supposed to probably disrupt the counterion complexation between Au NRs and chitosan due to the competitive binding of PEG-SH to Au NRs, which is consistent with the previously reported work. [28] In addition, the attachment of PEG onto the surface of Au NRs may also change the stability and dispersibility of Au NRs to affect the final products. As a result, J-Au-CS, T-Au-CS, and R-Au-CS with two distinct domains of Au NRs and chitosan could be formed.…”

Section: Fabrication Of Chitosan/gold Nanoparticles With Controlled Mmentioning

confidence: 99%

“…Carrying discrete domains in one nanostructure, JNPs are supposed to present the possibility of selective surface functionalization to realize distinct properties for versatile cancer therapy. [13,[23][24][25] In contrast with diverse inorganic JNPs, [26] the organic part of organic/inorganic hybrid JNPs applied currently is mostly poly(acrylic acid) (PAA), [23,[27][28][29] while the surface functionalization of PAA was usually realized by coating with mesoporous silica, [23] calcium phosphate, [28] manganese oxide, [29] polydopamine, [30] or metal-organic frameworks. [24] In this regard, the potential of the rich groups of organic domains for modification is far from being realized.…”

Section: Introductionmentioning

confidence: 99%

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Controlled Synthesis and Surface Engineering of Janus Chitosan‐Gold Nanoparticles for Photoacoustic Imaging‐Guided Synergistic Gene/Photothermal Therapy

Dai

Xiu-ling

Liu

et al. 2021

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110

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stability, biodegradability, ease of functionalization, and compromised toxicity. [1,2] Notably, polysaccharide/inorganic nanohybrids are considered ideal candidates as multifunctional platforms to combine the virtues of polysaccharides and intriguing inorganic nanoparticles. [3] Favorable synergistic properties arising from their integration could also be anticipated. [4] Recently, a variety of polysaccharide/inorganic nanohybrids have been fabricated via a nonsolvent-aided counterion complexation method while the morphology was limited to symmetrical spheres. [5-8] It is still a great challenge to obtain a controlled synthesis of a series of polysaccharide/ inorganic nanohybrids with adjustable morphologies to integrate the advantages of both components. On the other hand, unsymmetrical nanoparticles, especially Janus nanoparticles (JNPs), have attracted widespread interest since the morphology of nanoparticles greatly influences their properties and interactions with biological systems. [4,9,10] Compared with symmetrical core-shell-structured hybrid nanoparticles, JNPs demonstrate improved magnetic, optical, and drug-loading properties with more exposed areas of the components to maintain their characteristics. [11-13] Moreover, Near-infrared (NIR) light-responsive JNPs are also found to realize enhanced photothermal effect and penetration in tumors through self-propulsion, which is driven by the temperature gradient across the Janus boundary. [14-16] In these examples, photothermal gold nanoparticles including gold shells and stars were usually employed as a component of JNPs to realize active motion under NIR irradiation. On the other hand, gold nanorods are intriguing due to their tunable optical properties with different aspect ratios, which could be utilized to optimize photothermal performance and selective release of DNA by laser irradiation at different wavelengths. [17,18] However, distinct gold nanorods responsive to specific wavelengths of NIR light are still not well exploited in the fabrication of JNPs with enhanced photothermal performance. Gene therapy is considered a promising therapeutic modality to complement the limited light penetration of photothermal The unsymmetrical morphology and unique properties of Janus nanoparticles (JNPs) provide superior performances for biomedical applications. In this work, a general and facile strategy is developed to construct a series of symmetrical and unsymmetrical chitosan/gold nanoparticles. Taking advantage of the active motion derived from Janus structure, selective surface functionalization of polysaccharide domain, and photothermal effect of gold nanorods, Janus chitosan/gold nanoparticles (J-Au-CS) are selected as a model system to construct Janus-structured chitosan/gold nanohybrids (J-ACP). Near-infrared (NIR)-responsive J-ACP composed of polycationic chitosan nanospheres and PEGylated gold nanorods hold great potential to realize photoacoustic (PA) imaging-guided complementary photothermal therapy (PTT)/gene therapy for breast cancer. The morphol...

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Section: Fabrication Of Chitosan/gold Nanoparticles With Controlled Mmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Controlled Synthesis and Surface Engineering of Janus Chitosan‐Gold Nanoparticles for Photoacoustic Imaging‐Guided Synergistic Gene/Photothermal Therapy

Dai

Xiu-ling

Liu

et al. 2021

Small

110

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Section: What Is a Self‐propelled Micro/nanomotor?mentioning

confidence: 99%

Self‐Propelled Micro/Nanomotors for Sensing and Environmental Remediation

Zarei

2018

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140

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Self-propelled micro/nanomotors have gained attention for successful application in cargo delivery, therapeutic treatments, sensing, and environmental remediation. Unique characteristics such as high speed, motion control, selectivity, and functionability promote the application of micro/nanomotors in analytical sciences. Here, the recent advancements and main challenges regarding the application of self-propelled micro/nanomotors in sensing and environmental remediation are discussed. The current state of micro/nanomotors is reviewed, emphasizing the period of the last five years, then their developments into the future applications for enhanced sensing and efficient purification of water resources are extrapolated.

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“…Several polymeric-inorganic composite Janus NPs for theranostics have been reported by the Li and Wang groups 100,103,104. Notably, they demonstrated a synthetic strategy for the fabrication of polydopamine/ mesoporous calcium phosphate (PDA@mCaP) hollow Janus NPs, which were further decorated with PEG for stability and ICG for photothermal activity on the PDA domain (Figure 16).…”

Section: Biomedical Applications Of Janus Particlesmentioning

confidence: 99%

<p>Janus particles: recent advances in the biomedical applications</p>

Zhai

Chiu

et al. 2019

IJN

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Janus particles, which are named after the two-faced Roman god Janus, have two distinct sides with different surface features, structures, and compositions. This asymmetric structure enables the combination of different or even incompatible physical, chemical, and mechanical properties within a single particle. Much effort has been focused on the preparation of Janus particles with high homogeneity, tunable size and shape, combined functionalities, and scalability. With their unique features, Janus particles have attracted attention in a wide range of applications such as in optics, catalysis, and biomedicine. As a biomedical device, Janus particles offer opportunities to incorporate therapeutics, imaging, or sensing modalities in independent compartments of a single particle in a spatially controlled manner. This may result in synergistic actions of combined therapies and multi-level targeting not possible in isotropic systems. In this review, we summarize the latest advances in employing Janus particles as therapeutic delivery carriers, in vivo imaging probes, and biosensors. Challenges and future opportunities for these particles will also be discussed.

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Tunable fabrication of folic acid-Au@poly(acrylic acid)/mesoporous calcium phosphate Janus nanoparticles for CT imaging and active-targeted chemotherapy of cancer cells

Cited by 43 publications

References 28 publications

Controlled Synthesis and Surface Engineering of Janus Chitosan‐Gold Nanoparticles for Photoacoustic Imaging‐Guided Synergistic Gene/Photothermal Therapy

Controlled Synthesis and Surface Engineering of Janus Chitosan‐Gold Nanoparticles for Photoacoustic Imaging‐Guided Synergistic Gene/Photothermal Therapy

Self‐Propelled Micro/Nanomotors for Sensing and Environmental Remediation

<p>Janus particles: recent advances in the biomedical applications</p>

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