Tunable Physical Properties of Ethylcellulose/Gelatin Composite Nanofibers by Electrospinning

Liu, Yuyu; Deng, Lingli; Zhang, Cen; Feng, Fengqin; Zhang, Hui

doi:10.1021/acs.jafc.7b06038

Cited by 66 publications

(27 citation statements)

References 43 publications

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“…Electrospinning PVA/gelatine blends was used to create scaffolds with modifi ed hydrophobicity and morphology [11]. Similar results were found in ethyl cellulose/ gelatine blends, which could be tailored between hydrophobic and hydrophilic properties, showing tuneable water stability [12]. Zein/gelatine blends were found to show high crystallinity, resulting in the preservation of a porous 3D structure gained by electrospinning, which was not possible in pure gelatine or pure zein nanofi bers [13].…”

Section: Izvlečekmentioning

confidence: 70%

Water Resistance and Morphology of Electrospun Gelatine Blended with Citric Acid and Coconut Oil

Banner¹,

Dautzenberg²,

Feldhans³

et al. 2018

TEK

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Bio-polymer gelatine can be found in a broad variety of applications, mostly in the food industry. Moreover, it is used in the encapsulation of active pharmaceutical ingredients. In electrospinning, it is used for drug release, but can also strongly infl uence the morphologies of nanofi ber mats when blended with other polymers. In a recent project, we studied the infl uence of adding citric acid and coconut oil to gelatine electrospinning solutions. While the former can be used to modify gelatine nanofi ber diameters and create diverse morphologies between the fi bres and sprayed droplets of diff erent shapes, the latter results in an electrospraying process and additionally increases water resistance, suggesting a possible use of the combination for tailored drug release.

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Section: Izvlečekmentioning

confidence: 70%

Water Resistance and Morphology of Electrospun Gelatine Blended with Citric Acid and Coconut Oil

Banner¹,

Dautzenberg²,

Feldhans³

et al. 2018

TEK

View full text Add to dashboard Cite

show abstract

“…Therefore, it plays an important part in cell attachment, growth, migration and differentiation, as well as the formation of new tissues [10,11,12]. Meanwhile, gelatin fibers have strong adsorption, good filtration, barriers, adhesion and hygroscopicity [13,14,15,16]. Therefore, the gelatin 3D nanostructures prepared by electrospinning can be widely used in the biomedical materials, which receives more and more attention.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Gelatin Fibers Surface Loaded ZnO Particles as a Potential Biodegradable Antibacterial Wound Dressing

Chen

Guo

et al. 2019

Nanomaterials

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Traditional wound dressings require frequent replacement, are prone to bacterial growth and cause a lot of environmental pollution. Therefore, biodegradable and antibacterial dressings are eagerly desired. In this paper, gelatin/ZnO fibers were first prepared by side-by-side electrospinning for potential wound dressing materials. The morphology, composition, cytotoxicity and antibacterial activity were characterized by using Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), particle size analyzer (DLS), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), thermogravimetry (TGA) and Incucyte™ Zoom system. The results show that ZnO particles are uniformly dispersed on the surface of gelatin fibers and have no cytotoxicity. In addition, the gelatin/ZnO fibers exhibit excellent antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) with a significant reduction of bacteria to more than 90%. Therefore, such a biodegradable, nontoxic and antibacterial fiber has excellent application prospects in wound dressing.

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“…The water contact angle of CA/Gel and CA/Gel/Beri nanofibers were 58.07 ± 2.35° and 56.93 ± 1°, respectively, which indicated that the fabricated dressings are hydrophilic and proper for absorbing exudates and maintaining the moisture of the wound bed. Liu et al 54 demonstrated that the incorporation of Gel could increase the surface wettability of cellulose acetate due to its hydrophilic nature.…”

Section: Fabricatedmentioning

confidence: 99%

Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies

Samadian

Zamiri

Ehterami

et al. 2020

Sci Rep

207

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Functional wound dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/ Gelatin (CA/Gel) electrospun mat loaded with berberine (Beri) as the DFU-specific wound dressing. The wound healing efficacy of the fabricated dressings was evaluated in streptozotocin-induced diabetic rats. The results demonstrated an average nanofiber diameter of 502 ± 150 nm, and the tensile strength, contact angle, porosity, water vapor permeability and water uptake ratio of CA/Gel nanofibers were around 2.83 ± 0.08 MPa, 58.07 ± 2.35°, 78.17 ± 1.04%, 11.23 ± 1.05 mg/cm 2 /hr, and 12.78 ± 0.32%, respectively, while these values for CA/Gel/Beri nanofibers were 2.69 ± 0.05 MPa, 56.93 ± 1°, 76.17 ± 0.76%, 10.17 ± 0.21 mg/cm 2 /hr, and 14.37 ± 0.42%, respectively. The antibacterial evaluations demonstrated that the dressings exhibited potent antibacterial activity. The collagen density of 88.8 ± 6.7% and the angiogenesis score of 19.8 ± 3.8 obtained in the animal studies indicate a proper wound healing. These findings implied that the incorporation of berberine did not compromise the physical properties of dressing, while improving the biological activities. In conclusion, our results indicated that the prepared mat is a proper wound dressing for DFU management and treatment. Diabetes mellitus is classified as a metabolic disease that has various complications such as chronic wounds, arterial damage, and neuropathy resulting from uncontrolled blood sugar. The wound healing process is a complex and multiphase process that is delayed in diabetic patients because of various complexities 1,2. In these patients, the angiogenesis and re-epithelialization are inadequate because of low interaction between growth factors and their target site. Severe inflammation is an additional deleterious factor resulting from neutrophil infiltration. Moreover, diabetic foot ulcer (DFU) is another complication that is the consequence of intense inflammation,

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Tunable Physical Properties of Ethylcellulose/Gelatin Composite Nanofibers by Electrospinning

Cited by 66 publications

References 43 publications

Water Resistance and Morphology of Electrospun Gelatine Blended with Citric Acid and Coconut Oil

Water Resistance and Morphology of Electrospun Gelatine Blended with Citric Acid and Coconut Oil

Electrospun Gelatin Fibers Surface Loaded ZnO Particles as a Potential Biodegradable Antibacterial Wound Dressing

Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies

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