Tunable Properties of Porous Silicon

Canham, Leigh

doi:10.1007/978-3-319-71381-6_19

Cited by 13 publications

(8 citation statements)

References 49 publications

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“…The pSi layers had an average pore size of 13.6±4.1 nm and depth of 5.9±0.01 μm as determined by scanning electron microscopy (SEM) (Figure a and b). pSi layers were thermally oxidized in air at 600 °C for 1 h to improve their stability in aqueous solutions . Following this, plasma deposition was utilized to produce the polymeric capping films on the surface of the porous layer.…”

Section: Resultsmentioning

confidence: 99%

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Vasani

Szili

Rajeev

et al. 2017

Chemistry An Asian Journal

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Chronic wounds are am ajor socio-economic problem. Bacterial infections in such wounds are am ajor contributor to lack of wound healing. An early indicator of wound infection is an increasei np Ho ft he wound fluid. Herein, we describe the development of ap H-responsive drug delivery device that can potentially be used for wound decontamination in situ and on-demand in response to an increaseint he pH of the wound environment. The devicei sb ased on ap orouss ilicon film that provides ar eservoir for encapsulation of an antibiotic within the pores. Loaded porous silicon is capped withd ual plasma polymer layers of poly(1,7-octadiene) and poly(acrylic acid), which provide ap H-responsive barrierf or on-demand releaseo ft he antibiotic. We demonstrate that release of the antibiotic is inhibited in aqueous buffer at pH 5, whereas the drug is released in as ustainable mannera tpH8.Importantly,the released drugwas bacteriostatic against the Pseudomonas aeruginosa woundp athogen. In the future,i ncorporation of the delivery device into wound dressings could potentially be utilized for non-invasive decontamination of wounds.

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Section: Resultsmentioning

confidence: 99%

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Vasani

Szili

Rajeev

et al. 2017

Chemistry An Asian Journal

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“…PSi is commonly obtained via electrochemical etching, a fabrication strategy that does not require expensive equipment, and allows a good reproducibility of the fabricated PSi substrates. This technique enables a fine control on the pore size and on the optical response of the material [ 25 , 26 ]. This tuning is generally not easily achievable in other porous materials, such as porous alumina [ 27 , 28 ] or porous titania [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Porous Silicon Optical Devices: Recent Advances in Biosensing Applications

Moretta

Stefano

Terracciano

et al. 2021

Sensors

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This review summarizes the leading advancements in porous silicon (PSi) optical-biosensors, achieved over the past five years. The cost-effective fabrication process, the high internal surface area, the tunable pore size, and the photonic properties made the PSi an appealing transducing substrate for biosensing purposes, with applications in different research fields. Different optical PSi biosensors are reviewed and classified into four classes, based on the different biorecognition elements immobilized on the surface of the transducing material. The PL signal modulation and the effective refractive index changes of the porous matrix are the main optical transduction mechanisms discussed herein. The approaches that are commonly employed to chemically stabilize and functionalize the PSi surface are described.

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“…For some time, porous silicon (pSi) has attracted great attention in applications relevant to diagnosis and therapy, owing in part to its biocompatibility and biodegradability in aqueous physiologically-relevant environments [1,2,3,4]. Such a response in vitro/in vivo of pSi is sensitively dictated by porous morphology, associated Si domain dimension and surface chemistry [4,5]. While demonstrating utility in applications as diverse as bioimaging [6], drug delivery [7], and nucleotide sensing [8], pSi in a mesoporous form also exhibits some detrimental properties, namely intricate dendritric morphologies, and requires corrosive reagents in its preparation and expensive starting material (wafer grade Si).…”

Section: Introductionmentioning

confidence: 99%

Silicon Nanotubes as Potential Therapeutic Platforms

Tian

González-Rodríguez

et al. 2019

Pharmaceutics

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Silicon nanotubes (SiNTs) with unique well-defined structural morphologies have been successfully fabricated and recognized as a novel architecture in the nanoscale Si family. While the typical dendritic microstructure of mesoporous silicon prepared anodically has been exploited previously for therapeutics and biosensing, our status of utilizing SiNTs in this regard is still in its infancy. In this review, we focus on the fundamental properties of such nanotubes relevant to therapeutic applications, beginning with a description of our ability to sensitively tune the structure of a given SiNT through synthetic control and the associated detailed in vitro dissolution behavior (reflecting biodegradability). Emphasis is also placed here on the range of functional moieties available to attach to the surface of SiNTs through a summary of current studies involving surface functionalization and strategies that facilitate conjugation with molecules of interest for multiple purposes, including cell labeling, nucleotide attachment, and scaffolding of therapeutic metallic nanoparticles. Experiments addressing our ability to load the interior of a given nanotube with species capable of providing magnetic field-assisted drug delivery are also briefly described. Given the range of diverse properties demonstrated to date, we believe the future to be quite promising for employing SiNTs as therapeutic platforms.

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Tunable Properties of Porous Silicon

Cited by 13 publications

References 49 publications

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Porous Silicon Optical Devices: Recent Advances in Biosensing Applications

Silicon Nanotubes as Potential Therapeutic Platforms

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