Tunicate-mimetic antibacterial hydrogel based on metal ion crosslinking and chitosan functionalization for wound healing

Zhang, Manyue; Xu, Wenxin; Li, Xiaodan; Ling, Guixia; Zhang, Peng

doi:10.1016/j.ijbiomac.2023.125062

Cited by 14 publications

(6 citation statements)

References 59 publications

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“…Biocompatibility is the fundamental necessity for a material intended to be used in direct contact with skin tissue [ 34 ]. Cell viability represents the initial assessment to analyze cellular mitochondrial function upon interaction with new materials [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Bioactive Composite Cryogels Based on Poly (Vinyl Alcohol) and a Polymacrolactone as Tissue Engineering Scaffolds: In Vitro and In Vivo Studies

Crețu,

Dodi,

Gardikiotis

et al. 2023

Pharmaceutics

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In light of the increasing resistance of pathogenic microorganisms to the action of antibiotics, essential oils extracted from plants with therapeutic activity provide a significant alternative to obtaining dressings for the treatment of skin wounds. The encapsulation of essential oils in an amphiphilic gel network allows better dispersion and preservation of hydrophobic bioactive substances while promoting their prolonged release. In this study, we focused on the development of a poly (vinyl alcohol) (PVA)/poly (ethylene brassylate-co-squaric acid) (PEBSA) platform embedded with thymol (Thy), and α-tocopherol (α-Tcp) as a co-drug structure with prospective use for the treatment and healing of skin wounds. The new complex bioactive system was prepared through repeated freeze–thaw processes. The influence of the composition on surface topography, hydrophilic/hydrophobic character, and in vitro interaction with simulated body fluids was evidenced. BALB/3T3 fibroblast cell culture demonstrated the cryogel scaffolds’ cytocompatibility. Tests on Wistar rats confirmed their biocompatibility, integration with host tissue, and the absence of inflammatory processes. The bioactive compound significantly enhanced the healing process of full-thickness excision wounds in a rat model. Further investigations on in vivo infection models would assess the potential of the PVA/PEBSA platform with dual bioactive activity for clinical antimicrobial and wound healing therapy.

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Section: Resultsmentioning

confidence: 99%

Bioactive Composite Cryogels Based on Poly (Vinyl Alcohol) and a Polymacrolactone as Tissue Engineering Scaffolds: In Vitro and In Vivo Studies

Crețu,

Dodi,

Gardikiotis

et al. 2023

Pharmaceutics

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“…42–44 Hydrogel microneedles with good water absorption and air permeability as wound dressings can protect wounds from bacterial infections. 45,46 Dissolving microneedles can rapidly release drugs to treat wounds. 47 Importantly, microneedles can break the barrier of bacterial biofilms to elevate the efficacy of antibacterial therapy.…”

Section: Introductionmentioning

confidence: 99%

A multimodal therapy for infected diabetic wounds based on glucose-responsive nanocomposite-integrated microneedles

Zhou,

Li,

Gao

et al. 2024

J. Mater. Chem. B

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“…These hydrogels could be applied in a liquid form, adapt seamlessly to wound site, and solidify in situ, although they lacked critical antibacterial and anti-inflammatory functions . Addressing the need for antibacterial capability, the common strategies included drug loading, cross-linking with antibacterial polymer, metal ion incorporation, and photodynamic or photothermal methods. − An example of this approach was the multifunctional CMCS-brZnO hydrogel developed by Hu et al, which integrated the fusiform zinc oxide nanorods into the carboxymethyl chitosan, offering controlled gelation, rapid self-healing, excellent tissue adhesion, and strong antibacterial properties, yet still with considerations on its mechanical strength and potential influence on the cell viability . In the context of antioxidation, the field was exploring grafting or doping hydrogels with antioxidants like natural polyphenols, curcumin, and dopamine. − A notable advancement in this area was the development of a near-infrared light-responsive hydrogel reported by Xie et al, which was designed to integrate the indocyanine green-loaded polydopamine-mediated graphene oxide and amorphous calcium phosphate into poly(vinyl alcohol), achieving antibacterial activity and ROS scavenging properties, thereby mitigating cellular inflammation and oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Photo-Cross-Linkable Hydrogel with Lubricating, Antimicrobial, and Antioxidant Properties for Bacteria-Infected Wound Healing

Guo,

Wang,

Wang

et al. 2024

Chem. Mater.

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Wound healing is a prolonged physiological process involving a series of complicated biological responses influenced by various factors, such as bacterial infection and oxidative damage. Existing treatments, while effective, have certain limitations in terms of biocompatibility, responsiveness to the wound environment, and efficacy in promoting tissue regeneration. To address these shortcomings, bioinspired by hydration lubrication mechanism of articular cartilage, we successfully designed and developed an injectable in situ photo-cross-linkable hydrogel, which was synthesized via modifying aminated hyaluronic acid with a polymer obtained by free radical polymerization of o-nitrobenzyl alcohol derivative (NB) and 2-methoxyethyl phosphocholine (MPC). The hydrophilic hydration layer formed around the zwitterionic charges in MPC endowed the hydrogel with enhanced lubrication and antimicrobial effects, whereas the hydroxymethyl group in NB enabled the hydrogel to process ultraviolet light-induced cross-linking property. The hydrogel, doped with polydopamine nanoparticles, facilitated multifaceted wound healing by the mechanism of photothermally responsive antibacterial, anti-inflammation, and angiogenesis. Specifically, upon injection of the hydrogel precursor solution into the wound site and exposure to ultraviolet light, the hydrogel cross-linked and adhered closely to the skin tissues, achieving hemostasis and exudate absorption. Additionally, the hydrogel showed excellent reactive oxygen species scavenging property, reducing cellular oxidative stress and meanwhile promoting the bactericidal effect with near-infrared light irradiation. Furthermore, the hydrogel, with its networked porous structure, was conducive to cell adhesion and proliferation, remarkably enhancing the cellular activity and tissue regeneration. The wound-healing performances of the hydrogel were investigated in both in vitro and in vivo experiments, showcasing its potential for wound treatment applications, offering a promising improvement over the current methods by providing a photothermal responsive, biocompatible, and effective healing process.

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Tunicate-mimetic antibacterial hydrogel based on metal ion crosslinking and chitosan functionalization for wound healing

Cited by 14 publications

References 59 publications

Bioactive Composite Cryogels Based on Poly (Vinyl Alcohol) and a Polymacrolactone as Tissue Engineering Scaffolds: In Vitro and In Vivo Studies

Bioactive Composite Cryogels Based on Poly (Vinyl Alcohol) and a Polymacrolactone as Tissue Engineering Scaffolds: In Vitro and In Vivo Studies

A multimodal therapy for infected diabetic wounds based on glucose-responsive nanocomposite-integrated microneedles

Photo-Cross-Linkable Hydrogel with Lubricating, Antimicrobial, and Antioxidant Properties for Bacteria-Infected Wound Healing

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