Tunable seat belt behavior in nanocomposite interfaces inspired from bacterial adhesion pili

Dansuk, Kerim; Keten, Sinan

doi:10.1039/c7sm02300f

Cited by 9 publications

(7 citation statements)

References 51 publications

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“…The model is built at the particle scale and its parameters stand for unknown processes at a molecular scale. While it is clear that the type IV pili play a key role in bacterial adhesion [29][30][31][32], their complex interactions with surfaces and with other bacteria deserve to be studied extensively with, for example, mutant of variable number of pili or surfaces of controlled structure. The description proposed here does not, however, rely upon explicit cell-substrate or cell-cell adhesion mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Clustering of bacteria with heterogeneous motility

2020

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We study the clustering of a model cyanobacterium Synechocystis into microcolonies. The bacteria are allowed to diffuse onto surfaces of different hardness, and interact with the others by aggregation and detachment. We find that soft surfaces give rise to more microcolonies than hard ones. This effect is related to the amount of heterogeneity of bacteria's dynamics as given by the proportion of motile cells. A kinetic model that emphasizes specific interactions between cells, complemented by extensive numerical simulations considering various amounts of motility, describes the experimental results adequately. The high proportion of motile cells enhances dispersion rather than aggregation.

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Section: Discussionmentioning

confidence: 99%

Clustering of bacteria with heterogeneous motility

2020

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“…Owing to its important role in establishing infection, FimH is an attractive target for the development of anti-adhesive drugs for treatment of infections including urinary tract infections [ 91 , 119 ]. The properties of this interesting bacterial adhesin have therefore also simulated using both Monte Carlo [ 120 ] as well as MD simulations [ 121 ]. The catch-bond mechanism of FimH was also recently investigated, and a three-state mechanism of FimH catch-bond formation was suggested based on crystal structure studies, kinetic analysis of ligand interactions and molecular dynamics simulations [ 122 ].…”

Section: Mechanisms Of Glycan-based Adhesion Of Bacteriamentioning

confidence: 99%

The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can Single-Molecule Techniques Advance Our Understanding?

et al. 2018

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Bacterial adhesion is currently the subject of increased interest from the research community, leading to fast progress in our understanding of this complex phenomenon. Resent research within this field has documented the important roles played by glycans for bacterial surface adhesion, either through interaction with lectins or with other glycans. In parallel with this increased interest for and understanding of bacterial adhesion, there has been a growth in the sophistication and use of sensitive force probes for single-molecule and single cell studies. In this review, we highlight how the sensitive force probes atomic force microscopy (AFM) and optical tweezers (OT) have contributed to clarifying the mechanisms underlying bacterial adhesion to glycosylated surfaces in general and mucosal surfaces in particular. We also describe research areas where these techniques have not yet been applied, but where their capabilities appear appropriate to advance our understanding.

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“…As reversible interactions that become stronger with applied force, catch bonds can provide resistance to large mechanical stresses while allowing reconfiguration under small stresses in material systems. In particular, catch bonds have been shown, theoretically and computationally, [12][13][14][15] to enhance the mechanical properties of nanoparticle networks in nanocomposites. Certain non-biological molecules have been synthesized to mimic catch bond behavior.…”

Section: Introductionmentioning

confidence: 99%

A Simple Mechanical Model for Synthetic Catch Bonds

Dansuk

Keten

2019

Matter

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Dansuk and Keten have demonstrated that a simple mechanical design based on a tweezer-like mechanism can exhibit catch bond characteristics under thermal excitations. By introducing a switch design with broader energy landscape than the ligand binding site landscape, they achieve force-dependent kinetics that prolongs ligand lifetime through formation of secondary interactions. This serial arrangement of a soft conformational switch with a stiff ligand interaction results in catch bonds. The force versus lifetime curves are tunable by changing these design parameters.

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Tunable seat belt behavior in nanocomposite interfaces inspired from bacterial adhesion pili

Abstract: Chaperone-Usher pilus with catch bond adhesin—a bacterial biopolymer with the ability to attach to biotic/abiotic surfaces—can act as a “molecular seat belt” that has tunable cohesive strength and rate-responsive behavior.

Cited by 9 publications

References 51 publications

Clustering of bacteria with heterogeneous motility

Clustering of bacteria with heterogeneous motility

The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can Single-Molecule Techniques Advance Our Understanding?

A Simple Mechanical Model for Synthetic Catch Bonds

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