Tuning Ice Nucleation with Supercharged Polypeptides

Yang, Huige; Ma, Chao; Li, Kaiyong; Li, Kai; Loznik, Mark; Teeuwen, Rosalie L. M.; Hest, Jan C. M. van; Zhou, Xin; Herrmann, Andreas; Wang, Jianjun

doi:10.1002/adma.201600496

Cited by 62 publications

(59 citation statements)

References 33 publications

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“…Recently, we established a novel family of highly ionic repetitive polypeptides, termed supercharged unstructured polypeptides (SUPs) with NCD values higher than that reported for ELPs. This was achieved by introducing charged AAs into the pentapeptide VPGXG (Table ) wherein X represents the position of the charged AA . With this motif as starting point, SUPs were programmed with half of the charges employing (GVGVPGVGXP) n as repeat unit.…”

Section: Engineering Unstructured Supercharged Polypeptidesmentioning

confidence: 99%

Section: Applications Of Supercharged Unstructured Polypeptides In Thmentioning

confidence: 99%

“…Concurrently, understanding of ice nucleation on differently charged surfaces remains elusive. Yang et al reported a method of tuning of ice nucleation through systematic control of both the surface charge and charge density (Figure d) via modifying solid surfaces with SUPs. The authors varied the nature of charge and showed that cationic SUPs facilitate ice nucleation, while anionic SUPs suppress the process.…”

Section: Applications Of Supercharged Unstructured Polypeptides In Thmentioning

confidence: 99%

“…All these features are far beyond what is possible with conventional polyelectrolyte polymers. Supercharging proteins and polypeptides thus provides materials with exciting properties such as hyper‐temperature resistance and the ability of overcoming biological barriers in vivo . Moreover, these highly charged structures allow the assembly of bioliquids, organelle‐like condensed matter architectures, artificial biological nanocontainers, and interfacial coatings among many others.…”

Section: Introductionmentioning

confidence: 99%

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Supercharged Proteins and Polypeptides

Malessa

Boersma

et al. 2020

Advanced Materials

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Electrostatic interactions play a vital role in nature. Biomacromolecules such as proteins are orchestrated by electrostatics, among other intermolecular forces, to assemble and organize biochemistry. Natural proteins with a high net charge exist in a folded state or are unstructured and can be an inspiration for scientists to artificially supercharge other protein entities. Recent findings show that supercharging proteins allows for control of their properties such as temperature resistance and catalytic activity. One elegant method to transfer the favorable properties of supercharged proteins to other proteins is the fabrication of fusions. Genetically engineered, supercharged unstructured polypeptides (SUPs) are just one promising fusion tool. SUPs can also be complexed with artificial entities to yield thermotropic and lyotropic liquid crystals and liquids. These architectures represent novel bulk materials that are sensitive to external stimuli. Interestingly, SUPs undergo fluid–fluid phase separation to form coacervates. These coacervates can even be directly generated in living cells or can be combined with dissipative fiber assemblies that induce life‐like features. Supercharged proteins and SUPs are developed into exciting classes of materials. Their synthesis, structures, and properties are summarized. Moreover, potential applications are highlighted and challenges are discussed.

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Section: Engineering Unstructured Supercharged Polypeptidesmentioning

confidence: 99%

Section: Applications Of Supercharged Unstructured Polypeptides In Thmentioning

confidence: 99%

Section: Applications Of Supercharged Unstructured Polypeptides In Thmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Supercharged Proteins and Polypeptides

Malessa

Boersma

et al. 2020

Advanced Materials

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“…[1][2] Traditional methods of ice removal, for instances by active heating or using antifreeze fluids were proven to be energy-intensive or can yield unsolvable environmental problems. In the recent years, many researches have been focusing on developing environmental friendly passive icephobic surfaces that can repel the incoming cold water droplets, [3][4][5][6] delay ice nucleation, [7][8][9] and reduce ice adhesion strength. [10][11][12][13][14][15][16][17] Since ice formation on the surface was proven to be inevitable under harsh environment, numbers of studies have been devoted to develop surfaces with low ice adhesion strength (<100 kPa).…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Mechanical Durability of Icephobic Surfaces by Introducing Autonomous Self-Healing Function

Zhuo

Håkonsen

et al. 2018

ACS Appl. Mater. Interfaces

114

110

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Ice accretion presents a severe risk for human safety. Although great efforts have been made for developing icephobic surfaces (the surface with an ice adhesion strength below 100 kPa), expanding the lifetime of state-of-the-art icephobic surfaces still remains a critical unsolved issue. Herein, a novel icephobic material is designed by integrating an interpenetrating polymer network (IPN) into an autonomous self-healing elastomer, which is applied in anti-icing for enhancing the mechanical durability. The molecular structure, surface morphology, mechanical properties, and durable icephobicity of the material were studied. The creep behaviors of the new icephobic material, which were absent in most relevant studies on self-healing materials, were also investigated in this work. Significantly, the material showed great potentials for anti-icing applications with an ultralow ice adhesion strength of 6.0 ± 0.9 kPa, outperforming many other icephobic surfaces. The material also exhibited an extraordinary durability, showing a very low long-term ice adhesion strength of ∼12.2 kPa after 50 icing/deicing cycles. Most importantly, the material was able to exhibit a self-healing property from mechanical damages in a sufficiently short time, which shed light on the longevity of icephobic surfaces in practical applications.

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